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Phenotypic, genetic, immunological and neurobiological characterization of the obsessive compulsive disorder and its implications for treatment

Abstract

This thematic project involves a set of studies, which aim to test specific original hypotheses, using diverse methods. Its objective is to supply information concerning phenotypic (module I), genetic (module 11), immunological (module 111), neurobiological (module IV) and treatment (module V) aspects of obsessive-compulsive disorder (OCO). The execution of this project involves the creation of a research net, including the three largest Public Universities of the State of São Paulo (USP, UNESP and UNIFESP), emphasizing the training and upbringing of human resources (Post-doctoral, Ph.D., Master of Sciences and undergraduate students' scientific initiation) in the diverse Institutions involved. As a result of the collaboration, studies presented herein will count on larger clinical samples, gathered in a short period of time. Once accomplished, we will also consolidate our exchange with other remaining centers of the country (sponsored by CNPq), as well as collaborations with Harvard and Yale Universities, and a new partnership with the University of California. On the whole, all projects are anchored in a main project, composed of a follow-up longitudinal study of 240 patients who will receive systematic assessment and treatment for two years. The five linked modules are parts of this larger project. Module I is composed of ten projects on the phenotypic characterization of OCO, including diverse strategies that can heuristically contribute to the identification of etiologically involved genes (modules 11 and 111), to the discovery of neuroimaging (module IV) endophenotypes (measurable components which cannot be observed in a clinical assessment, halfway between the genotype and the final expression of the illness) and to the identification of predictive factors to treatment response (module V). Module 11 includes studies of epidemiologic, molecular and segregation analysis genetics, aiming to investigate family phenotypes, vulnerability genes and possible inheritance models of the disorder, respectively... (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Las múltiples caras de la obsesión 
The many faces of obsession 
Articles published in other media outlets (1 total):
UOL: Quando entrar setembro..... (05/Sep/2020)

Scientific publications (19)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VELLOSO, PATRICIA; PICCINATO, CINTHIA; FERRAO, YGOR; PERIN, EDUARDO ALIENDE; CESAR, RAONY; FONTENELLE, LEONARDO F.; HOUNIE, ANA G.; DO ROSARIO, MARIA CONCEICAO. Clinical predictors of quality of life in a large sample of adult obsessive-compulsive disorder outpatients. COMPREHENSIVE PSYCHIATRY, v. 86, p. 82-90, OCT 2018. Web of Science Citations: 1.
STARCEVIC, VLADAN; BERLE, DAVID; DO ROSARIO, MARIA CONCEICAO; BRAKOULIAS, VLASIOS; FERRAO, YGOR A.; VISWASAM, KIRUPAMANI; SHAVITT, ROSELI; MIGUEL, EURIPEDES; FONTENELLE, LEONARDO F. Use of benzodiazepines in obsessive-compulsive disorder. INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, v. 31, n. 1, p. 27-33, JAN 2016. Web of Science Citations: 4.
TORRES, ALBINA R.; FERRAO, YGOR. A.; SHAVITT, ROSELI G.; DINIZ, JULIANA B.; COSTA, DANIEL L. C.; DO ROSARIO, MARIA CONCEICAO; MIGUEL, EURIPEDES C.; FONTENELLE, LEONARDO F. Panic Disorder and Agoraphobia in OCD patients: Clinical profile and possible treatment implications. COMPREHENSIVE PSYCHIATRY, v. 55, n. 3, p. 588-597, APR 2014. Web of Science Citations: 7.
DE WIT, STELLA J.; ALONSO, PINO; SCHWEREN, LIZANNE; MATAIX-COLS, DAVID; LOCHNER, CHRISTINE; MENCHON, JOSE M.; STEIN, DAN J.; FOUCHE, JEAN-PAUL; SORIANO-MAS, CARIES; SATO, JOAO R.; HOEXTER, MARCELO Q.; DENYS, DAMIAAN; NAKAMAE, TAKASHI; NISHIDA, SEIJI; KWON, JUN SOO; JANG, JOON HWAN; BUSATTO, GERALDO F.; CARDONER, NARCIS; CATH, DANIELLE C.; FUKUI, KENJI; JUNG, WI HOON; KIM, SUNG NYUN; MIGUEL, EURIPIDES C.; NARUMOTO, JIN; PHILLIPS, MARY L.; PUJOL, JESUS; REMIJNSE, PETER L.; SAKAI, YUKI; SHIN, NA YOUNG; YAMADA, KEI; VELTMAN, DICK J.; VAN DEN HEUVEL, ODILE A. Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder. American Journal of Psychiatry, v. 171, n. 3, p. 340-349, MAR 2014. Web of Science Citations: 110.
