Neurobiology of fear and stress

• Grant number: 98/11187-2
• Support Opportunities: Research Projects - Thematic Grants
• Start date: April 01, 1999
• End date: March 31, 2003
• Field of knowledge: Biological Sciences - Pharmacology - Neuropsychopharmacology
• Principal Investigator: Marcus Lira Brandão
• Grantee: Marcus Lira Brandão
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Pesquisadores principais: Silvio Morato de Carvalho

Abstract

This project aims to advance current knowledge on the principles that govern the processing of sensory information and behavioral expression, as well as the electro-physiological and neurochemical mechanisms underlying adverse responses associated with fear and anxiety. The studies are arranged in seven large groups representing the behavioral (neurochemical modulation and environmental determination), sensory (analgesia induced by stress), electro-physiological, neuroimmunohistochemical and neurochemical correlatives of the defense reaction. In this last project efforts will also be made aimed at developing compounds with ansiolytic potential. (AU)

Scientific publications

(35)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

M.R. LAMPREA; F.P. CARDENAS; R. SILVEIRA; T.J. WALSH; S. MORATO. Effects of septal cholinergic lesion on rat exploratory behavior in an open-field. Brazilian Journal of Medical and Biological Research, v. 36, n. 2, p. 233-238, 2003-02-00. (98/11187-2)

CUADRA‚ G.; ZURITA‚ A.; MACEDO‚ C.E.; MOLINA‚ V.A.; BRANDÃO‚ M.L.. Electrical stimulation of the midbrain tectum enhances dopamine release in the frontal cortex. Brain Research Bulletin, v. 52, n. 5, p. 413-418, 2000. (98/11187-2)

BRANDÃO‚ M.L.; COIMBRA‚ N.C.; OSAKI‚ M.Y.. Changes in the auditory-evoked potentials induced by fear-evoking stimulations. Physiology & Behavior, v. 72, n. 3, p. 365-372, 2001. (98/11187-2)

NOBRE‚ M.J.; BORELLI‚ K.G.; BRANDÃO‚ M.L.. Fast-acting excitatory amino acids are involved in the enhancement of the aversiveness of the electrical stimulation of the inferior colliculus by systemic injections of muscimol. Life Sciences, v. 71, n. 25, p. 2961-2972, 2002. (02/03705-0, 98/11187-2)

MACEDO‚ C.E.; CASTILHO‚ V.M.; DE SOUZA E SILVA‚ M.A.; BRANDÃO‚ M.L.. Dual 5-HT mechanisms in basolateral and central nuclei of amygdala in the regulation of the defensive behavior induced by electrical stimulation of the inferior colliculus. Brain Research Bulletin, v. 59, n. 3, p. 189-195, 2002. (02/03705-0, 98/11187-2)

CASTILHO‚ V.; MACEDO‚ C.; BRANDÃO‚ M.. Role of benzodiazepine and serotonergic mechanisms in conditioned freezing and antinociception using electrical stimulation of the dorsal periaqueductal gray as unconditioned stimulus in rats. Psychopharmacology, v. 165, n. 1, p. 77-85, 2002. (02/03705-0, 98/11187-2)

MARTÍNEZ‚ J.C.; CARDENAS‚ F.; LAMPREA‚ M.; MORATO‚ S.. The role of vision and proprioception in the aversion of rats to the open arms of an elevated plus-maze. Behavioural Processes, v. 60, n. 1, p. 15-26, 2002. (98/11187-2)

CARDENAS‚ F.; LAMPREA‚ M.R.; MORATO‚ S.. Vibrissal sense is not the main sensory modality in rat exploratory behavior in the elevated plus-maze. Behavioural Brain Research, v. 122, n. 2, p. 169-174, 2001. (98/11187-2)

OLIVEIRA‚ L.C.; NOBRE‚ M.J.; BRANDÃO‚ M.L.; LANDEIRA-FERNANDEZ‚ J.. Role of amygdala in conditioned and unconditioned fear generated in the periaqueductal gray. Neuroreport, v. 15, n. 14, p. 2281, 2004. (98/11187-2)

CASTILHO‚ VM; BRANDÃO‚ ML. Conditioned antinociception and freezing using electrical stimulation of the dorsal periaqueductal gray or inferior colliculus as unconditioned stimulus are differentially regulated by 5-HT2A receptors in rats. Psychopharmacology, v. 155, n. 2, p. 154-162, 2001. (98/11187-2)

DE ARAÚJO‚ J.E.; HUSTON‚ J.P.; BRANDÃO‚ M.L.. Place aversion induced by microinjections of C-fragment of substance P into the dorsal periaqueductal gray of rats is mediated by tachykinin NK₁ receptors. Peptides, v. 22, n. 9, p. 1447-1452, 2001. (98/11187-2)

