Pathophysiology of Obstructive Sleep Apnea applied to therapeutic improvement

• Grant number: 18/20612-4
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: October 01, 2020
• End date: September 30, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Pedro Rodrigues Genta
• Grantee: Pedro Rodrigues Genta
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant(s): 22/03564-1 - Understanding the causes of obstructive sleep apnoea (OSA) in co-morbid insomnia and obstructive sleep apnoea (COMISA) and assessing its impact on treatment management, AP.R
• Associated scholarship(s): 22/14295-1 - Characterization of expiratory flow limitation by de signals of the nasal pressure cannula, BP.IC; 20/16168-1 - Challenges for increasing the effectiveness of Obstructive Sleep Apnea treatment, BP.TT

Abstract

Obstructive sleep apnea (OSA) is highly prevalent in the adult population and associated with high morbidity. OSA treatment remains a challenge due to limitations imposed by tolerability, elevated costs and effectiveness. The present proposal encompasses studies that focus on the understanding of the pathophysiology of OSA in a practical way, each aiming a clinical and immediate application. Four studies are proposed that involve: 1) evaluation of expiratory pressure relief during CPAP treatment, 2) assessment of the mechanisms associated with weight gain during CPAP treatment, 3) comparison of pharyngeal endoscopy during natural sleep and during sleep induced with propofol and, 4) noninvasive evaluation of epiglottic collapse through the nasal pressure cannula signal. The common goal of the proposed studies is to improve OSA treatment efficacy and tolerance. The studies will help to further establish the investigation of OSA pathophysiology by our laboratory. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

XAVIER, JEANE LIMA DE ANDRADE; FERNANDES, MARIANA DELGADO; LORENZI-FILHO, GERALDO; GENTA, PEDRO R.. Clinical Decision-making for Continuous Positive Airway Pressure Mask Selection. SLEEP MEDICINE CLINICS, v. 17, n. 4, p. 8-pg., 2022-11-02. (18/20612-4)

RODOLFO AUGUSTO BACELAR DE ATHAYDE; LEONARDO LUIZ IGREJA COLONNA; FABIOLA SCHORR; ELOISA MARIA MELLO SANTIAGO GEBRIM; GERALDO LORENZI-FILHO; PEDRO RODRIGUES GENTA. O tamanho da língua é importante: revisitando a classificação de Mallampati em pacientes com apneia obstrutiva do sono. Jornal Brasileiro de Pneumologia, v. 49, n. 2, 2023-04-28. (18/20612-4)