| Grant number: | 04/12054-9 |
| Support Opportunities: | Research Projects - Thematic Grants |
| Start date: | January 01, 2005 |
| End date: | June 30, 2010 |
| Field of knowledge: | Biological Sciences - Genetics - Human and Medical Genetics |
| Principal Investigator: | Eloiza Helena Tajara da Silva |
| Grantee: | Eloiza Helena Tajara da Silva |
| Host Institution: | Faculdade de Medicina de São José do Rio Preto (FAMERP). São José do Rio Preto , SP, Brazil |
| City of the host institution: | São José do Rio Preto |
| Principal investigators | Victor Wünsch Filho |
Abstract
Head and neck squalors cell carcinoma is one of the most frequent neoplasias in Brazil. Patients in early stages frequently exhibit few symptoms, resulting in diagnosis delay and decrease in survival. Also, clinically and histological similar lesions can follow significantly different clinical courses show different responses to therapy. Unfortunately, despite intense research and improvements in detection and therapeutic strategies, the prediction of tumor behavior in this group of neoplasias is still limited and the 5-year survival rate remains low. The present study aims to investigate molecular markers of tumor aggressiveness in head and neck carcinomas that may be relevant for prognosis and therapeutic strategies. Specific aims include: 1) combining genomic and proteomic techniques, to investigate differences in gene and protein expression profiles from head and neck carcinomas and apparently normal counterparts. 2) their relations to clinical and laboratory parameters (disease stages or evolution); 3) to investigate genetic polimorphisms associated with metabolic pathways which are involved in tumor progression; 4) to validate emerging molecular markers by quantitative PCR, immunohistochemistry and genotyping in a large number of specimens. To achieve these aims, samples collected by the team of the Clinical genome project will be analyzed. This series includes 295 clinically well-characterized tumor samples, 239 surgical margins, and also blood samples from 460 patients and 345 controls. The data may elucidate the mechanisms governing genetic changes during tumor progression; and their relation to the tissue genetic background, resulting in new insights into signaling and metabolic pathway abnormalities that could be useful therapeutic targets. (AU)
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