The relationship between obstructive sleep apnea and its comorbidities with the intestinal microbiome: interface with sexuality and reproductive function

• Grant number: 20/13467-8
• Support Opportunities: Research Projects - Thematic Grants
• Start date: November 01, 2022
• End date: October 31, 2027
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Monica Levy Andersen
• Grantee: Monica Levy Andersen
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Daniela Santoro Rosa ; David Gozal ; Dulce Elena Casarini ; Frida Entezami ; Gabriel Natan de Souza Pires ; Marise Samama ; Renata Mazaro e Costa ; Ronaldo Delmonte Piovezan ; Sergio Tufik
• Associated research grant(s): 23/01555-8 - Sleep disorders, male sexual and fertile function: a cellular and molecular approach, AP.R
• Associated scholarship(s): 25/00662-0 - THE RELATIONSHIP BETWEEN OBSTRUCTIVE SLEEP APNEA AND ITS COMORBIDITIES WITH THE INTESTINAL MICROBIOME: INTERFACE WITH SEXUALITY AND REPRODUCTIVE FUNCTION, BP.PD

Abstract

Poor sleep quality is closely linked to comorbidities in several organic systems. Among sleep disorders, there has been a recent increase in the prevalence of obstructive sleep apnea (OSA) in the population, especially in men. The intermittent hypoxia resulting from OSA can produce physiopathological symptoms, including the impairment of reproductive function, especially in relation to erectile dysfunction (ED) and changes to the hormonal profile that can have a negative impact on the spermatogenic process; and modifications in the gastrointestinal microbiota that can result in a state of dysbiosis, which has also been reported to have a harmful effect on reproductive health. Given these complex biological interrelationships, this thematic project aims to study the impact of OSA on reproductive function and investigate correlations with the gastrointestinal microbiome, both in human subjects and in animal models. Groups of men with or without OSA, treated or not with continuous positive airway pressure (CPAP) therapy, will be compared, and the influence of OSA on reproductive function, either directly or through changes in the gastrointestinal microbiota, will be investigated via hormonal, seminal, genomic, and enteric exosomes analyses. We believe the results of this project will serve as basis for the development of new diagnostic tools in relation to OSA, human fertility and the gastrointestinal microbiota, besides substantially expanding our understanding of the physiopathological interrelations between these topics. The project will also provide evidence to support the development of new therapeutic measures directed to male fertility, including ED, and to the treatment of OSA. (AU)

Scientific publications

(40)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LAVIGNE, GILLES J.; PIRES, GABRIEL NATAN; DAL FABBRO, CIBELE; BABILONI, ALBERTO HERRERO; MARTEL, MARC O.; MORIN, CHARLES M.; ANDERSEN, MONICA LEVY; TUFIK, SERGIO; PALOMBINI, LUCIANA. Doctor, can napping help relieve my pain? Research path to assess the potential benefits/harms of napping for individuals with chronic pain. Sleep, v. 47, n. 4, p. 3-pg., 2024-03-08. (20/13467-8)

ISHIKURA, ISABELA A.; HACHUL, HELENA; TUFIK, SERGIO; ANDERSEN, MONICA L.. Dysmenorrhea and Sleep A Review. SLEEP MEDICINE CLINICS, v. 18, n. 4, p. 13-pg., 2023-10-27. (20/13467-8)

KAKAZU, VIVIANE AKEMI; PINTO, RAFAEL Z.; DOKKEDAL-SILVA, VINICIUS; FERNANDES, GUILHERME LUIZ; ARAUJO, CYNTHIA GOBBI ALVES; PIRES, GABRIEL NATAN; DIAS, TAYNA A.; TUFIK, SERGIO; ANDERSEN, MONICA; MORELHAO, PRISCILA K.. Are Sleep Quality, Daytime Sleepiness and Depression Associated with Knee Pain? A Cross-Sectional Study in Older Adults. SLEEP SCIENCE, v. N/A, p. 6-pg., 2024-06-18. (22/00328-5, 20/13467-8)

SILVA, VINICIUS; BERRO, LAIS; GALDUROZ, JOSE; TUFIK, SERGIO; ANDERSEN, MONICA. GENDER HAS INVERSED ROLES IN A MODEL LINKING LIFETIME SUBSTANCE USE AND SLEEP. Sleep, v. 47, p. 1-pg., 2024-05-01. (20/13467-8)

