Advanced magnesium materials for load-bearing applications in Medicine

• Grant number: 21/03756-5
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2022
• End date: September 30, 2025
• Field of knowledge: Engineering - Biomedical Engineering
• Agreement: Czech Science Foundation (GACR)
• Principal Investigator: Andrea Madeira Kliauga
• Grantee: Andrea Madeira Kliauga
• Principal researcher abroad: Peter Minarik
• Institution abroad: Charles University in Prague (CU), Czech Republic
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated researchers: Milos Janecek ; Roberto Braga Figueiredo

Abstract

The project focuses on the development of advanced ultrafine-grained magnesium alloys for biodegradable load-bearing applications in Medicine. Two techniques of severe plastic deformation, namely high-pressure torsion and equal channel angular pressing will beemployed to produce the ultrafine-grained structure. Mg-Zn-Ca and Mg-Li-Y systems containing biocompatible elements are selected as prospective candidates for biomedical applications. The composition and especially microstructure of these ternary alloys will be manipulated to achieve the high corrosion resistance, good mechanical properties and optimum biological response for degradable load-bearing implant material and compared with the performance of the reference commercial biocompatible alloy WE43 (Mg-Y-Nd-Zr). The project will benefit from the synergic participation and complementarity of both partner teams from the Czech Republic and Brazil which combine a deep knowledge of the research subject and the possession of advanced experimental techniques of material characterization. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MEDEIROS, MARIANA P.; CARVALHO, AMANDA P.; ISAAC, AUGUSTA; AFONSO, CONRADO R. M.; JANECEK, MILOS; MINARIK, PETER; CELIS, MAYERLING MARTINEZ; FIGUEIREDO, ROBERTO B.. Using high pressure torsion to process magnesium alloys for biological applications. JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, v. 22, p. 10-pg., 2023-01-01. (21/03756-5)

KURODA, PEDRO A. B.; CARVALHO, AMANDA P.; CARAM, RUBENS; FIGUEIREDO, ROBERTO B.; AFONSO, CONRADO R. M.. Nanostructured bulk HPT β Ti-42Nb alloy as biomaterial for implants obtained directly from micrometric powders. Materials Letters, v. 378, p. 4-pg., 2024-10-25. (18/18293-8, 19/26517-6, 21/03756-5)