CMOS microdevice to enable new brain stimulation therapies

• Grant number: 19/05248-7
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2020
• End date: August 31, 2022
• Field of knowledge: Engineering - Electrical Engineering - Electrical, Magnetic and Electronic Measurements, Instrumentation
• Principal Investigator: João Paulo Pereira Do Carmo
• Grantee: João Paulo Pereira Do Carmo
• Host Institution: Escola de Engenharia de São Carlos (EESC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated researchers: Eduardo Colombari ; Erich Talamoni Fonoff ; João Navarro Soares Júnior ; Maximiliam Luppe

Abstract

The project aims the development of medical microdevices with modules of acquisition, of signal processing, of control and of neurostimulation for new therapies of deep brain stimulation (DBS), which will compose microsystems with heterogeneous integration. The modules will be developed in a advanced CMOS (Complementary Metal Oxide Semeconductor) technology (CMOS with chanel lenght less or equal than 65 nm from TSMC (Taiwan Semiconductor Manufacturing Companny)) and low voltage supply (smaller than 1.2 V) to minimize dissipation, while facilitating power supply, in order to not compromise future applications for implantation within the brain. In order to validate the concept, acquisition modules with at least 8 acquisition channels and neurostimulation modules with 8 stimulation channels will be developed. The specifications for acquisition module include a maximum input-refered noise of 4 uVRMS and analog-digital conversion of 10, minimum sampling frequency of 200 kHz (to have at least 25 kHz for each analog channel) and maximum power consumpsion and FOM (Figure of Merit) of 3 uW and 29 fJ/(conversion step), respectively. The specification for the stimulator module include the possibility to generate current pulses with an arbitrary shape in the range from -450 uA to +450 uA, with a resolution of 200 nA, with a tunable frequency of up at least 130 Hz and with a minimum pulse duration of 90 us. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NORDI, TIAGO MATHEUS; GOUNELLA, RODRIGO HENRIQUE; LUPPE, MAXIMILIAM; SOARES JUNIOR, JOAO NAVARRO; FONOFF, ERICH TALAMONI; COLOMBARI, EDUARDO; ROMERO, MURILO ARAUJO; PEREIRA DO CARMO, JOAO PAULO. Low-Noise Amplifier for Deep-Brain Stimulation (DBS). ELECTRONICS, v. 11, n. 6, p. 24-pg., 2022-03-01. (19/05248-7)

SOUZA, MATEUS I. O.; MOTA, ACHILES FONTANA DA; PEPINO, VINICIUS MARRARA; CARMO, JOAO PAULO; BORGES, BEN-HUR VIANA. Multi-Purpose Microwave Biosensor Based on Signal Encoding Technique and Microfluidics for Improved Sensitivity. IEEE SENSORS JOURNAL, v. 21, n. 4, p. 4571-4581, FEB 15 2021. (19/05248-7, 13/07276-1)

NORDI, TIAGO MATEUS; BARBOSA, V. M.; GOUNELLA, R. H.; ASAN, GODFRED; LUPPE, MAXIMILIAM; NAVARRO, JOAO; JUNIOR, SOARES; CARMO, J. P.; FONOFF, ERICH TALAMONI; COLOMBARI, EDUARDO; et al. Charge-Pump Circuit in 65nm CMOS for Neural Stimulation on Deep-Brain Stimulation. 2021 XXXVI CONFERENCE ON DESIGN OF CIRCUITS AND INTEGRATED SYSTEMS (DCIS21), v. N/A, p. 4-pg., 2021-01-01. (19/05248-7)

NORDI, TIAGO MATHEUS; GINJA, GABRIEL AUGUSTO; GOUNELLA, RODRIGO; FONOFF, ERICH TALANONI; COLOMBARI, EDUARDO; MOREIRA, MELKZEDEKUE M. ALCANTARA; AFONSO, JOSE A. A.; MONTEIRO, VITOR; AFONSO, JOAO L. L.; CARMO, JOAO PAULO. Wireless Device with Energy Management for Closed-Loop Deep Brain Stimulation (CLDBS). ELECTRONICS, v. 12, n. 14, p. 21-pg., 2023-07-01. (19/05248-7)

GINJA, GABRIEL AUGUSTO; DE CAMPOS DA COSTA, JOAO PAULO; GOUNELLA, RODRIGO HENRIQUE; EIREZ IZQUIERDO, JOSE ENRIQUE; CARMO, JOAO PAULO; FONSECA, FERNANDO JOSEPETTI; CAVALLARI, MARCO ROBERTO; ANDO, OSWALDO HIDEO; DE SOUZA, SAMARA SILVA. A Humidity Sensor Based on Bacterial Nanocellulose Membrane (BNC). IEEE SENSORS JOURNAL, v. 23, n. 4, p. 8-pg., 2023-02-15. (19/18656-6, 19/05248-7, 19/24354-2)