Development of a low cost insulin infusion pump

• Grant number: 18/22094-0
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Start date: December 01, 2020
• End date: November 30, 2023
• Field of knowledge: Engineering - Electrical Engineering - Industrial Electronics, Electronic Systems and Controls
• Principal Investigator: Sebastião Vagner Arêdes
• Grantee: Sebastião Vagner Arêdes
• Company: Aredes Equipamentos Hospitalares Ltda
• CNAE: Atividades de serviços de complementação diagnóstica e terapêutica
• City: São José dos Campos
• Pesquisadores principais: Luiz Eduardo Galvão Martins ; Tatiana de Sousa da Cunha Uchiyama
• Associated researchers: Dulce Elena Casarini ; Jane Dullius ; Juliana Almada Colucci Barros ; Monica Andrade Lima Gabbay ; Sergio Atala Dib ; Tiago de Oliveira
• Associated scholarship(s): 21/14283-0 - Evaluation of the physical, mechanical characteristics and feasibility of using commercial insulin refills in a low-cost insulin infusion pump prototype, BP.IC; 21/07173-4 - Development of the Mechanical Design of the Low Cost Insulin Infusion Pump, BP.TT

Abstract

The worldwide prevalence of diabetes melito (DM) has exponentially increased in the last decades. According to the World Health Organization this phenomenon acquired epidemic characteristics in several countries. If DM is not properly treated it can lead to very high social and economic costs. DM is the third major cause of premature mortality and it represents one of the most costs to the public health systems. The current estimation is that more than 425 million people suffer with DM, with about 75% of the cases in development countries. In Brazil, data from the Vigilance of Risk Factors and Protection against Chronical Diseases by Phone Inquire (Vigitel) showed that the prevalence of DM in the population above 18 years increased from 5.5% to 8.9% (between 2006 and 2016). Brazil is the fourth country in the world with DM, reaching about 16 million people. About 20-25% of people with DM need treatment with several daily application of injectable insulin, especially children and adolescents. At the end of the 20th Century several advances have happened in the diabetes treatment, which improved the management of the disease and their complications. Among the advances, we can pointed out the development of the insulin infusion pump, which is used in USA since 1970, but in Brazil only in the last 15 years it has been prescribed with more frequency. Approximately 15% of DM1 carriers have absolute indication to use insulin infusion pump, and despite the benefits of such a treatment the numbers of patients that can afford it is still much reduced, especially in Brazil. The main limitation to use this treatment is the high cost of the equipment, since the insulin infusion pumps available in Brazilian market are imported and their cost are about R$ 15.000,00. Therefore, this cost is prohibitive for the most part of the people with indication of using it. The aim of this project is to develop and produce an insulin infusion pump of low-cost, which will benefit the population that need such medical device, but can't afford its acquisition. The development of this project will place Brazil among the countries with technological skills to produce an insulin infusion pump of low-cost, aiming to supply the Brazilian market, with possibilities to expand for Latin-American, African and Asian markets. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARTINAZZO, ALDO; GALVAO MARTINS, LUIZ EDUARDO; AREDES, SEBASTIAO VAGNER; CUNHA, TATIANA SOUSA; ALMEIDA, JR; GONZALEZ, AR; SHEN, L; KANE, B; TRAINA, A; SODA, P; et al. Risk Management of a Low-cost Insulin Infusion Pump: A Case Study with a Brazilian Company. 2021 IEEE 34TH INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS (CBMS), v. N/A, p. 6-pg., 2021-01-01. (18/22094-0)

TENORIO, FERNANDA SILVA; MARTINS, LUIZ EDUARDO GALVAO; DA SILVA, GLORIA STHEFANY PEREIRA; MARTINS, CAMILA BERTINI; NEVES, ANA LUCIA DOMINGUES; CUNHA, TATIANA SOUSA. The Relationship Between Different Bench Test Methodologies and Accuracy of Insulin Infusion Pumps: A Systematic Literature Review. ANNALS OF BIOMEDICAL ENGINEERING, v. 50, n. 10, p. 16-pg., 2022-08-11. (18/22094-0)