Bioactive and resorbable PDO/bioglass membranes obtained by 3D printing for guided tissue regeneration

• Grant number: 23/01557-0
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2024
• End date: June 30, 2026
• Field of knowledge: Health Sciences - Dentistry
• Agreement: CNPq
• Principal Investigator: Luana Marotta Reis de Vasconcellos
• Grantee: Luana Marotta Reis de Vasconcellos
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil
• Associated research grant: 21/05274-8 - Drug delivery sistem in injetable and 3D impress hidrogel to bone repair in ovariectomized rats, AP.R
• Associated scholarship(s): 23/16554-7 - Development of multilayer cellular scaffolds containing a bioactive glass with hierarchical pore structure by combining electrospinning and additive manufacturing techniques for applications in regenerative medicine, BP.JD

Abstract

Used in several clinical situations to facilitate the repair of bone and periodontal defects, guided tissue regeneration (GTR) uses polymeric biocompatible membranes in order to prevent the migration of connective and epithelial tissues to the wound, allowing periodontal ligament cells to repopulate the surface root canal and regenerate the tooth insertion apparatus. To add new properties to the membranes, other biomaterials, such as bioglass, can be added to these polymeric matrices. Among the materials used to manufacture membranes, the polymer polydioxanone (PDO) stands out due to its form of degradation and biocompatibility. Silicate-based bioglass stands out due to its excellent bioactivity, and it can also be modified with a variety of therapeutic ions. In this context, the present research project consists in the fabrication and characterization of PDO/Bioglass membranes aiming applications in the dental field. Modifications in the composition of the 58S-derived bioglass will be carried out through the incorporation of small amounts (5-10% by mass) of some therapeutic ions (silver and zinc), with the objective of promoting an improvement in the biological characteristics of the material. The bioglass powders obtained by the sol-gel technique will be characterized in terms of their physical, chemical and structural properties. Membranes will be prepared by 3D printing and characterized as their physical, mechanical and biological properties (in vitro assays of antimicrobial activity). In this way, it is expected to obtain bioactive and resorbable PDO membranes containing bioglass modified with therapeutic ions aiming applications in periodontal regeneration. (AU)