Peptide Biodiversity: Advancing Human Health Through Nature's Pharmacological Treasures

• Grant number: 24/18442-4
• Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants
• Start date: March 01, 2025
• End date: February 29, 2028
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Vanderlan da Silva Bolzani
• Grantee: Vanderlan da Silva Bolzani
• Principal researcher abroad: Michael Freissmuth
• Institution abroad: Medical University of Vienna, Austria
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated scholarship(s): 25/08311-2 - MALDI-TOF-MSI, a cutting-edge analytical approach for mapping orbitides and cyclotides in plant species from the Amazonia, BP.PD

Abstract

The Biodiversity2Drugs European Program aims to identify peptides in species from Terrestrial biodiversity organisms, an important class of natural products, unexplored for discovering nature's hits/leads, aiming for pharmacological prototypes, that could impact the pharmaceutical section in European Community and global competitiveness, through a sustainable and ecologically development. Brazil will be responsible for characterizing peptides isolated from plants species from the Cerrado and the Atlantic Forest, and also for carrying out the synthesis of peptides with pharmacological potential. It also aims to study the chemical mapping of these peptides, aiming to understand the interactions of this class of natural products and their ecological and evolutionary aspects. (AU)