Markers of aggressive behavior in head and neck tumors

• Grant number: 04/12054-9
• Support Opportunities: Research Projects - Thematic Grants
• Start date: January 01, 2005
• End date: June 30, 2010
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: Eloiza Helena Tajara da Silva
• Grantee: Eloiza Helena Tajara da Silva
• Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). São José do Rio Preto , SP, Brazil
• City of the host institution: São José do Rio Preto
• Principal investigators: Victor Wünsch Filho

Abstract

Head and neck squalors cell carcinoma is one of the most frequent neoplasias in Brazil. Patients in early stages frequently exhibit few symptoms, resulting in diagnosis delay and decrease in survival. Also, clinically and histological similar lesions can follow significantly different clinical courses show different responses to therapy. Unfortunately, despite intense research and improvements in detection and therapeutic strategies, the prediction of tumor behavior in this group of neoplasias is still limited and the 5-year survival rate remains low. The present study aims to investigate molecular markers of tumor aggressiveness in head and neck carcinomas that may be relevant for prognosis and therapeutic strategies. Specific aims include: 1) combining genomic and proteomic techniques, to investigate differences in gene and protein expression profiles from head and neck carcinomas and apparently normal counterparts. 2) their relations to clinical and laboratory parameters (disease stages or evolution); 3) to investigate genetic polimorphisms associated with metabolic pathways which are involved in tumor progression; 4) to validate emerging molecular markers by quantitative PCR, immunohistochemistry and genotyping in a large number of specimens. To achieve these aims, samples collected by the team of the Clinical genome project will be analyzed. This series includes 295 clinically well-characterized tumor samples, 239 surgical margins, and also blood samples from 460 patients and 345 controls. The data may elucidate the mechanisms governing genetic changes during tumor progression; and their relation to the tissue genetic background, resulting in new insights into signaling and metabolic pathway abnormalities that could be useful therapeutic targets. (AU)

Scientific publications

(36)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RAQUEL AJUB MOYSES; ROSSANA VERÓNICA MENDOZA LÓPEZ; PATRÍCIA MALUF CURY; SHEILA APARECIDA COELHO SIQUEIRA; OTÁVIO ALBERTO CURIONI; JOSÉ FRANCISCO DE GOIS FILHO; DAVID LIVINGSTONE ALVES FIGUEIREDO; ELOIZA HELENA TAJARA; PEDRO MICHALUART JR. Significant differe nces in demographic, clinical, and pathological features in relation to smoking and alcohol consumption among 1,633 head and neck cancer patients. Clinics, v. 68, n. 6, p. 738-744, 2013-06-00. (04/12054-9)

ANANTHARAMAN, DEVASENA; ABEDI-ARDEKANI, BEHNOUSH; BEACHLER, DANIEL C.; GHEIT, TARIK; OLSHAN, ANDREW F.; WISNIEWSKI, KATHY; WUNSCH-FILHO, VICTOR; TOPORCOV, TATIANA N.; TAJARA, ELOIZA H.; LEVI, JOSE EDUARDO; et al. Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer. International Journal of Cancer, v. 140, n. 9, p. 1968-1975, MAY 1 2017. (10/51168-0, 04/12054-9)

DE CARVALHO-NETO, PAULO BENTES; DOS SANTOS, MARCELO; DE CARVALHO, MARCOS BRASILINO; DA CUNHA MERCANTE, ANA MARIA; PINA DOS SANTOS, VIVIANE PRISCILA; SEVERINO, PATRICIA; TAJARA, ELOIZA HELENA; LOURO, IURI DRUMOND; ALVARES DA SILVA-CONFORTI, ADRIANA MADEIRA. FAS/FASL Expression Profile as a Prognostic Marker in Squamous Cell Carcinoma of the Oral Cavity. PLoS One, v. 8, n. 7, JUL 19 2013. (04/12054-9)

