Use of deep eutectic solvents in sustainable spectrophotometric and electroanalytical procedures

• Grant number: 24/04116-8
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2024
• End date: July 31, 2026
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Orlando Fatibello Filho
• Grantee: Orlando Fatibello Filho
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated researchers: Éder Tadeu Gomes Cavalheiro
• Associated scholarship(s): 24/13620-1 - Determination of emerging contaminants employing electrochemical sensors modified with metallic nanoparticles synthesized in natural deep eutectic solvents, BP.DD

Abstract

Our research group has been investigating the syntheses and applications of deep eutectic solvents (DES) in solid-liquid or liquid-liquid microextractions of various analytes in food, environmental, biological, and pharmaceutical samples. After separating the analyte from the sample matrix and pre-concentration, its determination can be made by spectrophotometry, digital image colorimetry using smartphones or by an electroanalytical technique. Conventional separation and preconcentration procedures usually involve high volumes of organic solvents, produce large amounts of waste and are generally time-consuming. DES have emerged as a greener and more sustainable alternative to replace organic solvents with high toxicity and volatility, in addition to being low-cost, easy to obtain and their preparation does not generate by-products (100% atomic economy). For these reasons, DES have been studied in several analytical applications. One of the numerous applications of DES involves the syntheses of metallic nanoparticles for use in electrochemical sensors. In our laboratories, we recently synthesized ultrasmall platinum nanoparticles (USPtNPs) with a diameter of 0.204 nm, which were used to modify a glassy carbon electrode for the determination of riboflavin. In the present proposal, the syntheses of several ultrasmall metal nanoparticles (USMNPs) such as Au, Ir, Pt, Ag, CeO2, Cu, Ni and iron oxides (Fe3O4 (magnetite) and Fe2O3 (hematite)) will be investigated, having different DES as reaction medium. Next, the nanoparticles will be used in the manufacture of electrochemical sensors for the determination of analytes in different matrices. In these studies, DES characterizations will be carried out using Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), as well as measurements of viscosity, conductivity, and water content. In addition, characterization of the nanoparticles will be carried out by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The elaborated sensors will be studied using voltammetric techniques (cyclic, differential pulse and square wave), amperometry and electrochemical impedance spectroscopy (EIS). Furthermore, in our group, electroanalytical procedures are also being developed directly in the DES. In other words, after microextraction and pre-concentration of the analyte under study, the DES itself serves as a supporting electrolyte. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AUGUSTO, KAREN K. L.; BERNALTE, ELENA; CRAPNELL, ROBERT D.; ANDREWS, HAYLEY G.; FATIBELLO-FILHO, ORLANDO; BANKS, CRAIG E.. Sustainable silver nanoparticle-enhanced additive manufactured sensor for cadmium (II) sensing in environmental waters. JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING, v. 13, n. 3, p. 8-pg., 2025-06-01. (24/04116-8)

AUGUSTO, KAREN KENLDERI DE LIMA; GOMES-JUNIOR, PAULO CARDOSO; LONGATTO, GUSTAVO PATELLI; PICCIN, EVANDRO; CAVALHEIRO, EDER TADEU GOMES; BERNALTE, ELENA; BANKS, CRAIG E.; FATIBELLO-FILHO, ORLANDO. Electrochemical sensor based on carbon nanohorns and hydrophobic deep eutectic solvent for the determination of serotonin in biological samples. Electrochimica Acta, v. 520, p. 10-pg., 2025-04-20. (24/04116-8, 24/13620-1)

GOMES-JUNIOR, PAULO CARDOSO; LONGATTO, GUSTAVO PATELLI; AUGUSTO, KAREN KENLDERI DE LIMA; ROCHA, JOSIAS DA SILVEIRA; PICCIN, EVANDRO; FATIBELLO-FILHO, ORLANDO. Synthesis of ultrasmall cerium oxide nanoparticles in deep eutectic solvent and their application in an electrochemical sensor to detect dopamine in biological fluid. Microchimica Acta, v. 191, n. 7, p. 12-pg., 2024-07-01. (22/15513-2, 19/22217-8, 24/04116-8)

DA PENHA, GEOVANNA MORGADO; PEREIRA, AIRTON VICENTE; TAVARES, EMILY AMABILE; DOS SANTOS JR, DANIEL ALMEIDA; FATIBELLO-FILHO, ORLANDO. Microplate-based 3D-printed image box for urea determination in milk by digital image colorimetry. ANALYTICAL METHODS, v. 16, n. 33, p. 8-pg., 2024-08-05. (24/04116-8)

GOMES-JUNIOR, PAULO CARDOSO; NASCIMENTO, EVAIR DIAS; AUGUSTO, KAREN KENLDERI DE LIMA; LONGATTO, GUSTAVO PATELLI; FARIA, RONALDO CENSI; PICCIN, EVANDRO; FATIBELLO-FILHO, ORLANDO. Voltammetric determination of uric acid using a miniaturized platform based on screen-printed electrodes modified with platinum nanoparticles. Microchemical Journal, v. 207, p. 8-pg., 2024-10-19. (22/15513-2, 19/22217-8, 24/04116-8)