Temporal lobe epilepsy: a study correlating brain image, morphological features, electrophysiological findings, hormonal and neurochemical aspects in humans with and without mesial temporal sclerosis

• Grant number: 05/56661-9
• Support Opportunities: Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants
• Start date: April 01, 2007
• End date: May 31, 2013
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Luiz Eugenio Araujo de Moraes Mello
• Grantee: Luiz Eugenio Araujo de Moraes Mello
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Principal investigators: Debora Amado Scerni ; Maria da Graca Naffah Mazzacoratti ; Maria José da Silva Fernandes
• Associated scholarship(s): 09/07558-1 - Hormonal effects on signal transduction and angiogenesis in the neocortex and hippocampus in women with medial sclerosis epilepsy in the reproductive period, BP.PD; 07/06550-1 - Purinoceptors expression in the hippocampal formation of patient with Temporal Lobe Epilepsy, BP.IC

Abstract

We aim at investigating different aspects of the epilepsies in humans ranging from electrophysiological and immunocitochemical investigations of surgically ressected tissue to the evalution of new therapeutic strategies to be used in the prophylaxis of post-lesional epilepsies. The proposed experiments will rely on magnetic resonance imaging and thus will attempt to provide correlations between the various different techniques. As probably the strongest Brazilian group doing electrophysiology and immunohistochemical evaluation of tissue sample form epilepsy patients we expect to provide an important support for other groups in the Cinapce program in our main areas of expertise. Given the foressen network activities envisioned by the Cinapce program we expect to be a major contributor of the program. (AU)