Cardioprotection in Diabetes mediated by aerobic physical training and the role of brown adipose tissue

• Grant number: 20/15748-4
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2021
• End date: April 30, 2024
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Fabiana de Sant'Anna Evangelista
• Grantee: Fabiana de Sant'Anna Evangelista
• Host Institution: Escola de Artes, Ciências e Humanidades (EACH). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant(s): 24/23501-0 - American Physiology Summit, AR.EXT

Abstract

The development of cardiomyopathy in diabetics can lead to an unfavorable clinical outcome, and due to the high prevalence, the search for understanding the pathophysiology and forms of prevention and treatment are increasing in the literature. Key factors such as cardiomyocyte metabolic imbalance, lipotoxicity, fibrosis and cardiac hypertrophy mediate cardiac damage, and part of the mechanisms may be related to the remote action of adipose tissue. While the excess of white adipose tissue is associated with cardiovascular disease and comorbidities, brown adipose tissue (BAT) can improve cardiovascular health via increased substrate oxidation and endocrine action. One of the proteins secreted by BAT with the greatest cardioprotective property is the fibroblast growth factor 21 (FGF-21). Among the strategies to combat cardiometabolic diseases, aerobic physical training (APT) has been shown to be effective in inducing beneficial adaptations in energy metabolism, in the heart and in adipose tissue. In addition, it is known that APT increases the production of FGF-21, as well as its FGFR1 receptor and the ²-Klotho transmembrane protein. Knowing that maintaining BAT functionality is important for metabolic and cardiovascular health, investigating the relationship between BAT and diabetic cardioprotection through APT, as well as the participation of FGF21, can answer a knowledge gap that still exists in the literature. Thus, the present project aims to test the hypothesis that BAT participates in APT-induced cardioprotection in diabetic animals, and that this response is associated with increased levels of FGF21 and FGFR1/²-klotho. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

EVANGELISTA, FABIANA S.; FERREIRA, MARILIA M.; FORTUNATO-LIMA, VANESSA C.; CORREA, SAULO M.; VECCHIATTO, BRUNO; MARTUCCI, LUIZ F.; MULLER, CYNTHIA R.; AMERICO, ANNA LAURA V.. Metabolic Cooperation Between Adipose Tissue and Skeletal Muscle Mediates the Prevention of NAFLD Through Aerobic Physical Exercise. FASEB JOURNAL, v. 36, p. 1-pg., 2022-01-01. (16/23783-9, 20/15748-4, 16/20659-5)

VECCHIATTO, BRUNO; DE CASTRO, THIAGO LUCAS; MULLER, CYNTHIA R.; AZEVEDO-MARTINS, ANNA KARENINA; EVANGELISTA, FABIANA S.. Physical Exercise-Induced FGF-21 to Fight Obesity: An Update Review. OBESITIES, v. 2, n. 4, p. 8-pg., 2022-12-01. (20/12005-0, 20/15748-4)

EVANGELISTA, FABIANA; VECCHIATTO, BRUNO; CASTRO, THIAGO; MARTUCCI, LUIZ FELIPE; MULLER, CYNTHIA. Effects of physical exercise on glycemic metabolism, aerobic capacity and structure of brown adipose tissue in diabetic animals. PHYSIOLOGY, v. 38, p. 2-pg., 2023-05-01. (20/15748-4, 20/12005-0)