Development of novel high entropua alloys based on low cost alloying elements for biomedical applications

• Grant number: 25/19638-2
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2026
• End date: December 31, 2026
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Physical Metallurgy
• Principal Investigator: Diego Rafael Nespeque Correa
• Grantee: Diego Rafael Nespeque Correa
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
• City of the host institution: Bauru
• Associated research grant: 24/03148-3 - Biofunctionalization of biomedical Ti-based alloys using micro-arc oxidation and the concept of high entropy oxides, AP.R

Abstract

High entropy alloys have stood out in recent years due to their exceptional properties, stemming from their multicomponent composition. Recently, high entropy alloys have been considered for use as biomaterials; however, the alloying elements must be selected to meet the needs of the human body. In this context, the equiatomic alloy TiNbZrTaMo was initially proposed as an alternative for use as implants; however, the presence of refractory metals ultimately raises the melting point and consequently increases the processing cost of the alloy. This project aims to develop new high entropy alloys for use as biomaterials, by replacing refractory metals with non-toxic alloying elements that have a low melting point. After defining the proportion of alloying elements by theoretical design (CALPHAD), the sample will be produced by electric arc melting and subjected to X-ray diffraction (XRD), optical microscopy (OM), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), Vickers microhardness, modulus of elasticity, electrochemical tests (corrosion), and cytotoxicity. With this, it is expected to obtain a new low-cost high-entropy alloy for use in biomedical implants and external prosthetics. (AU)