Starch modification by green methods for elaboration via 3D printing of bone scaffolds activated by the presence of hydroxyapatite nanoparticles replaced by Sr2+

• Grant number: 21/08359-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2021
• End date: July 31, 2022
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Bianca Chieregato Maniglia
• Grantee: Lucas Santos Silva
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 20/08727-0 - Starch modification by green methods for elaboration via 3D printing of bone scaffolds activated by the presence of hydroxyapatite nanoparticles replaced by Sr2+, AP.JP

Abstract

3D printing of bone scaffolds based on starch gels and hydroxyapatite nanoparticles has been reported in the literature. Synthetic hydroxyapatite, despite showing structural similarity with biological apatite, does not present its bioactivity, since biological apatite has trace elements that play a key role in the bone remodeling process. More specifically, hydroxyapatite nanoparticles substituted with Sr2+ ions have been associated with the regulation of bone formation and resorption processes. Thus, this project aims to evaluate the effect of the molar percentage of Sr2+ ions in hydroxyapatite nanoparticles on the bioactivity of bone scaffolds (based on starch gels) produced via 3D printing. The bioactive properties evaluated will be: in vitro bioactivity, cell viability, mineralization capacity, and evaluation of the release of Sr2+ ions. Finally, this study will make it possible to understand how strontium ions can cooperate with the bioactivity of custom bone scaffolds based on starch gels produced via 3D printing. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA, LUCAS SANTOS; DE MELO, MARYANNE TRAFANI; SPONCHIADO, PEDRO AUGUSTO INVERNIZZI; BARBOSA JUNIOR, FERNANDO; TAPIA-BLACIDO, DELIA RITA; CIANCAGLINI, PIETRO; RAMOS, ANA PAULA; MANIGLIA, BIANCA CHIEREGATO. Synthesis of composite corn starch/hydroxyapatite nanoparticle biomembranes and their effect on mineralization by osteoblasts. Journal of Applied Polymer Science, v. 140, n. 43, p. 14-pg., 2023-08-18. (19/08568-2, 21/08359-4, 20/08727-0, 19/25054-2, 21/05947-2)