Neural bases for motivated behavior

• Grant number: 05/59286-4
• Support Opportunities: Research Projects - Thematic Grants
• Start date: June 01, 2006
• End date: May 31, 2011
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Newton Sabino Canteras
• Grantee: Newton Sabino Canteras
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Carol Fuzeti Elias

Abstract

Motivated behaviors are those fundamental for survival of the individual or the species, and therefore accompanied by a high degree of motivation, such as, the behaviors of nutrition, reproduction and defense. Giving continuity to our studies on the neural organization of motivated behaviors, we are proposing in this theme a series of studies which aim to broaden our knowledge about the organization of defense behavior in the face of a natural predator, of the predatory hunt, of the intra-specific agonistic behavior, as well as an investigation of neurochemical and functional aspects linked to the pre-mammilar ventral nucleus, and integrative spot sensitive to the nutritional state of animals and which is involved in neuroendocrine responses and in the regulation of various reproductive behaviors, such as the behavior of mating and intra-specific agonistics. In the first three projects we will continue our studies on the neural bases of the defense responses. In the first project we propose to characterize the corticoamygdalar paths involved in the detection of predators. Thus, we propose a series of studies combining the use of functional mapping and tracking of neural paths with a view to identifying the corticoamygdalar paths potentially involved in the detection of predators. Subsequently, using selective lesions in these paths, we will examine the alterations in the behavioral responses during direct confrontation with the predator. In the second project we will evaluate the participation of thalamic goals (reuniens nucleus and ventral part of the anteromedial nucleus) and subthalamic (rostral part of unknown zone) of the hypothalamic defense circuit in the defense responses during direct confrontation with the predator (innate response), as well as in the exposure to environments where they were previously exposed to the predator (contextual response). The third project concerns an anatomical study where we will evaluate the projections of the dorsolateral of the periaqueductal grey matter and of the cuneiform nucleus, two fundamental locations for the organization of unconditioned and contextual responses linked to predatory threat. (AU)

Scientific publications

(18)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MOTA-ORTIZ, SANDRA REGINA; SUKIKARA, MARCIA HARUMI; FELICIO, LUCIANO FREITAS; CANTERAS, NEWTON SABINO. Afferent Connections to the Rostrolateral Part of the Periaqueductal Gray: A Critical Region Influencing the Motivation Drive to Hunt and Forage. NEURAL PLASTICITY, 2009. (05/59286-4)

CEZARIO, A. F.; RIBEIRO-BARBOSA, E. R.; BALDO, M. V. C.; CANTERAS, N. S.. Hypothalamic sites responding to predator threats - the role of the dorsal premammillary nucleus in unconditioned and conditioned antipredatory defensive behavior. European Journal of Neuroscience, v. 28, n. 5, p. 1003-1015, Sept. 2008. (05/59286-4)

SANTOS, LUCÉLIA M. DOS; FERRO, MARCELO M.; MOTA-ORTIZ, SANDRA R.; BALDO, MARCUS V.; CUNHA, CLÁUDIO DA; CANTERAS, NEWTON S.. Effects of ventrolateral striatal inactivation on predatory hunting. Physiology & Behavior, v. 90, n. 4, p. 669-673, Mar. 2007. (05/59286-4)

CARVALHO-NETTO, EDUARDO F.; MARTINEZ, RAQUEL C. R.; BALDO, MARCUS VINICIUS C.; CANTERAS, NEWTON SABINO. Evidence for the thalamic targets of the medial hypothalamic defensive system mediating emotional memory to predatory threats. NEUROBIOLOGY OF LEARNING AND MEMORY, v. 93, n. 4, p. 479-486, MAY 2010. (05/59286-4)

DO MONTE, FABRICIO H. M.; CANTERAS, NEWTON SABINO; FERNANDES, DANIEL; ASSREUY, JAMIL; CAROBREZ, ANTONIO P.. New Perspectives on beta-Adrenergic Mediation of Innate and Learned Fear Responses to Predator Odor. JOURNAL OF NEUROSCIENCE, v. 28, n. 49, p. 13296-13302, DEC 3 2008. (05/59286-4)

DOS SANTOS, LUCELIA MENDES; BOSCHEN, SUELEN LUCIO; BORTOLANZA, MARIZA; DE OLIVEIRA, WAGNER FERNANDES; FURIGO, ISADORA CLIVATTI; MOTA-ORTIZ, SANDRA REGINA; DA CUNHA, CLAUDIO; CANTERAS, NEWTON SABINO. The role of the ventrolateral caudoputamen in predatory hunting. Physiology & Behavior, v. 105, n. 3, p. 893-898, FEB 1 2012. (05/59286-4)

DONATO, JR., J.; LEE, C.; RATRA, D. V.; FRANCI, C. R.; CANTERAS, N. S.; ELIAS, C. F.. LESIONS OF THE VENTRAL PREMAMMILLARY NUCLEUS DISRUPT THE DYNAMIC CHANGES IN KISS1 AND GNRH EXPRESSION CHARACTERISTIC OF THE PROESTRUS-ESTRUS TRANSITION. Neuroscience, v. 241, p. 67-79, JUN 25 2013. (05/59286-4)