HOEXTER, MARCELO Q.; MIGUEL, EURIPEDES C.; DINIZ, JULIANA B.; SHAVITT, ROSELI G.; BUSATTO, GERALDO F.; SATO, JOAO R. Predicting obsessive-compulsive disorder severity combining neuroimaging and machine learning methods. Journal of Affective Disorders, v. 150, n. 3, p. 1213-1216, SEP 25 2013. Web of Science Citations: 19.
KICHUK, STEPHEN A.; TORRES, ALBINA R.; FONTENELLE, LEONARDO F.; ROSARIO, MARIA CONCEICAO; SHAVITT, ROSELI G.; MIGUEL, EURIPEDES C.; PITTENGER, CHRISTOPHER; BLOCH, MICHAEL H. Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 44, p. 233-239, JUL 1 2013. Web of Science Citations: 18.
HOEXTER, MARCELO Q.; DOUGHERTY, DARIN D.; SHAVITT, ROSELI G.; D'ALCANTE, CARINA C.; DURAN, FABIO L. S.; LOPES, ANTONIO C.; DINIZ, JULIANA B.; BATISTUZZO, MARCELO C.; EVANS, KARLEYTON C.; BRESSAN, RODRIGO A.; BUSATTO, GERALDO F.; MIGUEL, EURIPEDES C. Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive-compulsive disorder. European Neuropsychopharmacology, v. 23, n. 7, p. 569-580, JUL 2013. Web of Science Citations: 29.
ALVARENGA, PEDRO G.; DO ROSARIO, MARIA C.; BATISTUZZO, MARCELO C.; DINIZ, JULIANA B.; SHAVITT, ROSELI G.; DURAN, FABIO L. S.; DOUGHERTY, DARIN D.; BRESSAN, RODRIGO A.; MIGUEL, EURIPEDES C.; HOEXTER, MARCELO Q. Obsessive-compulsive symptom dimensions correlate to specific gray matter volumes in treatment-naive patients. JOURNAL OF PSYCHIATRIC RESEARCH, v. 46, n. 12, p. 1635-1642, DEC 2012. Web of Science Citations: 33.
ROSA, ANA CAROLINA; DINIZ, JULIANA BELO; FOSSALUZA, VICTOR; TORRES, ALBINA RODRIGUES; FONTENELLE, LEONARDO FRANKLIN; DE MATHIS, ALICE SIMOES; ROSARIO, MARIA DA CONCEICAO; MIGUEL, EURIPEDES CONSTANTINO; SHAVITT, ROSELI GEDANKE. Clinical correlates of social adjustment in patients with obsessive-compulsive disorder. JOURNAL OF PSYCHIATRIC RESEARCH, v. 46, n. 10, p. 1286-1292, OCT 2012. Web of Science Citations: 24.
TORRES, ALBINA R.; FONTENELLE, LEONARDO F.; FERRAO, YGOR A.; DO ROSARIO, MARIA CONCEICAO; TORRESAN, RICARDO C.; MIGUEL, EURIPEDES C.; SHAVITT, ROSELI G. Clinical features of obsessive-compulsive disorder with hoarding symptoms: A multicenter study. JOURNAL OF PSYCHIATRIC RESEARCH, v. 46, n. 6, p. 724-732, JUN 2012. Web of Science Citations: 37.
FERRAO, YGOR ARZENO; SHAVITT, ROSELI GEDANKE; PRADO, HELENA; FONTENELLE, LEONARDO F.; MALAVAZZI, DANTE MARINO; DE MATHIS, MARIA ALICE; HOUNIE, ANA GABRIELA; MIGUEL, EURIPEDES CONSTANTINO; DO ROSARIO, MARIA CONCEICAO. Sensory phenomena associated with repetitive behaviors in obsessive-compulsive disorder: An exploratory study of 1001 patients. PSYCHIATRY RESEARCH, v. 197, n. 3, p. 253-258, MAY 30 2012. Web of Science Citations: 61.
CAPPI, CAROLINA; MUNIZ, RENAN KAWANO; SAMPAIO, ALINE SANTOS; CORDEIRO, QUIRINO; BRENTANI, HELENA; PALACIOS, SELMA A.; MARQUES, ANDREA H.; VALLADA, HOMERO; MIGUEL, EURIPEDES CONSTANTINO; GUILHERME, LUIZA; HOUNIE, ANA GABRIELA. Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder. Arquivos de Neuro-Psiquiatria, v. 70, n. 2, p. 87-90, FEB 2012. Web of Science Citations: 10.
