Effect of Citral on periodontal disease in rats

• Grant number: 22/12290-2
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2023
• End date: September 30, 2025
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Luiz Guilherme de Siqueira Branco
• Grantee: Luiz Guilherme de Siqueira Branco
• Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• City of the host institution: Ribeirão Preto

Abstract

Periodontitis is an inflammatory, non-communicable disease that affects the protective and supporting tissue, and presents scaling and root planing as standard treatment. In recent years, different therapeutic strategies have been proposed for the adjuvant treatment of periodontal diseases, but little is known about how natural substances can interact with the progression of periodontal disease and the host's immune response. The present project aims to expand the knowledge about the action of new substances on inflammatory mechanisms involved in periodontal disease, particularly in the face of periodontitis induction in rats. Studies show the anti-inflammatory and antibacterial action of Citral, which is a mixture of essential oil present in plants such as lemongrass and ginger, but there are no reports on the possible effect of Citral on periodontitis. Therefore, this study intends to evaluate the action of Citral in periodontitis, using the periodontitis model accepted by the scientific community for the study of periodontal inflammation, that is, ligature-induced periodontitis in rats. 108 Wistar Hannover rats will be selected, divided into 6 groups (n=9). After 3 and 15 days of ligation, the concentration of plasma and gingiva cytokines, bone support and metalloproteinases (MMP-2 and MMP-9) will be evaluated. The results of this project will be important in the field of dentistry, bringing new substances to the treatment of periodontitis. (AU)

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

BRANCO, LUIZ; SANTOS, WANDESRON; CARNIO, EVELIN. Citral reduces alveolar bone loss and inflammatory mediators in ligature-induced periodontitis: implications for novel therapeutic strategies. PHYSIOLOGY, v. 40, p. 2-pg., 2025-05-01. (22/12290-2, 23/08395-6)

TRAJANO, ISIS P.; COSTA, LUIS HENRIQUE ANGENENDT; PASSAGLIA, PATRICIA; SANTOS, WANDERSON S.; DOS SANTOS, JONATHAS RODRIGO; ALBERICI, LUCIANE CARLA; BRANCO, LUIZ G. S.. Fluoxetine mitigates hypothermia and inflammatory responses in lipopolysaccharide-induced systemic inflammation: Insights into serotonergic and hypothalamic thermoregulatory mechanisms. CYTOKINE, v. 189, p. 7-pg., 2025-03-08. (22/01783-8, 22/12290-2, 16/17681-9)