Evaluation of bone regeneration in response to different macro and microstructures of implants: a microtomographic and histomorphometric study in rabbits.

• Grant number: 23/11553-2
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2024
• End date: June 30, 2026
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Sérgio Luís Scombatti de Souza
• Grantee: Sérgio Luís Scombatti de Souza
• Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The discovery of osseointegration by Branemark enabled patient rehabilitation through stable bone-implant fixation, initially achieved by primary stability. Factors like macrostructure, thread design, healing, and implant roughness can influence this connection. While promising studies acknowledge these features, none correlate implant macro and microstructures. Our study aims to assess how different combinations of these elements affect osseointegration. We will use 24 New Zealand rabbits, randomly divided into 6 experimental groups of 12 animals each. Groups will be euthanized after 3 and 8 weeks. Implants will be randomly placed in positions A and B on the rabbits' right and left tibiae. The StrongDAA, EpikutDAA, and UnititeDAA groups will have distinct macrogeometries but the same dual acid etching (DAA) surface treatment. Similarly, the StrongNanoHA, EpikutNanoHA, and UnititeNanoHA groups will differ in macrogeometries and share a nano-hydroxyapatite (NanoHA) surface treatment. After euthanasia, peri-implant areas will undergo three-dimensional analysis through microtomography and histomorphometry. Simple Analysis of Variance and Tukey's post hoc test (for normal distribution) or Wilcoxon's Test (for non-normal) will compare groups, with a significance level of 5% (p < 0.05). (AU)