AVANZI‚ V.; BRANDÃO‚ ML. Activation of somatodendritic 5-HT1A autoreceptors in the median raphe nucleus disrupts the contextual conditioning in rats. Behavioural Brain Research, v. 126, n. 1-2, p. 175-184, 2001. (98/11187-2)

BOTELHO‚ S.; ESTANISLAU‚ C.; MORATO‚ S.. Effects of under-and overcrowding on exploratory behavior in the elevated plus-maze. Behavioural Processes, v. 74, n. 3, p. 357-362, 2007. (98/11187-2)

DE LUCA-VINHAS‚ M.C.Z.; MACEDO‚ C.E.; BRANDÃO‚ M.L.. Pharmacological assessment of the freezing‚ antinociception‚ and exploratory behavior organized in the ventrolateral periaqueductal gray. Pain, v. 121, n. 1-2, p. 94-104, 2006. (98/11187-2)

OSAKI, M. Y.; CASTELLAN-BALDAN, L.; CALVO, F.; CARVALHO, A. D.; FELIPPOTTI, T. T.; OLIVEIRA, R. DE; UBIALI, W. A.; PASCHOALIN-MAURIN, T.; ELIAS-FILHO, D. H.; MOTTA, V.; et al. Neuroanatomical and neuropharmacological study of opioid pathways in the mesencephalic tectum: effect of mu(1)- and kappa-opioid receptor blockade on escape behavior induced by electrical stimulation of the inferior colliculus. Brain Research, v. 992, n. 2, p. 179-192, Dec. 2003. (98/11187-2, 02/03705-0)

RODRIGUEZ LAMPREA, MARISOL; BECERRA GARCIA, ANDREA MILENA; MORATO, SILVIO. Effects of reversible inactivation of the medial septum on rat exploratory behavior in the elevated plus-maze using a test-retest paradigm. Behavioural Brain Research, v. 210, n. 1, p. 67-73, JUN 26 2010. (98/11187-2)

LAMPREA‚ M.R.; CARDENAS‚ F.P.; VIANNA‚ D.M.; CASTILHO‚ V.M.; CRUZ-MORALES‚ S.E.; BRANDÃO‚ M.L.. The distribution of fos immunoreactivity in rat brain following freezing and escape responses elicited by electrical stimulation of the inferior colliculus. Brain Research, v. 950, n. 1, p. 186-194, 2002. (02/03705-0, 98/11187-2)

SANTE‚ AB; NOBRE‚ MJ; BRANDAO‚ ML. Place aversion induced by blockade of [mu] or activation of [kappa] opioid receptors in the dorsal periaqueductal gray matter. Behavioural Pharmacology, v. 11, n. 7-8, p. 583-589, 2000. (98/11187-2)

D.M.L. VIANNA; M.L. BRANDÃO. Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fear. Brazilian Journal of Medical and Biological Research, v. 36, n. 5, p. 557-566, 2003-05-00. (98/11187-2)

DOMINGUEZ‚ R.; CRUZ-MORALES‚ S.E.; CARVALHO‚ M.C.; XAVIER‚ M.; BRANDAO‚ M.L.. Effect of steroid injection to newborn rats on serotonin activity in frontal cortex and raphe. Neuroreport, v. 14, n. 4, p. 597-599, 2003. (98/11187-2)

DE ARAUJO‚ JE; HASENÖHRL‚ RU; HUSTON‚ JP; BRANDÃO‚ ML. Hyperanxiety produced by periaqueductal gray injection of chondroitin sulphate glycosaminoglycan. Neuroreport, v. 12, n. 14, p. 3081-3084, 2001. (98/11187-2)

LAMPREA‚ MR; CARDENAS‚ FP; SILVEIRA‚ R.; MORATO‚ S.; WALSH‚ TJ. Dissociation of memory and anxiety in a repeated elevated plus maze paradigm: forebrain cholinergic mechanisms. Behavioural Brain Research, v. 117, n. 1, p. 97-105, 2000. (98/11187-2)

SANTOS‚ NR; HUSTON‚ JP; BRANDAO‚ ML. Further evidence for the involvement of histamine H2 receptors in the control of defensive behaviour generated in the midbrain tectum. Behavioural Pharmacology, v. 13, n. 1, p. 73-80, 2002. (98/11187-2)

PANDOSSIO‚ JE; MOLINA‚ VA; BRANDAO‚ ML. Prior electrical stimulation of the inferior colliculus sensitizes rats to the stress of the elevated plus-maze test. Behavioural Brain Research, v. 109, n. 1, p. 19-25, 2000. (98/11187-2)

