Polycaprolactone/Biosilicate® membranes for guided bone tissue regeneration

• Grant number: 15/21071-9
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Effective date (Start): June 10, 2016
• Effective date (End): September 09, 2016
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Ana Claudia Muniz Renno
• Grantee: Hueliton Wilian Kido
• Supervisor: Na Yu
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
• Research place: Nanyang Technological University, Singapore
• Associated to the scholarship: 14/23471-1 - Bioglass/colagen scaffolds enriched with mesenchymal stem cell: effects on the repair of critical defects in rat calvaria, BP.PD

Abstract

Periodontitis is a major chronic inflammatory disorder that can lead to the destruction of the periodontal tissues and, ultimately, tooth loss. To date, flap debridement and/or flap curettage and periodontal regenerative therapy with membranes and bone grafting materials have been employed with distinct levels of clinical success. Current resorbable and non-resorbable membranes act as a physical barrier to avoid connective and epithelial tissue down-growth into the defect, favoring the regeneration of periodontal tissues. These conventional membranes possess many structural, mechanical, and bio-functional limitations and the "ideal" membrane for use in periodontal regenerative therapy has yet to be developed. Based on these considerations, a new Polycaprolactone/Biosilicate® membrane will be developed as a treatment strategy for periodontal disease. The introduction of BG will be designed to integrate its high bioactivity rate to the material, increasing the material osteogenic potential, whereas the PCL will be used to improve the mechanical property and absorption rate of the composite. Despite these possible advantages, there is still limited understanding of the interactions between the component phases of the composite. Consequently, the aim of the current study is to investigate the physico-chemical and morphological properties of PCL/BG membranes. To this end, PCL/BG membranes will be evaluated by means of XRD characterization, scanning electron microscopy (SEM), mechanical testing, in vitro degradation studies and in vitro cell culture test (cell proliferation and differentiation).