Abstract
Aquaculture is expanding in Brazil and in the world and pathologies associated with the increase in fish production have been growing proportionally, which highlights the need to invest in new treatment technologies aimed at quality and added value. In this sense, this project aims at the application development of biocompatible and biodegradable nanoparticles as drug carriers for oral administration in consumption fish for parasitic treatments. The nanoparticles will be developed with biopolymers providing: effective encapsulation of antiparasitic drugs; high palatability for oral administration to fish, improving efficiency, minimizing losses and avoiding water pollution; protection against drug degradation in gastric juice; reduction or elimination of toxicity; mucoadhesion in the intestinal mucosa, optimizing drug release in the intestine and achieving high bioavailability, resulting in efficient treatments and at the same time reducing the chances for pathogen resistance generation. Physicochemical, in vitro and in vivo studies will be carried out aiming at the development of nanotechnology in the treatment of parasites that affect the production of tilapia (Oreochromis niloticus) and tambaqui (Colossoma macropomum). The project aims at the effective application of a parasite treatment system with commercial appeal and potential application in aquaculture. Fundamentally, the project proposes the use of nanotechnology as a new strategy in fish production. (AU)
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