BOING, A. F.; FERREIRA ANTUNES, J. L.; BRASILINO DE CARVALHO, M.; FRANCISCO DE GOIS FILHO, J.; KOWALSKI, L. P.; MICHALUART, JR., P.; ELUF-NETO, J.; BOFFETTA, P.; WUENSCH-FILHO, V.; GENCAPO, HEAD NECK GENOME PROJECT. How much do smoking and alcohol consumption explain socioeconomic inequalities in head and neck cancer risk?. JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, v. 65, n. 8, p. 709-714, AUG 2011. (04/12054-9)

DUTRA, ROBERTA LELIS; DE CARVALHO, MARCOS BRASILINO; DOS SANTOS, MARCELO; DA CUNHA MERCANTE, ANA MARIA; GAZITO, DIANA; DE CICCO, RAFAEL; TAJARA, ELOIZA HELENA; LOURO, IURI DRUMOND; ALVARES DA SILVA, ADRIANA MADEIRA; GRP, GENCAPO. FGFR4 Profile as a Prognostic Marker in Squamous Cell Carcinoma of the Mouth and Oropharynx. PLoS One, v. 7, n. 11, NOV 30 2012. (04/12054-9)

SILVEIRA, NELSON J. F.; VARUZZA, LEONARDO; MACHADO-LIMA, ARIANE; LAURETTO, MARCELO S.; PINHEIRO, DANIEL G.; RODRIGUES, RODRIGO V.; SEVERINO, PATRICIA; NOBREGA, FRANCISCO G.; SILVA, JR., WILSON A.; PEREIRA, CARLOS A. DE B.; et al. Searching for molecular markers in head and neck squamous cell carcinomas (HNSCC) by statistical and bioinformatic analysis of larynx-derived SAGE libraries. BMC MEDICAL GENOMICS, v. 1, NOV 11 2008. (04/12054-9)

MENDOZA LOPEZ, ROSSANA VERONICA; LEVI, JOSE EDUARDO; ELUF-NETO, JOSE; KOIFMAN, ROSALINA JORGE; KOIFMAN, SERGIO; CURADO, MARIA PAULA; MICHALUART-JUNIOR, PEDRO; ALVES FIGUEIREDO, DAVID LIVINGSTONE; SAGGIORO, FABIANO PINTO; DE CARVALHO, MARCOS BRASILINO; et al. Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection. CANCER CAUSES & CONTROL, v. 25, n. 4, p. 461-471, APR 2014. (10/50733-6, 04/12054-9)

MOYSES, RAQUEL AJUB; LOPEZ, ROSSANA VERONICA MENDOZA; CURY, PATRICIA MALUF; SIQUEIRA, SHEILA APARECIDA COELHO; CURIONI, OTAVIO ALBERTO; FILHO, JOSE FRANCISCO DE GOIS; FIGUEIREDO, DAVID LIVINGSTONE ALVES; TAJARA, ELOIZA HELENA; MICHALUART, PEDRO, JR.; HEAD NECK GENOME PROJECT GENCAPO. Significant differences in demographic, clinical, and pathological features in relation to smoking and alcohol consumption among 1,633 head and neck cancer patients. Clinics, v. 68, n. 6, p. 7-pg., 2013-01-01. (04/12054-9)

RODINI, CAMILA OLIVEIRA; AQUINO XAVIER, FLAVIA CALO; SILVA PAIVA, KATIUCIA BATISTA; DE SOUZA SETUBAL DESTRO, MARIA FERNANDA; MOYSES, RAQUEL AJUB; MICHALUARTE, PEDRO; CARVALHO, MARCOS BRASILINO; FUKUYAMA, ERICA ERINA; TAJARA, ELOIZA HELENA; OKAMOTO, OSWALDO KEITH; et al. Homeobox gene expression profile indicates HOXA5 as a candidate prognostic marker in oral squamous cell carcinoma. International Journal of Oncology, v. 40, n. 4, p. 1180-1188, APR 2012. (04/12054-9)

ANANTHARAMAN, DEVASENA; ABEDI-ARDEKANI, BEHNOUSH; BEACHLER, DANIEL C.; GHEIT, TARIK; OLSHAN, ANDREW F.; WISNIEWSKI, KATHY; WUNSCH-FILHO, VICTOR; TOPORCOV, TATIANA N.; TAJARA, ELOIZA H.; LEVI, JOSE EDUARDO; et al. Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer. International Journal of Cancer, v. 140, n. 9, p. 8-pg., 2017-05-01. (04/12054-9, 10/51168-0)

