Annual resource application plan for supporting institutional research infrastructure (ICB-USP 2018-2019)

• Grant number: 21/00070-5
• Support Opportunities: Research Grants - Technical Reserve for Institutional Research Infrastructure
• Start date: May 01, 2021
• End date: April 30, 2022
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Carlos Pelleschi Taborda
• Grantee: Carlos Pelleschi Taborda
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo

Abstract

The Institute of Biomedical Sciences of the University of São Paulo has a mission for conducting basic, applied and clinical research in the health field, as well as in innovation and biotechnology. The consolidation of this mission is represented by the extensive scientific production of our community in conjunction with the training and continued training of personnel associated with research activity at all levels, from pre-scientific initiation to post-doctorate. Our Institution is responsible for a considerable portion of the intellectual / scientific production at the University of São Paulo, maintaining scientific collaboration and innovation agreements with public and private institutions, both national and international. The extension of our research activity and its dissemination requires continuous support to our facilities and the maintenance of common spaces and equipment. We work in collaboration, thereby sharing equipment, laboratory spaces and basic infrastructure, which ensures frank interaction between researchers and rationalization in the use of available resources. Therefore, this proposal intends to meet the needs of our Unit, considering the multiuser spaces, the facilities of specific techniques used by the whole community, as well as the animal facilities, ensuring the basic operating conditions for continuity and expansion of the research conducted here. We propose the joint use of resources referring to the base years of 2018 and 2019, in order to make a large-scale project (the readjustment of the electrical infrastructure for research) viable, without giving up smaller, but no less important initiatives. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE SOUZA, ANACLETO SILVA; DE SOUZA, ROBSON FRANCISCO; GUZZO, CRISTIANE RODRIGUES. Cooperative and structural relationships of the trimeric Spike with infectivity and antibody escape of the strains Delta (B.1.617.2) and Omicron (BA.2, BA.5, and BQ.1). Journal of Computer-Aided Molecular Design, v. 37, n. 12, p. 22-pg., 2023-10-04. (21/10577-0, 19/00195-2, 21/00070-5, 16/09047-8, 20/04680-0)

DE SOUZA, ANACLETO SILVA; DE FREITAS AMORIM, VITOR MARTINS; DE SOUZA, ROBSON FRANCISCO; GUZZO, CRISTIANE RODRIGUES. Molecular dynamics simulations of the spike trimeric ectodomain of the SARS-CoV-2 Omicron variant: structural relationships with infectivity, evasion to immune system and transmissibility. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, v. N/A, p. 18-pg., 2022-10-29. (20/04680-0, 21/00070-5, 19/00195-2, 16/09047-8)

VISNARDI, ALINE BIAZOLA; RIBEIRO, RODOLFO ALVARENGA; DE SOUZA, ANACLETO SILVA; VINCES, TANIA GERALDINE CHURASACARI; LLONTOP, EDGAR E.; FERRARI, ANIELLE SALVIANO DE ALMEIDA; HENRIQUE, PEDRO ANTONIO FRANCA; VALDIVIESO, DANIELA; SANCHEZ-LIMACHE, DANIEL ENRIQUE; SILVA, GABRIELA ROBERTO; et al. Insertion of a Divergent GAF-like Domain Defines a Novel Family of YcgR Homologues That Bind c-di-GMP in Leptospirales. ACS OMEGA, v. 10, n. 4, p. 19-pg., 2025-01-21. (20/04680-0, 19/00195-2, 21/05262-0, 21/00070-5, 21/10577-0, 17/17303-7, 23/10432-7, 17/06394-1, 16/09047-8, 23/18211-0, 22/08730-7)

AMORIM, VITOR MARTINS DE FREITAS; SOARES, EDUARDO PEREIRA; FERRARI, ANIELLE SALVIANO DE ALMEIDA; MERIGHI, DAVI GABRIEL SALUSTIANO; DE SOUZA, ROBSON FRANCISCO; GUZZO, CRISTIANE RODRIGUES; DE SOUZA, ANACLETO SILVA. 3-Chymotrypsin-like Protease (3CLpro) of SARS-CoV-2: Validation as a Molecular Target, Proposal of a Novel Catalytic Mechanism, and Inhibitors in Preclinical and Clinical Trials. Viruses-Basel, v. 16, n. 6, p. 22-pg., 2024-06-01. (21/10577-0, 22/08730-7, 19/00195-2, 21/00070-5, 23/13894-1, 16/09047-8, 20/04680-0)