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Multi-User Equipment approved in grant 2017/18782-6: Microscope Leica DM4


Despite the large amount of commercially available materials for use in regenerative medicine, there is still a great demand for materials with more suitable properties. The proposal of this project is the development of new polymeric materials and the study of its main characteristics for use in regenerative medicine. The materials will be based specifically on the reactions of Diels Alder due to their high efficiency, speed and being free of reaction byproducts, besides the purpose of the development of new materials with properties suitable for use in physiological condition. The objectives of the proposal are: (i) the development of polymers based on starch and poly (aspartic acid) capable of cross-linking by Diels Alder reactions; and (ii) the development of amino acid-based furanic polymers. To the starch and poly (aspartic acid) furan groups will be introduced for further cross-linking with bismaleimide; the amino acids will be chemically modified (moiety of furan or maleimide grouping) to generate monomers capable of polymerization by Diels Alder reaction. The crosslinking of the polymers (starch and polyaspartic acid) and the polymerization of the monomers (modified amino acids) give originality to the project. The materials will be characterized in terms of their chemical structures, physicochemical properties, biocompatibility and bioreabsorption in vitro. (AU)

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