Towards sustainable zirconia recycled from milling waste and boosted by glass infiltration for restorative use, and of the development of strong, graded, and aging resistant multilayered zirconia blocks

• Grant number: 21/06730-7
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• Duration: February 01, 2022 - January 31, 2027
• Field of knowledge: Health Sciences - Dentistry - Dental Materials
• Principal Investigator: Estevam Augusto Bonfante
• Grantee: Estevam Augusto Bonfante
• Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
• Associated researchers: Claudinei dos Santos ; Edmara Tatiely Pedroso Bergamo ; Gilmar Patrocínio Thim ; Lukasz Witek ; Paulo Guilherme Gonçalves Gomes Coelho ; Satoshi Yamaguchi ; Sergio Mazurek Tebcherani ; Tiago Moreira Bastos Campos ; Willian Fernando Zambuzzi
• Associated research grant: 12/19078-7 - Development and processing of Al2O3-ZrO2 translucent composite for CAD/CAM monolithic prostheses: the effect of aging on biaxial flexural strength, AP.JP
• Associated grant(s): 22/05495-7 - Multi-user equipment approved in grant 21/06730-7: ElectroPuls E3000 All-Electric Dynamic Test Instrument, INSTRON, AP.EMU; 22/05496-3 - Multi-user equipment approved in grant 21/06730-7: Macrodurômetro VH1150 - Buehler, AP.EMU
• Associated scholarship(s): 24/10843-0 - Effect of aging and processing on recycled and commercial 3Y-TZP, BP.DR; 23/08712-1 - Glass infiltrated multilayer zirconia: optical, mechanical and hydrothermic stability characterization, BP.DR; 23/03089-4 - MICROSTRUCTURAL AND OPTICAL CHARACTERIZATION OF RECYCLED ZIRCONIA (3Y-TZP) INFILTRATED BY GLASS, BP.IC; + associated scholarships 23/02844-3 - FATIGUE RESISTANCE OF A GLASS INFILTRATED TRANSLUCENT ZIRCONIA (4Y-PSZ) FOR DENTAL APPLICATIONS, BP.IC; 23/00898-9 - Fatigue resistance of an ultra-translucent zirconia (5Y-PSZ) glass infiltrated, BP.IC; 22/12118-5 - Development of the recycling process of 3Y-TZP and application in the production of composites with elastic module gradients, BP.PD; 22/13426-5 - Effect of hydrothermal aging on the physical and mechanical properties of a zirconia system, BP.IC; 22/13513-5 - Effect of hydrothermal aging on the physical and mechanical properties of a translucent zirconia system, BP.IC; 22/07157-1 - Physical and mechanical characterization of a multilayered system using recycled zirconia, BP.PD; 22/07733-2 - Physical and mechanical characterization of a bilayered zirconia system: influence of hydrothermal aging, BP.MS; 22/02470-3 - Fatigue resistance of polycrystalline composites ATZ infiltrated by glass, BP.IC; 20/12874-9 - Infiltration graded by glass in an experimental composite based on whiskers of alumina and zircônia: development, microstructural characterization and optical and mechanical properties, BP.PD - associated scholarships

Abstract

In JP-2 we propose the synthesis of aging resistant, strong and adhesive-friendly polycrystalline multilayered ceramics for monolithic use and to develop a zirconia recycling method to be boosted by glass infiltration in multilayered systems. Our efforts that culminated in prostheses framework developments of JP-1 are called GAP 1. In GAPS 2 and 3 proposed for JP-2, we aim to produce blocks of isolated pristine zirconia powders (3Y-TZP, 4Y-PSZ, and 5Y-PSZ) and their combinations as bilayered (3Y-TZP +4Y-PSZ, 3Y-TZP+5Y-PSZ, and 4Y-PSZ and 5Y-PSZ) and multilayered (3Y-TZP+4Y-PSZ+5Y-PSZ) blocks to be milled as crowns and subjected to physicochemical characterizations and fatigued in graded and non-graded controls. In GAP 3, our aim is to develop a hydrothermal pressure-assisted method to refine 3Y-TZP powder from block-remainders, trashed by commercial labs, and recycle it for restorative use. We shall initiate production of recycled 3Y-TZP and apply it for monolayered, bilayered and multilayered disc-shaped structures, using the group rationale described in GAP 2. Thorough characterization will be performed for controls, graded and a recently developed boron glass infiltration composition. Once we obtain discs from recycled 3Y-TZP with mechanical properties for 3-unit span prostheses (ISO 6872:2015), or higher due to glass infiltration, and with cytotoxicity tests corroborating safe use, we expect that at the end of the 5-year grant we may use the background learned from block production (GAP 2) to apply for recycled 3Y-TZP to fabricate prostheses for needy patients (GAP 3). We have added national and international associate research members that will collaborate with state-of-the-art intellectual and methodology input. Pilot studies are presented to corroborate the feasibility of the current JP-2 grant proposal. (AU)