SILVA, MAYRA; TEMPAKU, PRISCILA; ANDERSEN, MONICA; TUFIK, SERGIO; POYARES, DALVA. THE INFLUENCE OF SEX ON SLEEP CHARACTERISTICS IN THE OLDER ADULT POPULATION: FINDINGS FROM THE EPISONO SLEEP STUDY. Sleep, v. 47, p. 1-pg., 2024-05-01. (20/13467-8)

SOUZA, MAINGREDY RODRIGUES; ROSA, DANIELA SANTORO; ALVARENGA, TATHIANA A.; MORELHAO, PRISCILA K.; TUFIK, SERGIO; ANDERSEN, MONICA L.. Do nocturnal asthma attacks influence sleep parameters and inflammatory markers? A cross-sectional population-based study. Sleep and Breathing, v. 28, n. 2, p. 9-pg., 2023-10-14. (20/13467-8, 21/13004-0)

XAVIER, SANDRA D.; DOKKEDAL-SILVA, VINICIUS; FERNANDES, GUILHERME L.; PIRES, GABRIEL N.; TUFIK, SERGIO; ANDERSEN, MONICA L.. Sleep patterns of children with Cri du Chat syndrome before and during the COVID-19 pandemic: An observational study. RESEARCH IN AUTISM SPECTRUM DISORDERS, v. 116, p. 10-pg., 2024-06-08. (20/13467-8)

XERFAN, ELLEN M. S.; SOUZA, MAINGREDY RODRIGUES; FACINA, ANAMARIA S.; TUFIK, SERGIO; ANDERSEN, MONICA L.. Can good sleep quality enhance the benefits of oral collagen supplementation in the prevention of skin aging? A brief report. ARCHIVES OF DERMATOLOGICAL RESEARCH, v. 317, n. 1, p. 3-pg., 2025-02-06. (20/13467-8)

ADAMI, L.; OLIVEIRA, M.; CUNHA, L.; TUFIK, S.; ANDERSEN, M.. LIPID METABOLISM AND NEUROMUSCULAR JUNCTION AS COMMON PATHWAYS UNDERLYING THE GENETIC BASIS OF ERECTILE DYSFUNCTION AND OBSTRUCTIVE SLEEP APNEA. Sleep Medicine, v. 115, p. 1-pg., 2024-02-01. (21/09089-0, 20/13467-8)

ADAMI, LUANA N. G.; MOYSES-OLIVEIRA, MARIANA; SOUZA-CUNHA, LAIS AMANDA; VASCO, MATHEUS BRANDAO; TUFIK, SERGIO; ANDERSEN, MONICA L.. Lipid metabolism and neuromuscular junction as common pathways underlying the genetic basis of erectile dysfunction and obstructive sleep apnea. INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, v. 36, n. 6, p. 7-pg., 2023-11-21. (23/11995-5, 21/09089-0, 20/13467-8)

MARQUEZINI, BRUNA PEREIRA; MOYSES-OLIVEIRA, MARIANA; KLOSTER, ANNA; CUNHA, LAIS; DECONTO, TAIS BASSANI; MOSINI, AMANDA CRISTINA; GUERREIRO, PEDRO; PASCHALIDIS, MAYARA; ADAMI, LUANA NAYARA GALLEGO; ANDERSEN, MONICA LEVY; et al. Exploring the molecular pathways linking sleep phenotypes and POGZ-associated neurodevelopmental disorder. JOURNAL OF MEDICAL GENETICS, v. 61, n. 6, p. 4-pg., 2024-02-13. (21/09089-0, 20/13467-8)

MOSINI, A. C.; MOYSES-OLIVEIRA, M.; DECONTO, T. B.; PEREIRA MARQUEZINI, B.; GUERREIRO, P.; CUNHA, L.; KLOSTER, A.; PASCHALIDIS, M.; GALLEGO ADAMI, L. N.; ANDERSEN, M. L.; et al. MUTATIONAL MECHANISMS RELATED TO SLEEP DISTURBANCE IN PATIENTS WITH SYNGAP1-ASSOCIATED SYNDROME. Sleep Medicine, v. 115, p. 1-pg., 2024-02-01. (21/09089-0, 20/13467-8)

XERFAN, ELLEN M. S.; FACINA, ANAMARIA S.; TOMIMORI, JANE; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. The influence of phototherapy on circadian melatonin and sleep regulation and potential benefits of these pathways in the management of vitiligo: a narrative review. ARCHIVES OF DERMATOLOGICAL RESEARCH, v. 316, n. 9, p. 8-pg., 2024-09-21. (20/13467-8)

