Endothelial dysfunction in hypertensive disorders of pregnancy

• Grant number: 21/12010-7
• Support Opportunities: Research Projects - Thematic Grants
• Start date: June 01, 2023
• End date: May 31, 2028
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Valeria Cristina Sandrim
• Grantee: Valeria Cristina Sandrim
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Pesquisadores principais: Carlos Alan Candido Dias Junior ; Ricardo de Carvalho Cavalli
• Associated researchers: Ana Carolina Taveiros Palei ; Arielle Cristina Arena ; Fernando Barbosa Júnior ; Jose Carlos Peraçoli ; Jose Eduardo Tanus dos Santos ; Marcelo Rizzatti Luizon ; Margarida Sâncio da Cruz Fardilha ; Mariane Bertagnolli ; Mattias Carlström ; Montenegro MF ; Subian Ananth Karumanchi
• Associated research grant(s): 24/01935-8 - Endothelial dysfunction in preeclampsia: evaluation of potential new drugs in an in vitro model, AP.R
• Associated scholarship(s): 25/01623-9 - Analysis of Endothelial Dysfunction and Inflammatory Markers in Chronic Hypertensive Pregnant Women Supplemented with Beetroot Extract, BP.TT; 23/12666-5 - Characterization of the clinical profile of normotensive and preeclamptic patients for the study of the relationship between endocrine disruptors and preeclampsia, BP.IC; 23/11925-7 - Endothelial dysfunction in preeclampsia: potential drugs and new pharmacological targets obtained from of "omics" tools, BP.PD; + associated scholarships 23/07589-1 - Blood pressure control in chronic hypertensive pregnant women with beet juice supplementation from the 2nd trimester (BEET_CH), BP.PD; 23/06195-0 - Evaluation of endothelial dysfunction in experimental model of preeclampsia-like symptoms induced by reduction of uterine perfusion pressure (RUPP) in pregnant rats, BP.DD; 23/06651-5 - Study of endocrine disruptors (EDRs) and sex hormones in PE., BP.PD - associated scholarships

Abstract

It is likely that the Endothelial Dysfunction (ED) found in Hypertensive Disorders of Pregnancy (HDP) are evoked by the actions of multiple factors and several pathways. Then the discovery and the understanding of these converging pathways that contribute to ED and poor outcome of pregnancy can addressing potential molecules with are modulated by different drugs. The use of omics tools, such as transcriptome and proteome, may help in this field. Importantly, although the knowledge of ED in HDP and the mechanisms underlying these processes are now becoming increasingly understood, this is not corresponding to developments in drug development/uses. There are no investments of pharmacy industries in this field due probably to high-risk investment in pregnant treatment. Moreover, even with improvement in researches on the pathophysiology of gestational hypertensive diseases, drug therapy remains limited and, therefore, is a contributing factor to the maintenance of high rates of maternal mortality. Therefore, the current proposal will explore ED in HDP. We have divided it into five subprojects:SP1 - Endothelial dysfunction in pre-eclampsia: potential drugs and new pharmacological targets obtained from "omics" toolsSP2 - Blood pressure control in chronic hypertensive pregnant women with beetroot juice supplementation starting in the 2nd trimester (BEET_CH)SP3 - Evaluation of endothelial dysfunction in experimental model of preeclampsia-like symptoms induced by reduction of uterine perfusion pressure (RUPP) in pregnant ratsSP 4- Study of endocrine disruptors and sex hormones in PE (EDRs)SP 5 - Biomarkers and pharmacogenetics of antihypertensive therapy in preeclampsia. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PINTO-SOUZA, CAROLINE C.; KAIHARA, JULYANE N. S.; NUNES, PRISCILA R.; MASTELLA, MOISES H.; ROSSINI, BRUNO C.; CAVECCI-MENDONCA, BRUNA; CAVALLI, RICARDO DE CARVALHO; DOS SANTOS, LUCILENE D.; SANDRIM, VALERIA C.. Different Proteomic Profiles Regarding Antihypertensive Therapy in Preeclampsia Pregnant. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 25, n. 16, p. 16-pg., 2024-08-01. (22/07605-4, 23/11925-7, 21/12010-7, 23/08897-1)