Scientific publications

(20)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

JALKH, ERNESTO B. BENALCAZAR; BERGAMO, EDMARA T. P.; CAMPOS, TIAGO M. B.; DE ARAUJO-JUNIOR, EVERARDO N. S.; LOPES, ADOLFO C. O.; TEBCHERANI, SERGIO M.; YAMAGUCHI, SATOSHI; GENOVA, LUIS A.; GIERTHMUEHLEN, PETRA C.; WITEK, LUKASZ; et al. Stability of fatigued and aged ZTA compared to 3Y-TZP and Al2O3 ceramic systems. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 135, p. 9-pg., 2022-11-01. (19/08693-1, 17/19362-0, 21/06730-7, 16/17793-1, 19/00452-5, 18/03072-6, 12/19078-7, 16/18818-8, 21/08018-2, 22/07157-1)

NAKASE, YUTARO; YAMAGUCHI, SATOSHI; JALKH, ERNESTO B. BENALCAZAR; ATRIA, PABLO J.; WITEK, LUKASZ; BONFANTE, ESTEVAM A.; LI, HEFEI; SAKAI, TAKAHIKO; OKAWA, RENA; NAKANO, KAZUHIKO; et al. In vitro analysis of durability of S-PRG filler-containing composite crowns for primary molar restoration. Dental Materials, v. 39, n. 7, p. 8-pg., 2023-06-28. (21/06730-7, 19/00452-5, 18/03072-6)

VINICIUS PAVESI FARDIN; GERSON BONFANTE; PAULO G. COELHO; EDMARA T. P. BERGAMO; DIMORVAN BORDIN; MALVIN N. JANAL; NICK TOVAR; LUKASZ WITEK; ESTEVAM A. BONFANTE. Residual stress estimated by nanoindentation in pontics and abutments of veneered zirconia fixed dental prostheses. Journal of Applied Oral Science, v. 30, 2022-04-22. (12/19078-7, 21/08018-2, 14/22859-6, 19/08693-1, 16/18818-8, 11/16377-0, 21/06730-7, 11/23177-8, 13/20806-0)

BERGAMO, EDMARA T. P.; LOPES, ADOLFO C. O.; CAMPOS, TIAGO M. B.; AMORIM, PEDRO HENRIQUE; COSTA, FABIO; BENALCAZAR-JALKH, ERNESTO B.; DE CARVALHO, LAURA F.; ZAHOUI, ABBAS; PIZA, MARIANA M. T.; GUTIERRES, ELIEZER; et al. Probability of survival and failure mode of endodontically treated incisors without ferrule restored with CAD/CAM fiber-reinforced composite (FRC) post-cores. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 136, p. 10-pg., 2022-10-21. (21/06730-7, 19/00452-5, 20/12874-9, 12/19078-7, 21/08018-2, 19/14798-0, 16/18818-8, 20/16500-6, 22/07157-1, 18/03072-6)

BONFANTE, ESTEVAM A.; CALAMITA, MARCELO; BERGAMO, EDMARA T. P.. Indirect restorative systems-A narrative review. Journal of Esthetic and Restorative Dentistry, v. N/A, p. 21-pg., 2023-01-23. (21/06730-7, 16/18818-8, 21/08018-2, 12/19078-7)

BERGAMO, EDMARA T. P.; DE OLIVEIRA, PAULA G. F. P.; JIMBO, RYO; NEIVA, RODRIGO; GIL, LUIZ F.; TOVAR, NICK; WTEK, LUKASZ; BONFANTE, ESTEVAM A.; COELHO, PAULO G.. The Influence of Implant Design Features on the Bone Healing Pathway: An Experimental Study in Sheep. INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY, v. 43, n. 3, p. 8-pg., 2023-05-01. (12/19078-7, 21/06730-7, 19/08693-1)

