Effect of cross-hormonization on renal function and morphology in rats: emphasis on the changes of renal sodium transporters expression and its relationship with the development of systemic arterial hypertension.

• Grant number: 23/01827-8
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2023
• End date: November 30, 2025
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Guiomar Nascimento Gomes
• Grantee: Guiomar Nascimento Gomes
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Magnus Régios Dias da Silva

Abstract

Cross-hormone therapy (THC) has been used by transgender people for the modification of sexual characteristics. Trans-men have been using androgenic steroids (EA) while trans-women have been using estrogen, associated or not with progestogen. Recently, in our laboratory, we evaluated male and female Wistar rats submitted to THC mimicking the conditions of trans men and women. We observed significant renal morphological alterations; however the effects on glomerular and tubular function of rats under these conditions need to be expanded, in order to establish the effects of THC on renal hemodynamics and tubular function in this experimental model. The incidence of chronic kidney disease in the world is increasing, therefore the investigation into the impact of THC in the predisposition to the development of renal alterations and development of arterial hypertension becomes relevant. Thus, the objectives of this work are: 1) to evaluate the effects of chronically administered THC in rats (male and female) on blood pressure (BP), and functional parameters of the kidneys (glomerular filtration rate, renal plasma flow, acid excretion, etc.) and on renal morphological aspects (glomerular area, renal cross-sectional area, expression of markers of renal injury and expression of tubular sodium transporters). (AU)