| Grant number: | 16/50009-2 |
| Support Opportunities: | Regular Research Grants |
| Start date: | August 01, 2016 |
| End date: | July 31, 2018 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Organic Chemistry |
| Agreement: | Australian Technology Network of Universities (ATN) |
| Mobility Program: | SPRINT - Projetos de pesquisa - Mobilidade |
| Principal Investigator: | Vanderlan da Silva Bolzani |
| Grantee: | Vanderlan da Silva Bolzani |
| Principal researcher abroad: | EMILY FRANCES HILDER |
| Institution abroad: | University of South Australia (UniSA) , Australia |
| Host Institution: | Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil |
| City of the host institution: | Araraquara |
| Associated research grant: | 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery, AP.CEPID |
Abstract
Recent technological advances in the so called genomics era have been revitalizing the exploitation of the value of natural products as starting points for drug discovery. The rational exploitation of biodiversity offers significant economic opportunities to Brazil and Australia. One of the most challenging steps in chemical investigations of complex natural samples is sample preparation. Whereas the success of the chromatographic or spectrophotometric analysis relies on the quality of the sample presented to the analytical system, the greenness of the overall process is strongly impacted by this key step. This is because the common solvents used for extraction purposes are toxic to the environment. Natural deep eutectic solvents (NADES) appear as potential green extraction media for natural products, but the recovery of the bioanalytes from the NADES enriched extract is still limiting. The goal of this collaborative project is to develop alternative, sustainable approaches for sample preparation of complex natural samples investigated under the ongoing CIBFar. Cheap, sustainable, and safe NADES and tailor-made polymeric adsorbents will be used during plant extraction and analyte recovering procedures and the efficiency of both procedures will be monitored by high performance liquid chromatography and Nuclear Magnetic Resonance. The performances of the developed strategies and methods will be compared to those previously developed under the ongoing CIBFar project by using traditional solvents. (AU)
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