GUTIERRES, ELIEZER; BERGAMO, EDMARA TATIELY PEDROSO; CARVALHO, LAURA FIRMO; COELHO, PAULO G.; CAMPOS, TIAGO MOREIRA BASTOS; PIZA, MARIANA MIRANDA DE TOLEDO; LOPES, ADOLFO COELHO DE OLIVEIRA; JALKH, ERNESTO BYRON BENALCAZAR; BONFANTE, ESTEVAM AUGUSTO. Single geometry abutment for narrow and extra-narrow implant systems: Survival and failure modes. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 143, p. 9-pg., 2023-05-16. (21/06730-7, 19/08693-1, 22/07157-1, 20/12874-9)

BERGAMO, EDMARA T. P.; CAMPOS, TIAGO M. B.; PIZA, MARIANA M. T.; GUTIERREZ, ELIEZER; LOPES, ADOLFO C. O.; WITEK, LUKASZ; COELHO, PAULO G.; CELESTRINO, MARCOS; CARVALHO, LAURA F. DE; BENALCAZAR, ERNESTO B.; et al. Temporary materials used in prosthodontics: The effect of composition, fabrication mode, and aging on mechanical properties. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 133, p. 10-pg., 2022-07-12. (20/12874-9, 20/16500-6, 21/06730-7, 19/08693-1, 22/07157-1, 21/08018-2, 19/14798-0, 16/18818-8)

BENALCAZAR-JALKH, ERNESTO B.; DE CARVALHO, LAURA F.; ALVES, LARISSA M. M.; CAMPOS, TIAGO M. B.; SOUSA, EDISA DE OLIVEIRA; BERGAMO, EDMARA T. P.; COELHO, PAULO G.; GIERTHMUEHLEN, PETRA C.; SPITZNAGEL, FRANK A.; ZAHOUI, ABBAS; et al. Reliability and Failure Mode of Ti-Base Abutments Supported by Narrow/Wide Implant Systems. DENTISTRY JOURNAL, v. 11, n. 9, p. 11-pg., 2023-09-01. (21/06730-7, 21/08018-2, 20/12874-9, 21/07440-2, 16/18818-8, 19/08693-1, 19/00452-5, 22/07157-1, 18/03072-6)

ALVES, LARISSA M. M.; CAMPOS, TIAGO M. B.; BERGAMO, EDMARA T. P.; BENALCAZAR JALKH, ERNESTO B.; GIERTHMUEHLEN, PETRA C.; SAILER, IRENA; THIM, GILMAR P.; STRAZZI-SAHYON, HENRICO B.; CELESTRINO, MARCOS; GUIMARAES, CAROLINA C. L.; et al. Hydrofluoric acid concentration and etching time affect differently the microstructure and surface properties of pressed lithium disilicate glass ceramics. Journal of Esthetic and Restorative Dentistry, v. N/A, p. 9-pg., 2023-09-29. (21/06730-7, 21/08018-2, 20/12874-9, 21/07440-2, 19/08693-1, 22/07157-1, 22/12118-5)

CHENG, YU-CHI; PERPETUINI, PAOLO; MURCKO, LAURA; HIRAYAMA, MUNEKI; MORGAN, KATHERINE; MARINCOLA, MAURO; BONFANTE, ESTEVAM A.; BERGAMO, EDMARA T. P.; EWERS, ROLF. Fiber-reinforced composite full-arch prosthetic reconstructions supported by three standard, short or extra-short implants: a two-center retrospective study. CLINICAL ORAL INVESTIGATIONS, v. 27, n. 8, p. 13-pg., 2023-05-04. (21/06730-7, 19/08693-1, 21/08018-2)

JALKH, ERNESTO B. BENALCAZAR; RAMALHO, ILANA S.; BERGAMO, EDMARA T. P.; ALVES, LARISSA M. M.; TANAKA, RICARDO; WITEK, LUKASZ; COELHO, PAULO G.; HIRATA, RONALDO; BONFANTE, ESTEVAM A.. Ultrathin lithium disilicate and translucent zirconia crowns for posterior teeth: Survival and failure modes. Journal of Esthetic and Restorative Dentistry, v. N/A, p. 10-pg., 2023-09-07. (21/06730-7, 21/08018-2, 22/05496-3, 21/07440-2, 12/19078-7, 16/18818-8, 19/08693-1, 22/07157-1, 22/05495-7)

FARDIN, VINICIUS P.; BERGAMO, EDMARA T. P.; BORDIN, DIMORVAN; HIRATA, RONALDO; BONFANTE, ESTEVAM A.; BONFANTE, GERSON; COELHO, PAULO G.. Effect of different tightening protocols on the probability of survival of screw-retained implant-supported crowns. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 126, FEB 2022. (21/08018-2, 11/16377-0, 16/18818-8, 13/20806-0, 14/22859-6, 21/06730-7, 11/23177-8)

