Equipment to diagnosis the corneal neovascularization through its image captured by mobile phone

• Grant number: 18/08344-4
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Start date: May 01, 2019
• End date: October 31, 2020
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Tais Hitomi Wakamatsu
• Grantee: Tais Hitomi Wakamatsu
• Company: Vision Serviços Médicos Ltda
• CNAE: Atividades de serviços de complementação diagnóstica e terapêutica ; Atividades de apoio à gestão de saúde ; Atividades de atenção à saúde humana não especificadas anteriormente
• City: São Paulo
• Associated researchers: José Alvaro Pereira Gomes ; Ugo Ibusuki
• Associated scholarship(s): 19/17932-0 - Equipment for cornea neovascularization diagnosis utilizing images from mobile phone, BP.TT

Abstract

This project considers several challenges in the study and monitoring of the treatment of corneal neovascularization (NV). The cornea is by nature avascular, and thus kept constantly in healthy condition so that it presents its total transparency. The cornea consists of an outer layer of non-keratinized stratified squamous epithelium, a collagen stroma with keratocytes and, surrounding the anterior chamber, a cuboid endothelium (Rodrigues, 2015) with approximately 1mm of thickness at the periphery and 0.5mm at the center. The cornea, in addition to acting as a protective barrier for intraocular tissues, functions essentially as a transmitting element and refraction of incident light as a camera lens. For efficient light transmission it is essential to maintain the transparency of the cornea, a process in which avascularity is a key factor. In abnormal conditions of inflamed ocular surfaces, the cornea presents a strong tendency to vascularization, which predisposes to its opacity and consequent low vision. Corneal neovascularization becomes a priority study because it consists of a disorder that affects 1% of the general population and can cause blindness in almost 12% of patients with the symptom (Dastjerdi et al., 2009). The use of contact lenses, whose popularity has been increasing in recent decades, has become one of the main causes of NV. Contact lenses stimulate neovascularization, either causing mechanical irritation of the limbic sulcus and epithelial erosion, or through the induction of hypoxia and hypercapnia, which leads to limbic inflammation and release of mediators of angiogenesis leading to NV. Corneal neovascularization can lead to an irreversible loss of visual acuity, which implies an early and aggressive therapeutic approach through topical eye drops that should be monitored by medical specialists periodically (Wakamatsu, 2014). For treatment options to be adequately evaluated, corneal images should be taken at periodic intervals and the vascularization monitored longitudinally. However, several problems enter into the analysis, since the images may be of variable quality. Factors that may lead to differences or deterioration in the images are: (i) differences in illumination, between examinations; (ii) inter- or intra-operator variability in image taking; (iii) lack of sharpness in corneal images; (iv) lack of knowledge about the frequency-absorbing characteristics of eye tissues. The objective of this project is to develop an imaging equipment for the neovascularized area of the cornea through the development of a more economically viable national technology to enable images with adequate clarity for a better clinical diagnosis through the automatic extraction and calculation of the vascular area. The proposal is to develop a handheld device coupled with smartphones, making it easier for poorer and underserved populations to access eye exams, as well as queuing in public hospitals in large centers, and reducing the cost of purchasing sophisticated equipment for this purpose. The image extracted by this device will be processed by an artificial intelligence software that will calculate the neovascularized area of the cornea, compare with exams previously performed by the same patient and generate a diagnosis in an automated way. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

WAKAMATSU, TAIS HITOMI; DOS SANTOS, MYRNA SERAPIAO; BARREIRO, TELMA PEREIRA; SANT'ANNA, ANA ESTELA BESTETI PIRES PONCE; MURTA, FABIOLA; DA COSTA, ALEXANDRE XAVIER; MARCULINO, LEONARDO GUEDES C.; DE ALCANTARA, RAFAEL JORGE ALVES; DE FARIAS, CHARLES COSTA; GOMES, JOSE ALVARO PEREIRA. Clinical Aspects of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis With Severe Ocular Complications in Brazil. FRONTIERS IN MEDICINE, v. 8, JUN 18 2021. (18/08344-4, 12/09816-0)