Prospecting the intestinal microbiota of horses with acute abdomen

• Grant number: 20/09633-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: May 01, 2021
• End date: April 30, 2026
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Carlos Augusto Araújo Valadão
• Grantee: Carlos Augusto Araújo Valadão
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
• Pesquisadores principais: Renata Gebara Sampaio Dória
• Associated researchers: Eliana Gertrudes de Macedo Lemos ; Márcio Carvalho da Costa ; Paulo Aléscio Canola ; Walter Heinz Feringer Júnior
• Associated scholarship(s): 21/06272-9 - Assessment of changes in the intestinal microbiota, through sequencing and bioinformatics platforms, of horses with naturally occurring acute abdomen, BP.PD

Abstract

Considering that the intestinal microbiota is profoundly modified in certain conditions, especially in gastrointestinal disorders, a better understanding of these changes during equine acute abdomen, with clinical or surgical evolution, may provide perspectives for adoption of new preventive and therapeutic measures. Several studies were carried out in order to determine the microbiome pattern in healthy horse feces. However, there are no studies that demonstrate changes in the microbiota caused by colic of different etiologies. Therefore, it is proposed to carry out a research project, divided into four experimental stages, in order to evaluate the effect of the overload of non-structural carbohydrates, a frequent type of clinical colic, on the intestinal microbiota of horses. Likewise, changes in the microbiota of horses with clinical colic of late resolution will be evaluated, such as compaction of the larger colon, concomitantly evaluating the bacterial translocation to peritoneal fluid, as well as horses with surgical colic, comparatively evaluating the fecal microbiota, intestinal segments and peritoneal fluid, in order to determine the occurrence of bacterial translocation. Also, the effect of antibiotic therapy on the equine microbiota, especially aminoglycosides, a drug routinely used in acute abdomen, will be evaluated. Thus, it will be possible to present a prospective study on the gastrointestinal microbiota of horses with naturally occurring and induced acute abdomen, evaluating the influence of antibiotic therapy, in order to provide information that can be used as prognostic indicators and that will serve as a basis for the development of adjuvant therapies in the recovery of horses with acute abdomen. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BUSTAMANTE, CAIO C.; DE PAULA, VANESSA B.; RABELO, ISABELA P.; FERNANDES, CAMILA C.; KISHI, LUCIANO T.; CANOLA, PAULO A.; LEMOS, ELIANA GERTRUDES DE M.; VALADAO, CARLOS AUGUSTO A.. Effects of Starch Overload and Cecal Buffering on Fecal Microbiota of Horses. ANIMALS, v. 12, n. 23, p. 14-pg., 2022-12-01. (20/09633-0, 15/24860-4)

BRITO, PEDRO HENRIQUE SALLES; FERREIRA, MARILIA ALVES; RUSCH, ELIDIANE; ARANTES, JULIA DE ASSIS; CARREGARO, ADRIANO BONFIM; VALADAO, CARLOS AUGUSTO ARAUJO; GHANTOUS, GIOVANA FUMES; DORIA, RENATA GEBARA SAMPAIO. Anesthesia for non-obstetric surgery during late term pregnancy in mares. PLoS One, v. 19, n. 11, p. 18-pg., 2024-11-22. (20/09633-0, 20/01387-0, 21/13378-8)

RABELO, ISABELA PEIXOTO; GUJANWSKI, CINTHYA DE ANDRADE; VIANA, INACIO SILVA; DE PAULA, VANESSA BARROCO; REIN, ARIADNE; RABELO, SARA PEIXOTO; VALADAEO, CARLOS AUGUSTO ARAUJO. Intranasal vs. intramuscular administration of azaperone, midazolam and ketamine in pigs. FRONTIERS IN VETERINARY SCIENCE, v. 11, p. 11-pg., 2024-09-25. (20/09633-0)

MARIANA DE OLIVEIRA ALMEIDA; DANIELA JUNQUEIRA DE QUEIROZ; RENATA GEBARA SAMPAIO DÓRIA; ADRIANA COELHO DE SOUZA; KETHERSON RODRIGUES SILVA; ANTONIO FERNANDO BARIANI JUNIOR. Carcinoma de plexo coroide em cavalo: relato de caso. Ciência Rural, v. 55, n. 4, 2024-11-29. (20/09633-0)