GOULART, CELSO ANTONIO; PIZA, MARIANA MIRANDA DE TOLEDO; CAMPOS, TIAGO MOREIRA BASTOS; BONFANTE, ESTEVAM AUGUSTO; FILHO LISBOA, PAULO NORONHA. Y-TZP nanostructures with non-homogeneous yttria distribution for improved hydrothermal degradation resistance and mechanical properties. CERAMICS INTERNATIONAL, v. 49, n. 13, p. 13-pg., 2023-05-25. (21/06730-7, 20/12874-9, 22/05496-3, 21/04697-2, 20/16500-6)

CHENG, YU-CHI; BERGAMO, EDMARA T. P.; MURCKO, LAURA; HIRAYAMA, MUNEKI; PERPETUINI, PAOLO; SPERATTI, DRAUSEO; BONFANTE, ESTEVAM A.. Fiber-reinforced composite partial fixed dental prostheses supported by short or extra-short implants: A 10 year retrospective study. CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, v. 24, n. 6, p. 8-pg., 2022-10-07. (19/08693-1, 21/06730-7, 21/08018-2)

ADABO, GELSON LUIS; LONGHINI, DIOGO; BALDOCHI, MARIANA RIBEIRO; BERGAMO, EDMARA TATIELY PEDROSO; BONFANTE, ESTEVAM AUGUSTO. Reliability and lifetime of lithium disilicate, 3Y-TZP, and 5Y-TZP zirconia crowns with different occlusal thicknesses. CLINICAL ORAL INVESTIGATIONS, v. 27, n. 7, p. 12-pg., 2023-04-06. (21/06730-7, 12/19078-7, 16/18818-8, 19/08693-1, 16/09640-0)

BENALCAZAR-JALKH, ERNESTO B.; NAYAK, VASUDEV VIVEKANAND; GORY, CHRISTINA; MARQUEZ-GUZMAN, ANDRES; BERGAMO, EDMARA T. P.; TOVAR, NICK; COELHO, PAULO G.; BONFANTE, ESTEVAM A.; WITEK, LUKASZ. Impact of implant thread design on insertion torque and osseointegration: a preclinical model. MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL, v. 28, n. 1, p. 8-pg., 2023-01-01. (21/06730-7, 19/00452-5, 12/19078-7, 21/08018-2, 16/18818-8, 19/08693-1, 22/07157-1, 18/03072-6)

CHENG, YU-CHI; EWERS, ROLF; MORGAN, KATHERINE; HIRAYAMA, MUNEKI; MURCKO, LAURA; MORGAN, JOHN; BERGAMO, EDMARA T. P.; BONFANTE, ESTEVAM A.. Antiresorptive therapy and dental implant survival: an up to 20-year retrospective cohort study in women. CLINICAL ORAL INVESTIGATIONS, v. 26, n. 11, p. 14-pg., 2022-08-24. (21/06730-7, 19/08693-1)

PARRA, MARCELO; BENALCAZAR JALKH, ERNESTO B.; TOVAR, NICK; TORRONI, ANDREA; BADALOV, RAFAEL M.; BONFANTE, ESTEVAM A.; NAYAK, VASUDEV; CASTELLANO, ARTHUR; COELHO, PAULO G.; WITEK, LUKASZ. The Influence of Surface Treatment on Osseointegration of Endosteal Implants Presenting Decompressing Vertical Chambers: An In Vivo Study in Sheep. INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, v. 37, n. 5, p. 8-pg., 2022-09-01. (21/06730-7, 19/00452-5, 12/19078-7, 16/18818-8, 18/03072-6)

RAÍSSA MONTEIRO PEREIRA; RENATA GUIMARÃES RIBAS; THAÍS LARISSA DO AMARAL MONTANHEIRO; VANESSA MODELSKI SCHATKOSKI; KARLA FAQUINE RODRIGUES; LETÍCIA TERUMI KITO; LUCAS KAZUNORI KOBO; TIAGO MOREIRA BASTOS CAMPOS; ESTEVAM AUGUSTO BONFANTE; PETRA CHRISTINE GIERTHMUEHLEN; et al. An engineering perspective of ceramics applied in dental reconstructions. Journal of Applied Oral Science, v. 31, 2023-02-20. (17/24873-4, 17/27079-7, 21/06730-7, 20/02379-0, 20/12874-9)