LIU, HONGLIANG; LI, GUOJUN; STURGIS, ERICH M.; SHETE, SANJAY; DAHLSTROM, KRISTINA R.; DU, MULONG; AMOS, CHRISTOPHER, I; CHRISTIANI, DAVID C.; LAZARUS, PHILIP; WEI, QINGYI. Genetic variants in CYP2B6 and HSD17B12 associated with risk of squamous cell carcinoma of the head and neck. International Journal of Cancer, v. 151, n. 4, p. 12-pg., 2022-05-07. (04/12054-9, 10/51168-0)

RODRIGUES, MARIA F. S. D.; RODINI, CAMILA DE OLIVEIRA; XAVIER, FLAVIA C. DE AQUINO; PAIVA, KATIUCIA B.; SEVERINO, PATRICIA; MOYSES, RAQUEL A.; LOPEZ, ROSSANA M.; DECICCO, RAFAEL; ROCHA, LILIA A.; CARVALHO, MARCOS B.; et al. PROX1 Gene is Differentially Expressed in Oral Cancer and Reduces Cellular Proliferation. MEDICINE, v. 93, n. 28, DEC 2014. (08/06223-3, 04/12054-9)

KHETAN, PRERNA; BOFFETTA, PAOLO; LUCE, DANIELE; STUCKER, ISABELLE; CURADO, MARIA PAULA; MENEZES, ANA; WUNSCH-FILHO, VICTOR; AHRENS, WOLFGANG; LAGIOU, PAGONA; SERRAINO, DIEGO; et al. Occupations and the Risk of Head and Neck Cancer A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, v. 61, n. 5, p. 397-404, MAY 2019. (10/51168-0, 04/12054-9)

GIRALDI, L.; LEONCINI, E.; PASTORINO, R.; WUNSCH-FILHO, V.; DE CARVALHO, M.; LOPEZ, R.; CADONI, G.; ARZANI, D.; PETRELLI, L.; MATSUO, K.; et al. Alcohol and cigarette consumption predict mortality in patients with head and neck cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Annals of Oncology, v. 28, n. 11, p. 2843-2851, NOV 2017. (10/51168-0, 04/12054-9)

DI CREDICO, GIOIA; EDEFONTI, VALERIA; POLESEL, JERRY; PAULI, FRANCESCO; TORELLI, NICOLA; SERRAINO, DIEGO; NEGRI, EVA; LUCE, DANIELE; STUCKER, ISABELLE; MATSUO, KEITARO; et al. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach. Oral Oncology, v. 94, p. 47-57, JUL 2019. (10/51168-0, 04/12054-9)

LEONCINI, EMANUELE; VUKOVIC, VLADIMIR; CADONI, GABRIELLA; GIRALDI, LUCA; PASTORINO, ROBERTA; ARZANI, DARIO; PETRELLI, LIVIA; WUNSCH-FILHO, VICTOR; TOPORCOV, TATIANA NATASHA; MOYSES, RAQUEL AYUB; et al. Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium. EUROPEAN JOURNAL OF EPIDEMIOLOGY, v. 33, n. 12, p. 1205-1218, DEC 2018. (10/51168-0, 04/12054-9)

MOYSES, RAQUEL AJUB; LOPEZ, ROSSANA VERONICA MENDOZA; CURY, PATRICIA MALUF; SIQUEIRA, SHEILA APARECIDA COELHO; CURIONI, OTAVIO ALBERTO; FILHO, JOSE FRANCISCO DE GOIS; FIGUEIREDO, DAVID LIVINGSTONE ALVES; TAJARA, ELOIZA HELENA; MICHALUART, JR., PEDRO; GENCAPO, HEAD NECK GENOME PROJECT. Significant differences in demographic, clinical, and pathological features in relation to smoking and alcohol consumption among 1,633 head and neck cancer patients. Clinics, v. 68, n. 6, p. 738-744, Jun. 2013. (04/12054-9)

