Interstitial lung diseases (ILD): morphologic, functional and tomographic correlations using histochemistry, immunohistochemistry and morphometric techniques

• Grant number: 00/14336-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: April 01, 2001
• End date: September 30, 2007
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Vera Luiza Capelozzi
• Grantee: Vera Luiza Capelozzi
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant(s): 07/54022-4 - Immune phenotyping of inflammatory cells in bronchiolar interstitium of idiopathic interstitial pneumonias: preliminary study., AR.EXT
• Associated scholarship(s): 05/50836-1 - Organizing pneumonia: study of inflammation, angiogenesis and apoptosis in idiopathic and secondary forms, BP.IC

Abstract

Interstitial lung diseases (ILD) comprise a variety of clinicopathological entities, which share many features, but are sufficiently different from one another to be designated as separate disease entities. As a group they can be distinguished from other forms of diffuse parenchymal lung disease by clinical methods including history, physical examination, laboratory studies, chest radiology and pathology. Other members of diffuse interstitial lung diseases are occupational and environmental lung diseases, and parenchymal lung diseases associated with collagen vascular disease and a small number of other diseases of unknown etiology but with distinctive histopathology, like sarcoidosis and lymphangioleiomyomatosis. The purpose of this project is to investigate: 1) the role of histopathological markers to distinguishing the ILD's from other forms of diffuse parenchymallung disease; 2) the role of complementary techniques as the histochemistry and immunohistochemistry to improve the differential diagnosis and the etiopathogenesis among the ILD; 3) the correlation between clinical, pathological and radiological markers to establish degree of activity and prognosis of the ILD; 4) the role of the extracellular matrix remodelling in the comprehension of the pathogenetic mechanisms in the ILD. (AU)

Scientific publications

(14)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE PAIVA, LUIZ A. S.; PARRA, EDWIN R.; DA ROSA, DANIELI C.; FARHAT, CECILIA; DELMONTE, CARLOS; CAPELOZZI, VERA L.. Autopsy-Proven Determinants of Immediate Fire Death in Lungs. AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY, v. 29, n. 4, p. 323-329, DEC 2008. (00/14336-0)

PARRA‚ E.R.; DAVID‚ Y.R.; COSTA‚ L.R.S.; AB’SABER‚ A.; SOUSA‚ R.; KAIRALLA‚ R.A.; CARVALHO‚ C.R.R.; FILHO‚ M.T.; CAPELOZZI‚ V.L.. Heterogeneous remodeling of lung vessels in idiopathic pulmonary fibrosis. Lung, v. 183, n. 4, p. 291-300, 2005. (00/14336-0)

GARIPPO‚ AL; PARRA‚ ER; TEODORO‚ WR; VELOZA‚ AP; YOSHINARI‚ NH; CAPELOZZI‚ VL. Immune cell infiltration and broncovascular remodeling after nitric acid nasal instillation in a mouse bronchiolitis obliterans model. Lung, v. 184, n. 4, p. 229-238, 2006. (00/14336-0)

DE CARVALHO, E. F.; PARRA, E. R.; DE SOUZA, R.; SABER, A. M. A'B; MACHADO, J. DE CARVALHO; CAPELOZZI, V. L.. Arterial and interstitial remodelling processes in non-specific interstitial pneumonia: systemic sclerosis versus idiopathic. Histopathology, v. 53, n. 2, p. 195-204, 2008. (00/14336-0)

DE CARVALHO, ERIKA FRANCO; PARRA, EDWIN ROGER; DE SOUZA, ROMY; A'BSABER, ALEXANDRE MUXFELDT; CAPELOZZI, VERA LUIZA. Parenchymal and vascular interactions in the pathogenesis of nonspecific interstitial pneumonia in systemic sclerosis and idiopathic interstitial pneumonia. RESPIRATION, v. 76, n. 2, p. 146-153, 2008. (00/14336-0)

CAPELOZZI‚ M.A.; LEICK-MALDONADO‚ E.A.; PARRA‚ E.R.; MARTINS‚ M.A.; TIBÉRIO‚ I.F.L.C.; CAPELOZZI‚ V.L.. Morphological and functional determinants of fluoxetine (Prozac)-induced pulmonary disease in an experimental model. Respiratory Physiology & Neurobiology, v. 156, n. 2, p. 171-178, 2007. (00/14336-0)

APARECIDA DE CÁSSIA CARVALHO; EDWIN ROGER PARRA; MARIA CLÁUDIA ZERBINI; VENÂNCIO AVANCINI FERREIRA ALVES; VERA LUIZA CAPELOZZI; LEILA ANTONANGELO. A avaliação morfométrica de NB84, sinaptofisina e AgNOR é útil para o dignóstico histológico e prognóstico dos tumores neuroblásticos periféricos (pNTs). Clinics, v. 62, n. 6, p. 731-740, 2007-00-00. (00/14336-0)

L.M. MASSONI NETO; C.P. BIANCHI; A.M. AB'SABER; E.R. PARRA; T. TAKAGAKI; J.C. PEREIRA; F.A. SOARES; K. LEITE; V.L. CAPELOZZI. p53 immunostaining is correlated with reduced survival and is not correlated with gene mutations in resected pulmonary large cell carcinomas. Brazilian Journal of Medical and Biological Research, v. 40, n. 8, p. 1045-1053, 2007-06-04. (00/14336-0)

ALBERTO ANTONIO TERRABUIO JUNIOR; EDWIN ROGER PARRA; CECÍLIA FARHAT; VERA LUIZA CAPELOZZI. Causas de óbito por pneumonia intersticial secundária em autópsias pulmonares de pacientes imunocomprometidos. Clinics, v. 62, n. 1, p. 69-76, 2007-02-00. (00/14336-0)

CAMILO‚ R.; CAPELOZZI‚ V.L.; COELHO SIQUEIRA‚ S.A.; DEL CARLO BERNARDI‚ F.. Expression of p63‚ keratin 5/6‚ keratin 7‚ and surfactant-A in non-small cell lung carcinomas. HUMAN PATHOLOGY, v. 37, n. 5, p. 542-546, 2006. (00/14336-0)

BAPTISTA‚ A.L.; PARRA‚ E.R.; FILHO‚ J.V.B.; KAIRALLA‚ R.A.; DE CARVALHO‚ C.R.R.; CAPELOZZI‚ V.L.. Structural features of epithelial remodeling in usual interstitial pneumonia histologic pattern. Lung, v. 184, n. 4, p. 239-244, 2006. (00/14336-0)

DELGADO‚ L.; PARRA‚ ER; CAPELOZZI‚ VL. Apoptosis and extracellular matrix remodelling in human silicosis. Histopathology, v. 49, n. 3, p. 283-289, 2006. (00/14336-0)

PARRA‚ E.R.; KAIRALLA‚ R.A.; RIBEIRO DE CARVALHO‚ C.R.; EHER‚ E.; CAPELOZZI‚ V.L.. Inflammatory cell phenotyping of the pulmonary interstitium in idiopathic interstitial pneumonia. RESPIRATION, v. 74, n. 2, p. 159-169, 2007. (00/14336-0)

FELÍCIO‚ C.H.C.; PARRA‚ E.R.; CAPELOZZI‚ V.L.. Idiopathic and collagen vascular disease nonspecific interstitial pneumonia: clinical significance of remodeling process. Lung, v. 185, n. 1, p. 39-46, 2007. (00/14336-0)