MOTA-ORTIZ, SANDRA REGINA; SUKIKARA, MARCIA HARUMI; FELICIO, LUCIANO FREITAS; CANTERAS, NEWTON SABINO. Afferent Connections to the Rostrolateral Part of the Periaqueductal Gray: A Critical Region Influencing the Motivation Drive to Hunt and Forage. NEURAL PLASTICITY, v. 2009, p. 11-pg., 2009-01-01. (05/59286-4)

MOTTA, SIMONE C.; GOTO, MARINA; GOUVEIA, FLAVIA V.; BALDO, MARCUS V. C.; CANTERAS, NEWTON S.; SWANSON, LARRY W.. Dissecting the brain's fear system reveals the hypothalamus is critical for responding in subordinate conspecific intruders. Proceedings of the National Academy of Sciences of the United States of America, v. 106, n. 12, p. 4870-4875, Mar. 2009. (05/59286-4)

CAVALCANTE, JUDNEY CLEY; BITTENCOURT, JACKSON CIONI; ELIAS, CAROL FUZETI. Distribution of the neuronal inputs to the ventral premammillary nucleus of male and female rats. Brain Research, v. 1582, p. 77-90, SEP 25 2014. (05/59286-4, 04/13849-5)

MOTTA, SIMONE C.; GUIMARAES, CIBELE CARLA; FURIGO, ISADORA CLIVATTI; SUKIKARA, MARCIA HARUMI; BALDO, MARCUS V. C.; LONSTEIN, JOSEPH S.; CANTERAS, NEWTON S.. Ventral premammillary nucleus as a critical sensory relay to the maternal aggression network. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 110, n. 35, p. 14438-14443, AUG 27 2013. (05/59286-4, 11/02425-3)

DONATO, JR., JOSE; SILVA, RENATA J.; SITA, LUCIANE V.; LEE, SYANN; LEE, CHARLOTTE; LACCHINI, SILVIA; BITTENCOURT, JACKSON C.; FRANCI, CELSO R.; CANTERAS, NEWTON S.; ELIAS, CAROL F.. The Ventral Premammillary Nucleus Links Fasting-Induced Changes in Leptin Levels and Coordinated Luteinizing Hormone Secretion. JOURNAL OF NEUROSCIENCE, v. 29, n. 16, p. 5240-5250, APR 22 2009. (04/13849-5, 05/59286-4, 04/09638-9)

FURIGO, I. C.; DE OLIVEIRA, W. F.; DE OLIVEIRA, A. R.; COMOLI, E.; BALDO, M. V. C.; MOTA-ORTIZ, S. R.; CANTERAS, N. S.. THE ROLE OF THE SUPERIOR COLLICULUS IN PREDATORY HUNTING. Neuroscience, v. 165, n. 1, p. 1-15, JAN 13 2010. (05/59286-4)

MARTINEZ, R. C.; CARVALHO-NETTO, E. F.; RIBEIRO-BARBOSA, E. R.; BALDO, M. V. C.; CANTERAS, N. S.. AMYGDALAR ROLES DURING EXPOSURE TO A LIVE PREDATOR AND TO A PREDATOR-ASSOCIATED CONTEXT. Neuroscience, v. 172, p. 314-328, JAN 13 2011. (05/59286-4)

MARTINEZ, RAQUEL C. R.; CARVALHO-NETTO, EDUARDO F.; AMARAL, VANESSA C. S.; NUNES-DE-SOUZA, RICARDO L.; CANTERAS, NEWTON S.. Investigation of the hypothalamic defensive system in the mouse. Behavioural Brain Research, v. 192, n. 2, p. 185-190, Oct. 2008. (05/59286-4)

CANTERAS, NEWTON S.; KROON, JULIANA A. V.; DO-MONTE, FABRÍCIO H. M.; PAVESI, ELOISA; CAROBREZ, ANTONIO P.. Sensing danger through the olfactory system: the role of the hypothalamic dorsal premammillary nucleus. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 32, n. 7, p. 1228-1235, Sept. 2008. (05/59286-4)

GROSS, CORNELIUS T.; CANTERAS, NEWTON SABINO. The many paths to fear. NATURE REVIEWS NEUROSCIENCE, v. 13, n. 9, p. 8-pg., 2012-09-01. (05/59286-4)

MOTTA, SIMONE C.; GOTO, MARINA; GOUVEIA, FLAVIA V.; BALDO, MARCUS V. C.; CANTERAS, NEWTON S.; SWANSON, LARRY W.. Dissecting the brain's fear system reveals the hypothalamus is critical for responding in subordinate conspecific intruders. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 106, n. 12, p. 6-pg., 2009-03-24. (05/59286-4)