Development of Innovative Nano-Phytotherapeutic Formulations: Nanoformulation of Boswellia Serrata for delivery in different pharmaceutical forms.

• Grant number: 24/08101-5
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Start date: June 01, 2025
• End date: February 28, 2026
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Viviane Aparecida Guilherme Damasio
• Grantee: Viviane Aparecida Guilherme Damasio
• Company: Fornano Soluções Nanotecnológicas e Quimiométricas Ltda
• CNAE: Pesquisa e desenvolvimento experimental em ciências físicas e naturais
• City: Campinas
• Associated researchers: Eneida de Paula

Abstract

The proposal in question aims to achieve several important objectives in the area of nanotechnology applied to herbal compounds, focusing on the development of a matrix of nanostructured lipid carriers containing Boswelia Serrata. The main objectives are to evaluate the technical-scientific feasibility of this matrix, carry out its freeze-drying while maintaining the properties of the nanoparticles, develop an orodispersible film containing the nanoparticles and capsules comparable with commercial inputs. It is noteworthy that phytochemical compounds incorporated into nanoparticles have emerged as a promising alternative on the market, aiming to improve the bioavailability and effectiveness of natural compounds.Boswellia Serrata, known for its anti-inflammatory and immunomodulatory benefits, is an example. Brazilian legislation, although strict, offers a window of opportunity for therapeutic innovations, such as those proposed in this project. Regarding competitors and intellectual property, while international companies offer innovative products such as liposomes and phytosomes, some gaps persist in the national market. Patent analysis reveals an opportunity for innovation in the area of nanostructured lipid carriers associated with herbal compounds. The proposal stands out for offering not only the active ingredient, but also final products in various pharmaceutical forms, meeting consumer demands. In this project we propose the development of the nanoparticle matrix, including the preparation of nanostructured lipid carriers, optimization of the formulation by factorial design and characterization of the nanoparticles.The freeze-drying of the matrix is addressed next, with the preparation of the freeze-dried matrices and their subsequent characterization. Finally, the development of the orodispersive film and capsules, together with their characterization according to pharmacopoeial parameters, completes the plan. The development of nanoparticles, including formulation optimization and freeze-drying, will be essential to ensure the stability and effectiveness of active compounds. The preparation of the orodispersive film and capsules will allow the production of diversified pharmaceutical forms, meeting consumer preferences and opening up new market opportunities. The detailed characterization of these products will guarantee their quality and compliance with regulatory standards. In summary, the proposal presents a comprehensive and innovative approach to the development of nanostructured herbal compounds, taking advantage of gaps in the national market and exploring new technologies to offer effective and affordable therapeutic solutions. The detailed research plan outlines the steps necessary to achieve these goals, from nanoparticle preparation to product characterization, demonstrating a commitment to quality and scientific excellence. (AU)