TOPORCOV, TATIANA NATASHA; ZNAOR, ARIANA; ZHANG, ZUO-FENG; YU, GUO-PEI; WINN, DEBORAH M.; WEI, QINGYI; VILENSKY, MARTA; VAUGHAN, THOMAS; THOMSON, PETER; TALAMINI, RENATO; et al. Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium. International Journal of Epidemiology, v. 44, n. 1, p. 169-185, FEB 2015. (10/51168-0, 04/12054-9)

MENDES, SUZANNY OLIVEIRA; DOS SANTOS, MARCELO; PETERLE, GABRIELA TONINI; MAIA, LUCAS DE LIMA; STUR, ELAINE; AGOSTINI, LIDIANE PIGNATON; DE CARVALHO, MARCOS BRASILINO; TAJARA, ELOIZA HELENA; LOURO, IURI DRUMOND; TRIVILIN, LEONARDO OLIVEIRA; et al. HIF-1alpha Expression Profile in Intratumoral and Peritumoral Inflammatory Cells as a Prognostic Marker for Squamous Cell Carcinoma of the Oral Cavity. PLoS One, v. 9, n. 1, JAN 9 2014. (04/12054-9)

RODRIGUES-LISONI, FLAVIA C.; PEITL, JR., PAULO; VIDOTTO, ALESSANDRA; POLACHINI, GIOVANA M.; MANIGLIA, JOSE V.; CARMONA-RAPHE, JULIANA; CUNHA, BIANCA R.; HENRIQUE, TIAGO; SOUZA, CAIQUE F.; TEIXEIRA, RODRIGO A. P.; et al. Genomics and proteomics approaches to the study of cancer-stroma interactions. BMC MEDICAL GENOMICS, v. 3, MAY 4 2010. (04/12054-9)

DOS SANTOS, MARCELO; STUR, ELAINE; MAIA, LUCAS LIMA; AGOSTINI, LIDIANE PIGNATON; PETERLE, GABRIELA TONINI; MENDES, SUZANNY OLIVEIRA; TAJARA, ELOIZA HELENA; DE CARVALHO, MARCOS BRASILINO; LOURO, IURI DRUMOND; ALVARES SILVA-CONFORTI, ADRIANA MADEIRA. Genetic Variability of Inflammatory Genes in the Brazilian Population. GENETIC TESTING AND MOLECULAR BIOMARKERS, v. 17, n. 11, p. 844-848, NOV 1 2013. (04/12054-9)

DOS SANTOS, MARCELO; DA CUNHA MERCANTE, ANA MARIA; NUNES, FABIO DAUMAS; LEOPOLDINO, ANDREIA MACHADO; DE CARVALHO, MARCOS BRASILINO; GAZITO, DIANA; MENDOZA LOPEZ, ROSSANA VERONICA; OLGA CHIAPPINI, PAULA BLANDINA; DE CARVALHO NETO, PAULO BENTES; FUKUYAMA, ERICA ERINA; et al. Prognostic significance of NDRG1 expression in oral and oropharyngeal squamous cell carcinoma. MOLECULAR BIOLOGY REPORTS, v. 39, n. 12, p. 10157-10165, DEC 2012. (04/12054-9)

DOS SANTOS, MARCELO; DA CUNHA MERCANTE, ANA MARIA; LOURO, IURI DRUMOND; GONCALVES, ANTONIO JOSE; DE CARVALHO, MARCOS BRASILINO; TAJARA DA SILVA, ELOIZA HELENA; ALVARES DA SILVA, ADRIANA MADEIRA. HIF1-Alpha Expression Predicts Survival of Patients with Squamous Cell Carcinoma of the Oral Cavity. PLoS One, v. 7, n. 9, SEP 18 2012. (04/12054-9)

ALVES, V. A. F.; NONOGAKI, S.; CURY, P. M.; WUENSCH-FILHO, V.; DE CARVALHO, M. B.; MICHALUART-JUNIOR, P.; MOYSES, R. A.; CURIONI, O. A.; FIGUEIREDO, D. L. A.; SCAPULATEMPO-NETO, C.; et al. Annexin A1 subcellular expression in laryngeal squamous cell carcinoma. Histopathology, v. 53, n. 6, p. 715-727, DEC 2008. (02/01511-4, 02/07304-0, 02/01520-3, 04/12054-9)