ADAMI, LUANA N. G.; MOYSES-OLIVEIRA, MARIANA; TUFIK, SERGIO; ANDERSEN, MONICA L.. Kinesin binding as a shared pathway underlying the genetic basis of male factor infertility and insomnia. F&S SCIENCE, v. 5, n. 3, p. 7-pg., 2024-08-01. (23/11995-5, 21/09089-0, 20/13467-8)

CAVALCANTE-SILVA, VANESSA; D'ALMEIDA, VANIA; TUFIK, SERGIO; ANDERSEN, MONICA L.. Artificial Intelligence, the Production of Scientific Texts, and the Implications for Sleep Science: Exploring Emerging Paradigms and Perspectives. SLEEP SCIENCE, v. 17, n. 03, p. 3-pg., 2024-07-23. (20/13467-8, 23/08657-0)

MARQUEZINI, B. P.; MOYSES-OLIVEIRA, M.; KLOSTER, A.; CUNHA, L.; DECONTO, T. B.; MOSINI, A. C.; GUERREIRO, P.; PASCHALIDIS, M.; ADAMI, L. N. G.; ANDERSEN, M. L.; et al. EXPLORING THE MOLECULAR PATHWAYS LINKING SLEEP PHENOTYPES AND POGZ-ASSOCIATED NEURODEVELOPMENTAL DISORDERS. Sleep Medicine, v. 115, p. 2-pg., 2024-02-01. (21/09089-0, 20/13467-8)

XAVIER, SANDRA D.; MOYSES-OLIVEIRA, MARIANA; KLOSTER, ANNA KAROLINY; BALBUENO, BIANCA; TUFIK, SERGIO; ANDERSEN, MONICA L.. Evaluation of the Sleep Profile in Children With Cri du Chat Syndrome: A Pilot Study. PEDIATRIC NEUROLOGY, v. 156, p. 2-pg., 2024-04-30. (21/09089-0, 20/13467-8)

MOSINI, AMANDA CRISTINA; MOYSES-OLIVEIRA, MARIANA; DE ARAUJO, JESSICA NAYARA GOES; GUERREIRO, PEDRO; CUNHA, LAIS; ZAMARIOLLI, MALU; XAVIER, SANDRA DORIA; BALBUENO, BIANCA; DE MELLO, CLAUDIA BERLIM; MOREIRA, GUSTAVO ANTONIO; et al. Sleep complaints in individuals with SYNGAP1-associated syndrome. Sleep Medicine, v. 126, p. 8-pg., 2024-12-28. (21/09089-0, 20/13467-8, 24/05023-3, 23/14935-3, 23/09760-0)

VALENTE, HELOISA BALOTARI; MORELHAO, PRISCILA KALIL; RODRIGUES, ANNA JULIA LEAL; BORGES, LAIZA DELATORRE MARDEGAN; DA SILVA, ALESSANDRA APARECIDA ALVES; ANDERSEN, MONICA LEVY; TUFIK, SERGIO; VANDERLEI, LUIZ CARLOS MARQUES. Light therapy as a non-pharmacological intervention to mitigate daytime sleepiness in healthy older adults. Sleep and Breathing, v. 29, n. 1, p. 2-pg., 2025-03-01. (23/11651-4, 20/13467-8)

CUNHA, L.; MARQUEZINI, B. P.; MOYSES-OLIVEIRA, M.; KLOSTER, A.; DECONTO, T. B.; MOSINI, A. C.; GUERREIRO, P.; PASCHALIDIS, M.; ADAMI, L. N. G.; ANDERSEN, M. L.; et al. THE RELATIONSHIP BETWEEN CREBBP VARIANTS AND INSOMNIA: FROM RUBINSTEIN-TAYBI SYNDROME INTO ENERGY METABOLISM. Sleep Medicine, v. 115, p. 2-pg., 2024-02-01. (21/09089-0, 20/13467-8)

MORELHAO, PRISCILA; CAVALCANTE-SILVA, VANESSA; FERNANDES, GUILHERME; D'ALMEIDA, VANIA; TUFIK, SERGIO; ANDERSEN, MONICA. HOMOCYSTEINE AS A PREDICTOR OF APNEA-HYPOPNEA INDEX IN OBSTRUCTIVE SLEEP APNEA: LONGITUDINAL EPIDEMIOLOGICAL STUDY. Sleep, v. 47, p. 2-pg., 2024-05-01. (20/13467-8)