DOS SANTOS, CAMILA MACIEL; GONCALVES, PALOMA LETICIA; DE OLIVEIRA, TAMARA ANASTACIO; TEIXEIRA, CLECIA DIAS; BARBOSA, PRISCILA OLIVEIRA; DA SILVA, RAFAELA ROSA; PEDRO, CAROL CONSTANTINO; BREGUEZ, GUSTAVO SILVEIRA; DE SOUZA, MELINA OLIVEIRA. Daily supplementation with guarana powder (Paullinia cupana) modifies short-chain fatty acid concentration and reduces total cholesterol and serum glucose in young rats. NUTRIRE, v. 50, n. 1, p. 10-pg., 2025-04-04. (23/07589-1, 21/12010-7)

RODRIGUES, SERGINARA DAVID; DA SILVA, MARIA LUIZA SANTOS; MARTINS, LAISLA ZANETONI; GOMES, SASKIA ESTELA BIASOTTI; MARIANI, NOEMIA A. P.; SILVA, ERICK J. R.; KUSHIMA, HELIO; MATTOS, BRUNA RAHAL; RIZZI, ELEN; DIAS-JUNIOR, CARLOS ALAN. Pregnancy hypertension-associated endothelial dysfunction is attenuated by isoflurane anesthesia: Evidence of protective effect related to increases in nitric oxide. Life Sciences, v. 331, p. 13-pg., 2023-10-15. (21/12010-7, 20/03135-8, 22/10773-6, 21/03792-1, 21/08380-3)

MARTINS, LAISLA ZANETONI; DA SILVA, MARIA LUIZA SANTOS; RODRIGUES, SERGINARA DAVID; GOMES, SASKIA ESTELA BIASOTTI; MOLEZINI, LAURA; RIZZI, ELEN; MONTENEGRO, MARCELO FREITAS; DIAS-JUNIOR, CARLOS ALAN. Sodium Nitrite Attenuates Reduced Activity of Vascular Matrix Metalloproteinase-2 and Vascular Hyper-Reactivity and Increased Systolic Blood Pressure Induced by the Placental Ischemia Model of Preeclampsia in Anesthetized Rats. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 16, p. 16-pg., 2023-08-01. (21/12010-7, 20/03135-8, 22/10773-6, 21/03792-1, 21/08380-3)

VIANA-MATTIOLI, SARAH; FONSECA-ALANIZ, MIRIAM HELENA; PINHEIRO-DE-SOUSA, IGUARACY; KRIEGER, JOSE EDUARDO; SANDRIM, VALERIA CRISTINA. Missi ng links in preeclampsia cell model systems of endothelial dysfunction. TRENDS IN MOLECULAR MEDICINE, v. 29, n. 7, p. 13-pg., 2023-07-01. (19/07230-8, 21/12010-7)

VIANA-MATTIOLI, SARAH; FONSECA-ALANIZ, MIRIAM HELENA; PINHEIRO-DE-SOUSA, IGUARACY; ROSA JUNIOR, RICARDO; MASTELLA, MOISES HENRIQUE; CAVALLI, RICARDO DE CARVALHO; SANDRIM, VALERIA CRISTINA. Plasma from hypertensive pregnancy patients induce endothelial dysfunction even under atheroprotective shear stress. SCIENTIFIC REPORTS, v. 15, n. 1, p. 15-pg., 2025-02-08. (21/12010-7, 23/11925-7, 19/07230-8)

KAIHARA, JULYANE N. S.; DE MORAES, FABIO ROGERIO; NUNES, PRISCILA REZECK; ALVES, MARCO G.; CAVALLI, RICARDO C.; TASIC, LJUBICA; SANDRIM, VALERIA CRISTINA. Plasma metabolic profile reveals signatures of maternal health during gestational hypertension and preeclampsia without and with severe features. PLoS One, v. 19, n. 11, p. 22-pg., 2024-11-26. (23/08897-1, 18/24069-3, 19/07230-8, 21/12010-7)

NUNES, PRISCILA R.; OLIVEIRA, PEDRO F.; REBELO, IRENE; SANDRIM, VALERIA C.; ALVES, MARCO G.. Relevance of real-time analyzers to determine mitochondrial quality in endothelial cells and oxidative stress in preeclampsia. VASCULAR PHARMACOLOGY, v. 155, p. 12-pg., 2024-04-09. (22/07226-3, 21/12010-7)