Sympathetic nervous sistem, hypertension and fitness in post menopausal women submited to hormon replacement therapy

• Grant number: 01/14989-7
• Support Opportunities: Research Projects - Thematic Grants
• Start date: August 01, 2003
• End date: August 31, 2008
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Angela Maggio da Fonseca
• Grantee: Angela Maggio da Fonseca
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Cláudia Lúcia de Moraes Forjaz ; Decio Mion Junior

Abstract

It is not known the effects of estrogen replacement exercise, the aim of this study is to investigate the isolated and the combined impact of physical exercise and estrogen replacement in 60 histerectomized post menopausal women, 45 to 60 years old. At the begging of the study, at the 6th month and at the 12th month they will be submitted to: clinical evaluation, cardio respiratory evaluation, quality of life questionaire SF36, 24h Ambulatory Blood Pressure Monitoring, and to 2 experimental sessions where the physiological effects to the action of insulin (euglicemic/hiperinsulinemic clamp) and the sympathetic nervous system responses to physical and mental stress will be measured. The volunteers of this randomized double-blind study will be allocated in to 2 groups: estrogen replacement therapy (estradiol valerate 1 mg/day) and placebo. Both groups will be randomly assigned to trained group (aerobic training, cicloergometer, 50 minuts, 3 x week) and sedentary group. The voluntaries of the sedentary group will also be submitted to an extra session at the 6th month to evaluate the acute effect of physical exercise on the physiological answer to infusion of insulin. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ONEDA, BRUNA; FORJAZ, CLAUDIA L. M.; BERNARDO, FERNANDA R.; ARAUJO, TATIANA G.; GUSMAO, JOSIANE L.; LABES, ELIANA; ABRAHAO, SANDRA B.; MION, JR., DECIO; FONSECA, ANGELA M.; TINUCCI, TAIS. Low-dose estrogen therapy does not change postexercise hypotension, sympathetic nerve activity reduction, and vasodilation in healthy postmenopausal women. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 295, n. 4, p. H1802-H1808, OCT 2008. (01/14989-7)

ONEDA, BRUNA; CARDOSO, CRIVALDO G., JR.; FORJAZ, CLAUDIA L. M.; ARAUJO, TATIANA G.; BERNARDO, FERNANDA R.; DE GUSMAO, JOSIANE LIMA; PINTO, LUIZ GUSTAVO; LABES, ELIANA; ABRAHAO, SANDRA B.; MION, DECIO, JR.; et al. Effects of estrogen therapy and aerobic training on sympathetic activity and hemodynamics in healthy postmenopausal women: a double-blind randomized trial. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, v. 21, n. 4, p. 7-pg., 2014-04-01. (01/14989-7)

CARDOSO, CRIVALDO GOMES, JR.; MEDINA, FABIO LEANDRO; PINTO, LUIZ GUSTAVO; ONEDA, BRUNA; RIANI COSTA, LUIZ AUGUSTO; LABES, ELIANA; ABRAHAO, SANDRA BALIERO; TINUCCI, TAIS; MION, DECIO, JR.; FONSECA, ANGELA MAGGIO; et al. Oral estrogen therapy may mitigate the effects of aerobic training on cardiorespiratory fitness in postmenopausal women: a double-blind, randomized clinical pilot study. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, v. 21, n. 4, p. 7-pg., 2014-04-01. (01/14989-7)

CARDOSO JR‚ C.G.; SAKAI‚ D.; PINTO‚ L.G.; LABES‚ E.; DE GUSMÃO‚ J.L.; ABRAHÃO‚ S.B.; TINUCCI‚ T.; MION JR‚ D.; FONSECA‚ A.M.; FORJAZ‚ C.L.M.. Neurovascular and hemodynamic responses to hyperinsulinemia in healthy postmenopausal women. MATURITAS, v. 58, n. 1, p. 50-58, 2007. (01/14989-7)

CARDOSO, JR., CRIVALDO GOMES; ROSAS, FABRICIO COLLARES; ONEDA, BRUNA; LABES, ELIANA; TINUCCI, TAIS; ABRAHAO, SANDRA BALIEIRO; DA FONSECA, ANGELA MAGGIO; MION, JR., DECIO; DE MORAES FORJAZ, CLAUDIA LUCIA. Aerobic training abolishes ambulatory blood pressure increase induced by estrogen therapy: A double blind randomized clinical trial. MATURITAS, v. 69, n. 2, p. 184-189, JUN 2011. (01/14989-7)