ANDERSEN, MONICA LEVY; GOZAL, DAVID; TUFIK, SERGIO. Exploring the link between comorbid insomnia and sleep apnea (COMISA) and erectile dysfunction: implications for male sexual health. SEXUAL MEDICINE REVIEWS, v. 13, n. 1, p. 11-pg., 2024-10-22. (20/13467-8)

MOSINI, AMANDA CRISTINA; ADAMI, LUANA NAYARA GALLEGO; VALLIM, JULIA RIBEIRO DA SILVA; MOYSES-OLIVEIRA, MARIANA; POYARES, DALVA; ANDERSEN, MONICA L.; TUFIK, SERGIO. Leptin moderates the relationship between sleep quality and memory function: A population-based study. Sleep Medicine, v. 117, p. 6-pg., 2024-03-26. (23/09760-0, 21/09089-0, 20/13467-8)

ANDERSEN, MONICA LEVY; LAVIGNE, GILLES; DAL FABBRO, CIBELE; TUFIK, SERGIO. Erectile dysfunction and sleep related bruxism: An exploratory review of an improbable association. SLEEP MEDICINE REVIEWS, v. 77, p. 12-pg., 2024-07-03. (20/13467-8)

MOYSES-OLIVEIRA, MARIANA; ZAMARIOLLI, MALU; TEMPAKU, PRISCILA F.; GALDUROZ, JOSE CARLOS FERNANDES; ANDERSEN, MONICA L.; TUFIK, SERGIO. Shared genetic mechanisms underlying association between sleep disturbances and depressive symptoms. Sleep Medicine, v. 119, p. 9-pg., 2024-04-18. (21/09089-0, 20/13467-8)

PORCACCHIA, A. SAJ; PIRES, G. N.; ANDERSEN, M. L.; TUFIK, S.. ASSOCIATION BETWEEN SLEEP DISORDERS AND CANCER USING DATA FROM THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY (NHANES) 2005-2014. Sleep Medicine, v. 115, p. 2-pg., 2024-02-01. (20/13467-8, 21/05920-7)

KONDO, JULIA; TEMPAKU, PRISCILA F.; D'ALMEIDA, VANIA; KAKAZU, VIVIANE A.; ANDERSEN, MONICA L.; TUFIK, SERGIO; POYARES, DALVA. Sleep patterns according to genetically determined ethnicity in the population of Sao Paulo, Brazil. Sleep Medicine, v. 113, p. 7-pg., 2023-12-07. (20/13467-8, 22/05430-2)

KLOSTER, ANNA K.; ADAMI, LUANA N. G.; MOYSES-OLIVEIRA, MARIANA; HACHUL, HELENA; ANDERSEN, MONICA L.; TUFIK, SERGIO. Exploring the Link between Premature Ovarian Insufficiency, Insomnia and Circadian Pathways. JORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA, v. 28, n. 4, p. 23-pg., 2024-10-01. (23/11995-5, 21/09089-0, 20/13467-8)

ISHIKURA, I. A.; HACHUL, H.; MOYSES-OLIVEIRA, M.; FERNANDES, G. L.; TUFIK, S.; ANDERSEN, M. L.. REDUCED SLEEP EFFICIENCY, INSOMNIA SYMPTOMS AND FATIGUE DURING MENSES ARE NOT RELATED TO INCREASED INFLAMMATORY MEDIATORS: A POLYSOMNOGRAPHIC STUDY FROM EPISONO. Sleep Medicine, v. 115, p. 1-pg., 2024-02-01. (20/13467-8)

KLOSTER, A.; MOYSES-OLIVEIRA, M. M. -O.; ADAMI, L. N. G.; HACHUL, H.; ANDERSEN, M. L.; TUFIK, S.. EXPLORING THE LINK BETWEEN PREMATURE OVARIAN INSUFFICIENCY, INSOMNIA AND CIRCADIAN PATHWAYS. Sleep Medicine, v. 115, p. 1-pg., 2024-02-01. (21/09089-0, 20/13467-8)

