Evaluation of the clinical and molecular repercussions of the use of contraceptives that contain only progestogen

• Grant number: 03/08391-7
• Support Opportunities: Research Projects - Thematic Grants
• Start date: August 01, 2004
• End date: November 30, 2009
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Luis Guillermo Bahamondes
• Grantee: Luis Guillermo Bahamondes
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Pesquisadores principais: Carlos Alberto Petta
• Associated scholarship(s): 09/04603-6 - Chronic pelvic pain and contipation, BP.MS; 07/07866-2 - Effect of the levonorgestrel as emergency contraceptive on the number, motility and the acrossomal reaction rate of spermatozoa rate recovered from the uterine tuba, BP.DR

Abstract

There exists a trend towards the use of contraceptive methods with just progestogen, among which implants, emergency contraception and SIU-LNG. With the increase in use, clinical evaluation has become important. This project aims to study aspects of contraceptive implants as endometrial alterations in women with and without bleeding, via metalloproteinase expression and micro-array (cDNA). Also the prevalence of persistent ovarian follicles will be evaluated, a fact more frequent during the use of these methods. In addition to this we will evaluate the effect of the implants on bone mass in prospective form. We have also studied emergency contraception with levonorgestrel, regarding the acrosome reaction in vitro. We wish to study the influx of calcium and the acrosome reaction in vivo in spermatozoids obtained from a uterine wash from women after the use of emergency contraception. Finally, the project also proposes new studies with the three monthly injectable medroxiprogesteron, evaluating the function of the isoforms of FSH during the use of this method. (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CANTEIRO, RENATA; BAHAMONDES, M. VALERIA; FERNANDES, ARLETE DOS SANTOS; ESPEJO-ARCE, XIMENA; MARCHI, NADIA M.; BAHAMONDES, LUIS. Length of the endometrial cavity as measured by uterine sounding and ultrasonography in women of different parities. Contraception, v. 81, n. 6, p. 515-519, JUN 2010. (03/08391-7)

BERNARDES, NICOLE DE OLIVEIRA; MARQUES, ANDREA; GANUNNY, CAMILA; BAHAMONDES, LUIS. Use of Intravaginal Electrical Stimulation for the Treatment of Chronic Pelvic Pain A Randomized, Double-Blind, Crossover Clinical Trial. JOURNAL OF REPRODUCTIVE MEDICINE, v. 55, n. 1-2, p. 19-24, JAN-FEB 2010. (03/08391-7)

LORETI, NAZARETH; AMBAO, VERONICA; JULIATO, CASSIA TEATIN; MACHADO, CECILIA; BAHAMONDES, LUIS; CAMPO, STELLA. Carbohydrate complexity and proportion of serum FSH isoforms reflect pituitary-ovarian activity in perimenopausal women and depot medroxyprogesterone acetate users. CLINICAL ENDOCRINOLOGY, v. 71, n. 4, p. 558-565, OCT 2009. (03/08391-7)

PELOGGIA, ALESSANDRA; PETTA, CARLOS A.; BAHAMONDES, LUIS; OLIVEIRA-RIBEIRO, MARILIA; ZHANG, JIN; SALAMONSEN, LOIS. Endometrial chemokines, uterine natural killer cells and mast cells in long-term users of the levonorgestrel-releasing intrauterine system. Human Reproduction, v. 21, n. 5, p. 1129-1134, May 2006. (03/08391-7)

SANCHES, LUCIANA; MARCHI, NADIA M.; CASTRO, SARA; JULIATO, CASSIA TEATIN; VILLARROEL, MARINA; BAHAMONDES, LUIS. Forearm bone mineral density in postmenopausal former users of depot medroxyprogesterone acetate. Contraception, v. 78, n. 5, p. 365-369, NOV 2008. (03/08391-7)

OLIVEIRA-RIBEIRO‚ M.; PETTA‚ C.A.; DE ANGELO ANDRADE‚ L.A.L.; HIDALGO‚ M.M.; PELLOGIA‚ A.; BAHAMONDES‚ L.. Endometrial histology‚ microvascular density and caliber‚ and matrix metalloproteinase-3 in users of the Nestorone®-releasing contraceptive implant with and without endometrial breakthrough bleeding. Contraception, v. 73, n. 6, p. 634-640, 2006. (03/08391-7)

BAHAMONDES‚ L.; PETTA‚ C.A.; FERNANDES‚ A.; MONTEIRO‚ I.. Use of the levonorgestrel-releasing intrauterine system in women with endometriosis‚ chronic pelvic pain and dysmenorrhea. Contraception, v. 75, n. 6, p. S134-S139, 2007. (03/08391-7)

BRAGHETO‚ A.M.; CASERTA‚ N.; BAHAMONDES‚ L.; PETTA‚ C.A.. Effectiveness of the levonorgestrel-releasing intrauterine system in the treatment of adenomyosis diagnosed and monitored by magnetic resonance imaging. Contraception, v. 76, n. 3, p. 195-199, 2007. (03/08391-7)

NASCIMENTO, JOSIANE A. A. DO; SEPPALA, MARKKU; PERDIGÃO, ANTERO; ESPEJO-ARCE, XIMENA; MUNUCE, MARIA JOSÉ; HAUTALA, LAURA; KOISTINEN, RIITTA; ANDRADE, LILIANA; BAHAMONDES, LUÍS. In vivo assessment of the human sperm acrosome reaction and the expression of glycodelin-A in human endometrium after levonorgestrel-emergency contraceptive pill administration. Human Reproduction, v. 22, n. 8, p. 2190-2195, Aug. 2007. (03/08391-7)

BAHAMONDES, LUIS; MONTEIRO-DANTAS, CECILIA; ESPEJO-ARCE, XIMENA; FERNANDES, ARLETE M. DOS SANTOS; LUI-FILHO, JEFFREY F.; PERROTTI, MARCOS; PETTA, CARLOS A.. A prospective study of the forearm bone density of users of etonorgestrel- and levonorgestrel-releasing contraceptive implants. Human Reproduction, v. 21, n. 2, p. 466-470, Feb. 2006. (03/08391-7)

BAHAMONDES, LUIS; ESPEJO-ARCE, XIMENA; HIDALGO, MARIA M.; HIDALGO-REGINA, CREUSA; TEATIN-JULIATO, CÁSSIA; PETTA, CARLOS A.. A cross-sectional study of the forearm bone density of long-term users of levonorgestrel-releasing intrauterine system. Human Reproduction, v. 21, n. 5, p. 1316-1319, May 2006. (03/08391-7)