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PH and temperature sensitive drug nanocarriers for skin applications

Grant number: 17/24402-1
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): July 01, 2018
Status:Discontinued
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Daniele Ribeiro de Araujo
Grantee:Estefânia Vangelie Ramos Campos
Home Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Associated research grant:14/14457-5 - Lipid-based nanocarriers (SLN/NLC and remote-loading liposomes) used to improve the upload and potency of local anesthetics, AP.TEM
Associated scholarship(s):19/05100-0 - Evaluation of the biological activity of topical formulations of budesonide in inflammatory skin models, BE.EP.PD

Abstract

Smart drug carrier systems have the objective of modifying the limiting physicochemical properties of the drugs, enhancing their therapeutic effect, controlling their absorption and distribution in the tissues and reducing the toxicological effects. Nanoencapsulation of bioactive molecules and their subsequent mobilization in semi-solid topical formulations is a technologically viable alternative to modulate the permeation of these drugs through the skin. Within this context, the main objective of this project is to develop carrier systems that are pH and / or temperature sensitive in order to improve the availability and therapeutic efficiency of formulations for local drug delivery (topical administration), using benzocaine as a model drug. In the first stage of its execution will be prepared and characterized colloidal dispersions (nanoparticles and polymeric micelles) fluorescently labeled or not and will be evaluated for physical-chemical stability, not only along the time of storage, but also at different pH and temperatures. Next, the incorporation of these nanoformulations into hydrogel systems will be studied and their in vitro release and permeation kinetics will be carefully evaluated. In vitro cell cytotoxicity and uptake assays will be performed to evaluate the toxicity of these systems as well as the distribution of these nanoparticles. In this way, the development of carrier systems that are capable of improving the bioavailability and pharmacokinetics of drugs through the topical route is expected with the execution of this project.