TEMPAKU, PRISCILA FARIAS; D'ALMEIDA, VANIA; ANDERSEN, MONICA LEVY; TUFIK, SERGIO. Sleep is associated with telomere shortening: A population-based longitudinal study. Journal of Sleep Research, v. N/A, p. 9-pg., 2024-07-25. (20/13467-8, 23/08657-0)

VALENTE, HELOISA B.; MORELHAO, PRISCILA K.; ANDERSEN, MONICA L.; TUFIK, SERGIO; VANDERLEI, LUIZ CARLOS M.. The role of chronotype in physical behaviors in individuals with cardiovascular disease. Sleep and Breathing, v. N/A, p. 2-pg., 2023-07-24. (20/13467-8)

FERNANDES, G.; TUFIK, S.; ANDERSEN, M.. PROFILES OF SLEEP-RELATED OUTCOMES IN DISTINCT SLEEPINESS GROUPS. Sleep Medicine, v. 115, p. 1-pg., 2024-02-01. (20/13467-8)

ISHIKURA, ISABELA; PORCACCHIA, ALLAN; HACHUL, HELENA; TUFIK, SERGIO; ANDERSEN, MONICA. FATIGUE, ANXIETY AND HEAVY MENSTRUAL FLOW INTERFERE IN SEVERE INSOMNIA SYMPTOMS OF WOMEN AT REPRODUCTIVE AGE. Sleep, v. 47, p. 2-pg., 2024-05-01. (20/13467-8, 21/05920-7)

CUNHA, LAIS; PASCHALIDIS, MAYARA; MOYSES-OLIVEIRA, MARIANA; MARQUEZINI, BRUNA PEREIRA; DECONTO, TAIS BASSANI; GUERREIRO, PEDRO; KLOSTER, ANNA; MOSINI, AMANDA CRISTINA; ADAMI, LUANA NAYARA GALLEGO; ANDERSEN, MONICA L.; et al. The relationship between neurodevelopmental transcriptional programs and insomnia: From Rubinstein-Taybi syndrome into energy metabolism. Sleep Medicine, v. 112, p. 3-pg., 2023-10-05. (21/09089-0, 20/13467-8)

PASCHALIDIS, M.; MOYSES-OLIVEIRA, M.; KLOSTER, A.; MARQUEZINI, B.; CUNHA, L.; ADAMI, L. N. G.; GUERREIRO, P.; MOSINI, A. C.; ANDERSEN, M. L.; TUFIK, S.. NEUROTRANSMITTER REGULATION AS COMMON PATHWAYS BETWEEN SLEEP PHENOTYPES, RESTLESS LEG SYNDROME AND TOURETTE SYNDROME. Sleep Medicine, v. 115, p. 2-pg., 2024-02-01. (21/09089-0, 20/13467-8)

MOYSES-OLIVEIRA, M.; ANDERSEN, M. L.; TUFIK, S.. X-CHROMOSOME FUNCTIONAL DOSAGE IMPACT NEURONAL MOLECULAR SIGNATURES AND CIRCADIAN REGULATION. Sleep Medicine, v. 115, p. 2-pg., 2024-02-01. (21/09089-0, 20/13467-8)

ANDERSEN, MONICA L.; PIRES, GABRIEL NATAN; TUFIK, SERGIO. The Impact of Sleep: From Ancient Rituals to Modern Challenges. SLEEP SCIENCE, v. 17, n. 02, p. 5-pg., 2024-02-20. (20/13467-8)

ISHIKURA, ISABELA A.; PORCACCHIA, ALLAN SAJ; HACHUL, HELENA; TUFIK, SERGIO; ANDERSEN, MONICA L.. Insomnia Symptoms and Menstrual Health: Is There a Link in Women During Reproductive Phase of Life?. BEHAVIORAL SLEEP MEDICINE, v. 22, n. 5, p. 9-pg., 2024-06-01. (20/13467-8, 21/05920-7)

GUERREIRO, P.; MOYSES-OLIVEIRA, M.; KLOSTER, A.; CUNHA, L.; DECONTO, T. BASSANI; MOSINI, A. CRISTINA; MARQUEZINI, B. PEREIRA; PASCHALIDIS, M.; GALLEGO ADAMI, L. NAYARA; ANDERSEN, M. L.; et al. SLEEP DISTURBANCES ASSOCIATED WITH DEAF1 PATHOGENIC VARIANTS. Sleep Medicine, v. 115, p. 2-pg., 2024-02-01. (20/13467-8, 21/09089-0)