Co-regulatory studies onto mitochondrial ribosome biogenesis and cytochrome oxidase assembly

• Grant number: 19/05232-3
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• Start date: July 23, 2019
• End date: September 22, 2019
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Agreement: CONFAP ; Newton Fund, with FAPESP as a partner institution in Brazil ; UK Academies
• Principal Investigator: Mario Henrique de Barros
• Grantee: Mario Henrique de Barros
• Visiting researcher: Gavin Peter Mcstay
• Visiting researcher institution: Staffordshire University, England
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The assembly of the mitochondrial respiratory complexes depends on proteins encoded by two different genomes, an unique situation in human cells that arise our interest on regulatories mechanisms involved in the proper steichiometric assembly of the respiratory complexes. Here, we propose to study a possible regulatory interconnection between cytochrome c oxidase (COX) assembly and the mitoribosome. Interactions of COX assembly factors, such as Cox14p and Coa3p, with mitoribosome proteins (e.g. mL38) will be explored through pull down assays in different mutant variants of these genes. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARROS, MARIO H.; MCSTAY, GAVIN P.. Modular biogenesis of mitochondrial respiratory complexes. MITOCHONDRION, v. 50, p. 94-114, JAN 2020. (19/05232-3)