Facial masks based on bacterial cellulose and natural actives for the treatment of melasma

• Grant number: 22/14730-0
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Duration: January 01, 2023 - December 31, 2023
• Field of knowledge: Health Sciences - Pharmacy
• Convênio/Acordo: FINEP - Centelha SP Program
• Principal Investigator: Jhonatan Miguel Silva
• Grantee: Jhonatan Miguel Silva
• Host Company: Bioclivea Cosméticos e Biotecnologia Ltda
• CNAE: Comércio varejista de cosméticos, produtos de perfumaria e de higiene pessoal ; Pesquisa e desenvolvimento experimental em ciências físicas e naturais
• City: Araraquara
• Associated grant(s): 22/16050-6 - Facial masks based on bacterial cellulose and natural actives for the treatment of melasma, AP.PIPE
• Associated scholarship(s): 22/16467-4 - Bacterial cellulose facial masks for the treatment of melasma, BP.PIPE

Abstract

Melasma is the hyperpigmentation of the skin that causes the appearance of spots with brownish tones, of higher incidence in females and mainly on the face, which can cause aesthetic discomfort associated with low self-esteem. The spots are triggered by several factors and are difficult to treat. Bacterial cellulose (BC) is formed by nanofibers in the form of a three-dimensional network and has interesting properties for the medical and cosmetic areas, such as: high purity and biocompatibility, large surface area, high water retention (up to 99%) and the ability to maintain local moisture. It is used in several applications in the biomedical area, in the production of dressings for skin lesions and modified release of drugs. The idea of the proposal is to use CB incorporated with nanoemulsified actives that act with different mechanisms to reduce the formation of melanin, for example: Vitamin C, Ellagic acid (anti-oxidants), Alpha-aburtin (tyrosinase inhibitor), Vitamin E (anti-inflammatory), Niacinamide (melanosome transport inhibitors), salicylic acid (cell renewing), for the production of a controlled release system that keeps the region moist and facilitates the entry of the actives into the skin. (AU)