Glial cells: Impact on magnetic resonance imaging and seizure frequency of patients with temporal lobe epilepsy

• Grant number: 21/01098-0
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2022
• End date: December 31, 2024
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: José Eduardo Peixoto Santos
• Grantee: José Eduardo Peixoto Santos
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: João Pereira Leite

Abstract

Hippocampal sclerosis is the most common pathology seen in drug-resistant patients. Besides specific alterations in neuronal populations, the epileptogenic hippocampus shows gliosis, which can impact tissue excitability and are linked with the increase in T2 signal and relaxation seen in the epileptogenic hippocampus. Despite the qualitative association between gliosis and T2 signal, quantitative studies failed to show this relationship. The hypothesis of the present proposal is that changes in several glial proteins linked with tissue homeostasis would reflect better the increased T2 signal than merely the intensity of gliosis, measured by GFAP and HLA-DR. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ARRUDA, RIVUS FERREIRA; ARRUDA, IANNE LUCENA; SILVEIRA, RAYANNE M. B.; SARTI, TALITA H. M.; GUILHOTO, LAURA M. F. F.; CARRETE JUNIOR, HENRIQUE; STAVALE, JOAO NORBERTO; PEIXOTO-SANTOS, JOSE EDUARDO; CENTENO, RICARDO SILVA; GUARANHA, MIRIAN S. B.; et al. The challenge of epilepsy surgery and intraoperative neurophysiological monitoring in an underweight young infant. EPILEPTIC DISORDERS, v. 24, n. 6, p. 4-pg., 2022-12-01. (16/17882-4, 21/01098-0)