| Grant number: | 19/16116-4 |
| Support Opportunities: | Regular Research Grants |
| Start date: | May 01, 2020 |
| End date: | October 31, 2022 |
| Field of knowledge: | Biological Sciences - Immunology - Cellular Immunology |
| Principal Investigator: | Alessandro dos Santos Farias |
| Grantee: | Alessandro dos Santos Farias |
| Host Institution: | Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
| City of the host institution: | Campinas |
Abstract
Our group has been focusing in the essential conditions to the pathogenicity of encephalitogenic T CD4+ cells during the early stage of EAE. Our preliminary results indicate that STAT5/CIS pathway could play an important role after these cells reach the central nervous system. We believe that this pathway could be essential to the conversion of Th17 into IFN³-producing cells, which we have demonstrated to present a cytotoxic activity. In general, the conversion of these cells must be direct related to the reactivation promoted by local APCs in the CNS. In this context, our data indicated that this interaction is mediated by the release of XCL-1 by the CD4+ T lymphocytes, which will recruit XCR-1 APCs. Therefore, in the present proposal, it is our intention to investigate the role of local APCs (specially XCR-1+) and STAT5/CIS pathway to the pathogenic activity of T CD4+ cells infiltrated into the CNS during the very early clinical phase of EAE. (AU)
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