Integrated impact of time-restricted eating and physical exercise on metabolic regulation and obesity-related disorders

• Grant number: 24/16630-8
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2025
• End date: June 30, 2028
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: José Rodrigo Pauli
• Grantee: José Rodrigo Pauli
• Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
• Associated researchers: Adelino Sanchez Ramos da Silva ; Dennys Esper Corrêa Cintra ; Eduardo Rochete Ropelle

Abstract

Steatotic liver disease associated with metabolic dysfunction (DHEADM) is characterized by the accumulation of fat in the liver, with a close relationship with metabolic and cardiovascular disorders. It is currently the most common liver disease in the world, affecting around 25% to 30% of the population. The etiophysiology of DHEADM is complex, with obesity being a highly relevant risk factor and, consequently, reducing body adiposity can mitigate the negative health outcomes related to this disease. The adoption of food restriction time (TRA) has been able to treat obesity and reduce the accumulation of fat in the body. However, there are several gaps to be explored. Above all, the effects of TRA combined with different types of physical exercise. Likewise, it is necessary to investigate whether there are other responses to TRA combined with physical exercise among men and women. Another very relevant question is whether knowing whether there are different responses to these interventions in ovariectomized female rodents. These trials will reveal the combined effects of TRA with physical exercise in the treatment of obesity, DHEADM, and its complications, to allow in the future for more personalized action in the fight against these diseases with a high prevalence in the population. Finally, the impacts of stopping these treatments will be explored, allowing us to understand the adaptations in the body, to create strategies to prevent weight regain and, therefore, metabolic disorders that increase cardiometabolic risk. (AU)