Metabolism of phospholipids in schizophrenia and Alzheimer's disease

• Grant number: 97/11083-0
• Support type: Research Projects - Thematic Grants
• Duration: May 01, 1998 - April 30, 2002
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal researcher: Wagner Farid Gattaz
• Grantee: Wagner Farid Gattaz
• Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated grant(s): 00/09802-2 - Andrea Singer | Goethe University Frankfurt - Germany, AV.EXT; 00/06594-0 - Gunter Eckert | Goethe University Frankfurt - Germany, AV.EXT; 00/02240-9 - Beate Glaser | Children's Clinic Dahn - Germany, AV.EXT
• Associated scholarship(s): 00/10975-9 - Association between alleles of phospholipase A2 genes complex and Alzheimer's Disease, BP.IC; 00/08775-1 - Study of evoked and endogenous potentials obtained from electroencephalographic records of patients with Alzheimer's disease and schizophrenia, BP.PD; 00/05288-2 - Phospholipase A2 and its influence on the processing of memory in rats, BP.DR; 99/12360-2 - Association of phospholipase A2 complex genes and schizophrenia , BP.MS; 98/07640-3 - Phospholipid metabolism in Alzheimer's disease and schizophrenia (4): electrophysiology of the frontal cortex in schizophrenia and in Alzheimer's disease, BP.PD

Abstract

Disturbances in the metabolism of phospholipids were described by us and by other authors in schizophrenia and Alzheimer's disease. In this thematic project we will investigate the mechanisms which lead to these disturbances in both illnesses, their repercussions for brain function and their clinical implications. This investigation will be carried out in four inter-related dimensions: Biochemistry and Spectrography, Molecular Genetics, Molecular Biology and Electrophysiology. The laboratory findings will be juxtaposed to psychopathological, neuropsychological and evolutive parameters. (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FORLENZA‚ O.V.; WACKER‚ P.; NUNES‚ P.V.; YACUBIAN‚ J.; CASTRO‚ C.C.; OTADUY‚ M.C.G.; GATTAZ‚ W.F. Reduced phospholipid breakdown in Alzheimer’s brains: a 31 P spectroscopy study. Psychopharmacology, v. 180, n. 2, p. 359-365, 2005.

SCHAEFFER‚ E.L.; GATTAZ‚ W.F. Inhibition of calcium-independent phospholipase A 2 activity in rat hippocampus impairs acquisition of short-and long-term memory. Psychopharmacology, v. 181, n. 2, p. 392-400, 2005.

L.F.H. BASILE; J. YACUBIAN; B.L.C. FERREIRA; A.C. VALIM; W.F. GATTAZ. Topographic abnormality of slow cortical potentials in schizophrenia. Brazilian Journal of Medical and Biological Research, v. 37, n. 1, p. 97-109, Jan. 2004.

BASILE‚ L.F.H.; YACUBIAN‚ J.; DE CASTRO‚ C.C.; GATTAZ‚ W.F. Widespread electrical cortical dysfunction in schizophrenia. SCHIZOPHRENIA RESEARCH, v. 69, n. 2, p. 255-266, 2004.

JUNQUEIRA‚ R.; CORDEIRO‚ Q.; MEIRA-LIMA‚ I.; GATTAZ‚ W.F.; VALLADA‚ H. Allelic association analysis of phospholipase A2 genes with schizophrenia. PSYCHIATRIC GENETICS, v. 14, n. 3, p. 157-160, 2004.

TAVARES‚ H.; YACUBIAN‚ J.; TALIB‚ L.L.; BARBOSA‚ N.R.; GATTAZ‚ W.F. Increased phospholipase A2 activity in schizophrenia with absent response to niacin. SCHIZOPHRENIA RESEARCH, v. 61, n. 1, p. 1-6, 2003.

QUIRINO CORDEIRO JÚNIOR; RICARDO JUNQUEIRA; HOMERO VALLADA. Estudo de associação entre o polimorfismo serina-9-glicina do receptor dopaminérgico D3 e esquizofrenia. Arquivos de Neuro-Psiquiatria, v. 59, n. 2A, p. 219-222, Jun. 2001.

GATTAZ‚ W.F.; LARA‚ D.R.; ELKIS‚ H.; PORTELA‚ L.V.; GONÇALVES‚ C.A.; TORT‚ A.B.; HENNA‚ J.; SOUZA‚ D.O. Decreased S100-beta protein in schizophrenia: preliminary evidence. SCHIZOPHRENIA RESEARCH, v. 43, n. 2, p. 91-95, 2000.

LUIS FH BASILE. Alterações eletrofisiológicas na esquizofrenia. Revista Brasileira de Psiquiatria, v. 22, p. 12-14, Maio 2000.

WAGNER F GATTAZ. Neuroquímica da esquizofrenia: papel dos fosfolípides. Revista Brasileira de Psiquiatria, v. 22, p. 5-8, Maio 2000.

YACUBIAN‚ J.; DE CASTRO‚ C.C.; GONÇALES‚ L.; CERRI‚ G.G.; GATTAZ‚ W.F. Estabilidade intra-individual dos parâmetros obtidos pela espectroscopia de fósforo do encéfalo. ARCHIVES OF CLINICAL PSYCHIATRY, v. 26, p. 68-71, 1999.