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Starch modification by green methods for elaboration via 3D printing of bone scaffolds activated by the presence of hydroxyapatite nanoparticles replaced by Sr2+

Abstract

Recent efforts on the field of Tissue Engineering to develop resorbable bone scaffolds that mimic the structure and function of natural bone have been reported. A good bone substitute material has to reach minimum requirements such as: mechanical properties similar to target tissue, in addition to stimulate biochemical reactions fundamentals to osteointegration and osteoconduction. In this sense, composites composed of organic matrices and biominerals that are capable of mimicking bones can reach these requirements. Starch is an interesting alternative for the production of biomaterials. In addition, starch was already used for 3D printing. However, native starches have processing difficulties, high swelling, highly hydrophilic character, low mechanical resistance and instability for long-term application. In order to overcome these obstacles, methods of modifying starch have been useful for improving its functionality. As an example, starches modified by ozonation and dry heating have shown improved printability. The production via 3D printing of bone scaffolds using this modified starch is innovative and should combine its already known biocompatibility and mechanical properties with the bioactivity of biominerals. Thus, the aim of this project is to modify starches by green methods (ozonation, dry heating and moist heating) and then to evaluate their application as bone scaffolds. It will be evaluated the formulations based on modified starch, in which hydroxyapatite nanoparticles will be replaced by strontium, since the presence of this cation has been associated with the process regulation of bone formation and resorption. The production of bone scaffolds via 3D printing by extrusion can lead to materials with improved properties and also customized structure, thus, a unique. The mechanical properties of scaffolds will be evaluated simultaneously with their surface properties, combined with osteoblast and osteoclast cultivation. The cultivation of osteogenic cells on the 3D matrix, very likely, will assist to predict their tissue regenerative properties in vivo. Finally, this project will correlate aspects such as different formulations and innovative processing (3D printing) to obtain bone scaffolds with bioactive properties. This project can expand the application of starch, in particular as personalized biomaterials with unique properties, adding value to the starch chain and mainly a noble use (human health). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NOGUEIRA, LUCAS FABRICIO BAHIA; MANIGLIA, BIANCA C.; BUCHET, RENE; MILLAN, JOSE LUIS; CIANCAGLINI, PIETRO; BOTTINI, MASSIMO; RAMOS, ANA PAULA. Three-dimensional cell-laden collagen scaffolds: From biochemistry to bone bioengineering. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, NOV 2021. Web of Science Citations: 0.
MANIGLIA, BIANCA CHIEREGATO; ARIAS LA FUENTE, CARLA IVONNE; SIQUEIRA, LARISSA DO VAL; TADINI, CARMEN CECILIA. Carbohydrate Nanomaterials Addition to Starch-Based Packaging: A Review about Fundamentals and Application. STARCH-STÄRKE, v. 73, n. 11-12, SI JUL 2021. Web of Science Citations: 0.

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