Functionalization of D-glucal and analogs via carbonylative coupling reactions

• Grant number: 20/00295-4
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2021
• End date: March 31, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Helio Alexandre Stefani
• Grantee: Helio Alexandre Stefani
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The project has as its main focus the use of 2-iodo-D-glucal and analogs in transformations involving carbonylative coupling reactions. It is also intended, whenever possible, to evaluate the biological activity of the prepared compounds (antifungal, anticancer and anti-inflammatory activity). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PASCHOALIN, CAIO; TOLEDO, MONICA F. Z. J.; VERISSIMO, DAYANE; HORNINK, MILENE M.; PIMENTA, DANIEL C.; STEFANI, HELIO A.. Synthesis of Gluco-Alkynones via a Carbonylative Coupling Reaction Using 1-Iodoglucal. CHEMISTRYSELECT, v. 8, n. 35, p. 8-pg., 2023-09-20. (20/00295-4)

DE JESUS, DANIEL FELIPE FREITAS; DE FREITAS, ALINE LUIZA DUARTE; DE OLIVEIRA, ISADORA MARIA; DE ALMEIDA, LARISSA COSTA; BASTOS, RAFAEL WESLEY; SPADARI, CRISTINA DE CASTRO; MELO, ANALY SALES DE AZEVEDO; SANTOS, DANIEL DE ASSIS; COSTA-LOTUFO, LETICIA VERAS; REIS, FLAVIA C. G.; et al. Organoselenium Has a Potent Fungicidal Effect on Cryptococcus neoformans and Inhibits the Virulence Factors. Antimicrobial Agents and Chemotherapy, v. 67, n. 3, p. 16-pg., 2023-02-23. (16/04289-3, 17/15226-5, 21/01279-5, 18/12149-2, 20/00295-4, 15/17177-6)

DE JESUS, JESSICA C.; NOGUCHI, HENRIQUE K.; TOLEDO, MONICA F. Z. J.; BURROW, ROBERT A.; PIMENTA, DANIEL C.; STEFANI, HELIO A.. Synthesis of Glycal Amides from Amino Acid Esters by Carbonylative Coupling Reaction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v. 2022, n. 30, p. 7-pg., 2022-08-12. (20/00295-4)