Evaluation of the influence of environmental and chemical factors in parameters linked to the reproduction of mice

• Grant number: 96/04273-4
• Support Opportunities: Research Projects - Thematic Grants
• Start date: July 01, 1997
• End date: June 30, 2001
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Reproduction
• Principal Investigator: Maria Martha Bernardi
• Grantee: Maria Martha Bernardi
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant(s): 98/06255-9 - Perinatal treatment with picrotoxin induces sexual behavioral and neuroendocrine changes in male rats, AR.EXT

Abstract

The present project seeks to evaluate the influence of environmental and chemical factors on parameters associated with the reproduction of mice. To this end, 4 sub-projects form the basis of this request within our line of research into the toxicology of reproduction: 1) effect of post-natal exposure to astemizole in sexual parameters of the offspring of female mice; 2) effects of the perinatal exposure to picrotoxine in sexual parameters of the offspring of female mice: biochemical and behavioral evaluation; 3) effect of the exposure to phenvalerate in the ante- and postnatal period on the sexual differentiation of the brain in sexual parameters of the offspring of female mice; 4) effects of maternal postnatal exposure to lead in sexual parameters of the offspring of male mice. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BERNARDI, MARIA M.; KIRSTEN, THIAGO B.; TEODOROV, ELIZABETH; BASO, ANA C. Z.; PROSDOCIMI, FABIO C.; FELICIO, LUCIANO F.. Maternal exposure to picrotoxin modifies the response of the GABA(A) receptor during sexual behavior of adult male rat offspring. Behavioural Pharmacology, v. 23, n. 7, p. 703-709, OCT 2012. (96/04273-4)

TEODOROV‚ E.; HABR-ALENCAR‚ SF; SIDER‚ LH; FELICIO‚ LF; VAROLI‚ FMF; BERNARDI‚ MM. Prenatal treatment with picrotoxin promotes heterotypical sexual behavioral and neurochemical changes in male rat offspring. Brain Research, v. 1069, n. 1, p. 113-119, 2006. (96/04273-4)