Melatonin and physical performance: from ergogenic to accelerated skeletal muscle repair after damage induced by physical exercise

• Grant number: 19/08148-3
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2019
• End date: October 31, 2021
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Wladimir Rafael Beck
• Grantee: Wladimir Rafael Beck
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• City of the host institution: São Carlos
• Associated researchers: Anabelle Silva Cornachione

Abstract

Melatonin is an ubiquitous and amphiphilic indoleamine mainly biosynthesized by pineal gland and with classical chronobiological bond, nevertheless, has anti-inflammatory and antioxidant properties, inhibits lipid peroxidation, it is relevant in tissue damage protection, modulates substrate/energy content as well as activity of mitochondrial electrons transport chain, showing to have a important role on the intermediary metabolism. Due these properties, many sports researchers are investigating the effects of melatonin on this field. Then, our aim will be conducted in two different stages. The first stage will be analyzing the role of intermediary metabolism in the ergogenic effect under melatonin administration. Although there is evidence of the ergogenic character of endogenous and exogenous melatonin for exhaustive long-term exercise, it is still unclear about the involved physiological mechanisms. In the second stage, will analyze the effect of melatonin exogenous on muscle repair after a single high-load exercise session. Thus, we hope that our results may contemplate investigations of clinical and scientific relevance and elucidate knowledges about the participation of melatonin in physiological mechanisms involving skeletal muscle tissue. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

INFANTE, NICK ALEXANDRE; FARIA, VINICIUS SILVA; CORNACHIONE, ANABELLE SILVA; BARROS MANCHADO-GOBATTO, FULVIA; ZAGATTO, ALESSANDRO MOURA; BECK, WLADIMIR RAFAEL. Melatonin decreases PAX7 and CK increment after exercise-induced skeletal muscle damage. SPORT SCIENCES FOR HEALTH, v. N/A, p. 11-pg., 2025-03-12. (19/08148-3)

MELGES PEJON, TACIANE MARIA; FARIA, VINICIUS SILVA; GOBATTO, CLAUDIO ALEXANDRE; MANCHADO-GOBATTO, FULVIA BARROS; MENEZES SCARIOT, PEDRO PAULO; CORNACHIONE, ANABELLE SILVA; BECK, WLADIMIR RAFAEL. Effect of 12-wk Training in Ovariectomised Rats on PGC-1 alpha, NRF-1 and Energy Substrates. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. N/A, p. 10-pg., 2022-02-18. (19/08148-3, 13/21621-3)

BECK, WLADIMIR RAFAEL; SCARIOT, PEDRO PAULO MENEZES; PAPOTI, MARCELO; PEJON, TACIANE MARIA MELGES; POLISEL, EMANUEL ELIAS CAMOLESE; MANCHADO-GOBATTO, FULVIA BARROS; GOBATTO, CLAUDIO ALEXANDRE. Living High-Training Low on Mice Bone Parameters Analyzed through Complex Network Approach. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. N/A, p. 9-pg., 2024-11-13. (19/05115-7, 17/10201-4, 15/00272-6, 21/03951-2, 19/20930-9, 15/01362-9, 19/08148-3)

MELGES PEJON, TACIANE MARIA; MENEZES SCARIOT, PEDRO PAULO; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO; GOBATTO, CLAUDIO ALEXANDRE; CORNACHIONE, ANABELLE SILVA; BECK, WLADIMIR RAFAEL. Effects of Moderate-Intensity Physical Training on Skeletal Muscle Substrate Transporters and Metabolic Parameters of Ovariectomized Rats. METABOLITES, v. 12, n. 5, p. 14-pg., 2022-05-01. (19/08148-3)

FARIA, VINICIUS SILVA; PEJON, TACIANE MARIA MELGES; GOBATTO, CLAUDIO ALEXANDRE; DE ARAUJO, GUSTAVO GOMES; CORNACHIONE, ANABELLE SILVA; BECK, WLADIMIR RAFAEL. Acute melatonin administration improves exercise tolerance and the metabolic recovery after exhaustive effort. SCIENTIFIC REPORTS, v. 11, n. 1, SEP 28 2021. (19/08148-3)

POLISEL, EMANUEL E. C.; BECK, WLADIMIR R.; SCARIOT, PEDRO P. M.; PEJON, TACIANE M. M.; GOBATTO, CLAUDIO A.; MANCHADO-GOBATTO, FULVIA B.. Effects of high-intensity interval training in more or less active mice on biomechanical, biophysical and biochemical bone parameters. SCIENTIFIC REPORTS, v. 11, n. 1, MAR 19 2021. (15/00272-6, 18/07099-6, 19/05115-7, 15/01362-9, 19/08148-3, 14/10336-9, 17/10201-4)

PEJON, TACIANE MARIA MELGES; DE PAIVA, FELIPE GRACIANO; INFANTE, NICK ALEXANDRE; CORNACHIONE, ANABELLE SILVA; MONTEIRO, DIANA AMARAL; BECK, WLADIMIR RAFAEL. Melatonin Attenuates Oxidative Stress After an Exercise-induced Skeletal Muscle Damage. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. N/A, p. 8-pg., 2025-09-10. (13/07104-6, 19/08148-3, 20/01750-7)

SCARIOT, PEDRO P. M.; GOBATTO, CLAUDIO A.; POLISEL, EMANUEL E. C.; GOMES, ANA E. C.; BECK, WLADIMIR R.; MANCHADO-GOBATTO, FULVIA B.. Early-life mice housed in standard stocking density reduce the spontaneous physical activity and increase visceral fat deposition before reaching adulthood. LABORATORY ANIMALS, v. N/A, p. 12-pg., 2022-01-21. (17/10201-4, 14/10336-9, 19/08148-3, 15/01362-9, 15/00272-6, 18/07099-6, 19/05115-7)

FARIA, VINICIUS SILVA; MANCHADO-GOBATTO, FULVIA BARROS; SCARIOT, PEDRO PAULO MENEZES; ZAGATTO, ALESSANDRO MOURA; BECK, WLADIMIR RAFAEL. Melatonin Potentiates Exercise-Induced Increases in Skeletal Muscle PGC-1 alpha and Optimizes Glycogen Replenishment. FRONTIERS IN PHYSIOLOGY, v. 13, p. 11-pg., 2022-04-26. (19/08148-3)