Biological evaluation of novel high entropy alloys with biofunctional surfaces for use as biomedical implants

• Grant number: 25/02860-4
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2025
• End date: June 30, 2026
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Physical Metallurgy
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Diego Rafael Nespeque Correa
• Grantee: Diego Rafael Nespeque Correa
• Principal researcher abroad: Peng Chen
• Institution abroad: Tohoku University, Japan
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
• Associated research grant: 24/03148-3 - Biofunctionalization of biomedical Ti-based alloys using micro-arc oxidation and the concept of high entropy oxides, AP.R

Abstract

High-entropy alloys (HEAs) are emerging solid solutions composed of five or more elements, being recognized for their unique engineering properties attributed to high configurational entropy and other factors, making them attractive for biomedical applications. Micro-arc oxidation is a versatile, low-cost technique used to coat Ti surfaces with a porous and thick oxide, which is powerful for corrosion-resistant dental and orthopedic implants and other specific medical applications. Micro-arc oxidation in bioactive-rich electrolytes plays a crucial role in implant integration and stability by depositing vital minerals like Ca, P, and Mg on the implant surface, enhancing biocompatibility and promoting tissue regeneration, thereby ensuring strong bonding with adjacent bone tissues. However, the cells and bacteria interaction with the porous MAO coatings deserves further testing to better evaluate the application as implants. Given that, this project aims to perform biological testing in recently developed HEAs after MAO treatment, considering the surface interaction with cells and bacteria. The prospect is that the acquired results open new prospects for the use of HEAs as biomedical implants. (AU)