| Grant number: | 22/05495-7 |
| Support Opportunities: | Multi-user Equipment Program |
| Start date: | July 01, 2022 |
| End date: | June 30, 2029 |
| Field of knowledge: | Health Sciences - Dentistry - Dental Materials |
| Principal Investigator: | Estevam Augusto Bonfante |
| Grantee: | Estevam Augusto Bonfante |
| Host Institution: | Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil |
| City of the host institution: | Bauru |
| Associated research grant: | 21/06730-7 - Towards sustainable zirconia recycled from milling waste and boosted by glass infiltration for restorative use, and of the development of strong, graded, and aging resistant multilayered zirconia blocks, AP.JP2 |
Abstract
In JP-2 we propose the synthesis of aging resistant, strong and adhesive-friendly polycrystalline multilayered ceramics for monolithic use and to develop a zirconia recycling method to be boosted by glass infiltration in multilayered systems. Our efforts that culminated in prostheses framework developments of JP-1 are called GAP 1. In GAPS 2 and 3 proposed for JP-2, we aim to produce blocks of isolated pristine zirconia powders (3Y-TZP, 4Y-PSZ, and 5Y-PSZ) and their combinations as bilayered (3Y-TZP +4Y-PSZ, 3Y-TZP+5Y-PSZ, and 4Y-PSZ and 5Y-PSZ) and multilayered (3Y-TZP+4Y-PSZ+5Y-PSZ) blocks to be milled as crowns and subjected to physicochemical characterizations and fatigued in graded and non-graded controls. In GAP 3, our aim is to develop a hydrothermal pressure-assisted method to refine 3Y-TZP powder from block-remainders, trashed by commercial labs, and recycle it for restorative use. We shall initiate production of recycled 3Y-TZP and apply it for monolayered, bilayered and multilayered disc-shaped structures, using the group rationale described in GAP 2. Thorough characterization will be performed for controls, graded and a recently developed boron glass infiltration composition. Once we obtain discs from recycled 3Y-TZP with mechanical properties for 3-unit span prostheses (ISO 6872:2015), or higher due to glass infiltration, and with cytotoxicity tests corroborating safe use, we expect that at the end of the 5-year grant we may use the background learned from block production (GAP 2) to apply for recycled 3Y-TZP to fabricate prostheses for needy patients (GAP 3). We have added national and international associate research members that will collaborate with state-of-the-art intellectual and methodology input. Pilot studies are presented to corroborate the feasibility of the current JP-2 grant proposal. (AU)
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