TORRES, ALBINA R.; RAMOS-CERQUEIRA, ANA TERESA A.; FERRAO, YGOR A.; FONTENELLE, LEONARDO F.; DO ROSARIO, MARIA CONCEICAO; MIGUEL, EURIPEDES C. Suicidality in Obsessive-Compulsive Disorder: Prevalence and Relation to Symptom Dimensions and Comorbid Conditions. JOURNAL OF CLINICAL PSYCHIATRY, v. 72, n. 1, p. 17-26, JAN 2011. Web of Science Citations: 59.
HOEXTER, MARCELO QUEIROZ; DE SOUZA DURAN, FABIO LUIS; D'ALCANTE, CARINA CHAUBET; DOUGHERTY, DARIN DEAN; SHAVITT, ROSELI GEDANKE; LOPES, ANTONIO CARLOS; DINIZ, JULIANA BELO; DECKERSBACH, THILO; BATISTUZZO, MARCELO CAMARGO; BRESSAN, RODRIGO AFFONSECA; MIGUEL, EURIPEDES CONSTANTINO; BUSATTO, GERALDO FILHO. Gray Matter Volumes in Obsessive-Compulsive Disorder Before and After Fluoxetine or Cognitive-Behavior Therapy: A Randomized Clinical Trial. NEUROPSYCHOPHARMACOLOGY, v. 37, n. 3, p. 734-745, 2011. Web of Science Citations: 67.
QUIRINO CORDEIRO; CAROLINA CAPPI; ALINE SANTOS SAMPAIO; SELMA ALIOTTI PALÁCIOS; CARLOS ALBERTO DE BRAGANÇA PEREIRA; ROSELI GEDANKE SHAVITT; EURÍPEDES CONSTANTINO MIGUEL; LUIZA GUILHERME; ANA GABRIELA HOUNIE. Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder. Revista Brasileira de Psiquiatria, v. 31, n. 2, p. -, Jun. 2009.
SAMPAIO, ALINE S.; MIGUEL, EURIPEDES C.; BORCATO, SONIA; BATISTUZZO, MARCELO; FOSSALUZA, VICTOR; GELLER, DANIEL A.; HOUNIE, ANA G. Perinatal risk factors and obsessive-compulsive spectrum disorders in patients with rheumatic fever. GENERAL HOSPITAL PSYCHIATRY, v. 31, n. 3, p. 288-291, MAY-JUN 2009. Web of Science Citations: 4.
TORRESAN, RICARDO CEZAR; DE ABREU RAMOS-CERQUEIRA, ANA TERESA; DE MATHIS, MARIA ALICE; DINIZ, JULIANA BELO; FERRAO, YGOR ARZENO; MIGUEL, EURIPEDES CONSTANTINO; TORRES, ALBINA RODRIGUES. Sex differences in the phenotypic expression of obsessive-compulsive disorder: an exploratory study from Brazil. COMPREHENSIVE PSYCHIATRY, v. 50, n. 1, p. 63-69, JAN-FEB 2009. Web of Science Citations: 33.
LEE, JENNIFER C.; PRADO, HELENA S.; DINIZ, JULIANA B.; BORCATO, SONIA; DA SILVA, CRISTINA BELOTTO; HOUNIE, ANA G.; MIGUEL, EURIPEDES C.; LECKMAN, JAMES F.; DO ROSARIO, MARIA C. Perfectionism and sensory phenomena: phenotypic components of obsessive-compulsive disorder. COMPREHENSIVE PSYCHIATRY, v. 50, n. 5, p. 431-436, 2009. Web of Science Citations: 28.
HOUNIE, ANA GABRIELA; CAPPI, CAROLINA; CORDEIRO, QUIRINO; SAMPAIO, ALINE SANTOS; MORAES, IVANIL; DO ROSARIO, MARIA CONCEICAO; PALACIOS, SELMA A.; GOLDBERG, ANNA CARLA; VALLADA, HOMERO PINTO; MACHADO-LIMA, ARIANE; NAKANO, EDUARDO; KALIL, JORGE; PAULS, DAVID; PEREIRA, CARLOS ALBERTO B.; GUILHERME, LUIZA; MIGUEL, EURIPEDES CONSTANTINO. TNF-alpha polymorphisms are associated with obsessive-compulsive disorder. Neuroscience Letters, v. 442, n. 2, p. 86-90, SEP 12 2008. Web of Science Citations: 33.

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