TRONCOSO‚ A.C.; OSAKI‚ M.Y.; MASON‚ S.; BORELLI‚ K.G.; BRANDÃO‚ M.L.. Apomorphine enhances conditioned responses induced by aversive stimulation of the inferior colliculus. NEUROPSYCHOPHARMACOLOGY, v. 28, n. 2, p. 284-291, 2003. (98/11187-2)

AVANZI‚ V.; SILVA‚ RCB; MACEDO‚ CE; BRANDÃO‚ ML. 5-HT mechanisms of median raphe nucleus in the conditioned freezing caused by light/foot-shock association. Physiology & Behavior, v. 78, n. 3, p. 471-477, 2003. (02/03705-0, 98/11187-2)

SILVA‚ RCB; SANTOS‚ NR; BRANDAO‚ ML. Influence of housing conditions on the effects of serotonergic drugs on feeding behavior in non-deprived rats. NEUROPSYCHOBIOLOGY, v. 47, n. 2, p. 98-101, 2003. (98/11187-2)

VIANNA‚ D.M.L.; GRAEFF‚ F.G.; LANDEIRA-FERNANDEZ‚ J.; BRANDÃO‚ M.L.. Lesion of the ventral periaqueductal gray reduces conditioned fear but does not change freezing induced by stimulation of the dorsal periaqueductal gray. LEARNING & MEMORY, v. 8, n. 3, p. 164-169, 2001. (98/11187-2)

SANTOS‚ NR; HUSTON‚ JP; BRANDÃO‚ ML. Escape behavior under tonic inhibitory control of histamine H2-receptor mediated mechanisms in the midbrain tectum. Behavioural Brain Research, v. 124, n. 2, p. 167-175, 2001. (98/11187-2)

ANSELONI‚ V.C.Z.; COIMBRA‚ N.C.; MORATO‚ S.; BRANDÃO‚ M.L.. A comparative study of the effects of morphine in the dorsal periaqueductal gray and nucleus accumbens of rats submitted to the elevated plus-maze test. Experimental Brain Research, v. 129, n. 2, p. 260-268, 1999. (98/11187-2)

NOBRE‚ M.J.; BRANDÃO‚ M.L.. Analysis of freezing behavior and ultrasonic vocalization in response to foot-shocks‚ ultrasound signals and GABAergic inhibition in the inferior colliculus: effects of muscimol and midazolam. European Neuropsychopharmacology, v. 14, n. 1, p. 45-52, 2004. (98/11187-2)

EICHENBERGER‚ GCD; RIBEIRO‚ SJ; OSAKI‚ MY; MARUOKA‚ RY; RESENDE‚ GCC; CASTELLAN-BALDAN‚ L.; CORRÍA‚ SAL; DA SILVA‚ LA; COIMBRA‚ NC. Neuroanatomical and psychopharmacological evidence for interaction between opioid and GABAergic neural pathways in the modulation of fear and defense elicited by electrical and chemical stimulation of the deep layers of the superior colliculus and dorsal periaqueductal gray matter. Neuropharmacology, v. 42, n. 1, p. 48-59, 2002. (98/11187-2)

DOMÍNGUEZ‚ R.; CRUZ-MORALES‚ S.E.; CARVALHO‚ M.C.; XAVIER‚ M.; BRANDAO‚ M.L.. Sex differences in serotonergic activity in dorsal and median raphe nucleus. Physiology & Behavior, v. 80, n. 2, p. 203-210, 2003. (98/11187-2)

DE ARAÚJO‚ J.E.; SILVA‚ R.C.B.; HUSTON‚ J.P.; BRANDÃO‚ M.L.. Anxiogenic effects of substance P and its 7-11 C terminal‚ but not the 1-7 N terminal‚ injected into the dorsal periaqueductal gray☆. Peptides, v. 20, n. 12, p. 1437-1443, 1999. (98/11187-2)

COIMBRA‚ NC; DE OLIVEIRA‚ R.; FREITAS‚ RL; RIBEIRO‚ SJ; BORELLI‚ KG; PACAGNELLA‚ RC; MOREIRA‚ JE; DA SILVA‚ LA; MELO‚ LL; LUNARDI‚ LO; et al. Neuroanatomical approaches of the tectum-reticular pathways and immunohistochemical evidence for serotonin-positive perikarya on neuronal substrates of the superior colliculus and periaqueductal gray matter involved in the elaboration of the defensive behavior and fear-induced analgesia. Experimental Neurology, v. 197, n. 1, p. 93-112, 2006. (98/11187-2, 02/03705-0)