DI CREDICO, GIOIA; POLESEL, JERRY; DAL MASO, LUIGINO; PAULI, FRANCESCO; TORELLI, NICOLA; LUCE, DANIELE; RADOI, LOREDANA; MATSUO, KEITARO; SERRAINO, DIEGO; BRENNAN, PAUL; et al. Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration. BRITISH JOURNAL OF CANCER, v. 123, n. 9, AUG 2020. (04/12054-9)

SOARES, PAMELA DE OLIVEIRA; CURY, PATRICIA MALUF; MENDOZA LOPEZ, ROSSANA VERONICA; CERNEA, CLAUDIO ROBERTO; FUKUYAMA, ERIKA ERINA; ALVES FIGUEIREDO, DAVID LIVINGSTONE; DA NOBREGA, FRANCISCO GORGONIO; CURIONI, OTAVIO ALBERTO; NUNES, FABIO DAUMAS; MOYSES, RAQUEL AJUB; et al. GTSP1 expression in non-smoker and nondrinker patients with squamous cell carcinoma of the head and neck. PLoS One, v. 12, n. 8, AUG 17 2017. (04/12054-9)

KACHURI, LINDA; SAARELA, OLLI; BOJESEN, STIG EGIL; SMITH, GEORGE DAVEY; LIU, GEOFFREY; LANDI, MARIA TERESA; CAPORASO, NEIL E.; CHRISTIANI, DAVID C.; JOHANSSON, MATTIAS; PANICO, SALVATORE; et al. Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers. International Journal of Epidemiology, v. 48, n. 3, p. 751-766, JUN 2019. (10/51168-0, 04/12054-9)

GOYAL, NEERAV; HENNESSY, MAX; LEHMAN, ERIK; LIN, WENXUE; AGUDO, ANTONIO; AHRENS, WOLFGANG; BOCCIA, STEFANIA; BRENNAN, PAUL; BRENNER, HERMANN; CADONI, GABRIELLA; et al. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium. ORAL DISEASES, v. N/A, p. 14-pg., 2022-04-08. (04/12054-9, 10/51168-0)

PERDOMO, SANDRA; ANANTHARAMAN, DEVASENA; FOLL, MATTHIEU; ABEDI-ARDEKANI, BEHNOUSH; DURAND, GEOFFROY; ROSA, LUCIANA ALBINA REIS; HOLMILA, REETTA; LE CALVEZ-KELM, FLORENCE; TAJARA, ELOIZA H.; WUNSCH-FILHO, VICTOR; et al. Genomic analysis of head and neck cancer cases from two high incidence regions. PLoS One, v. 13, n. 1, JAN 29 2018. (10/51168-0, 04/12054-9)

VIDOTTO, ALESSANDRA; POLACHINI, GIOVANA M.; DE PAULA-SILVA, MARINA; OLIANI, SONIA M.; HENRIQUE, TIAGO; LOPEZ, ROSSANA V. M.; CURY, PATRICIA M.; NUNES, FABIO D.; GOIS-FILHO, JOSE F.; DE CARVALHO, MARCOS B.; et al. Differentially expressed proteins in positive versus negative HNSCC lymph nodes. BMC MEDICAL GENOMICS, v. 11, AUG 29 2018. (04/12054-9)

LESSEUR, CORINA; DIERGAARDE, BRENDA; OLSHAN, ANDREW F.; WUNSCH-FILHO, VICTOR; NESS, ANDREW R.; LIU, GEOFFREY; LACKO, MARTIN; ELUF-NETO, JOSE; FRANCESCHI, SILVIA; LAGIOU, PAGONA; et al. Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer. Nature Genetics, v. 48, n. 12, p. 1544-1550, DEC 2016. (10/51168-0, 04/12054-9)

LESSEUR, CORINA; FERREIRO-IGLESIAS, AIDA; MCKAY, JAMES D.; BOSSE, YOHAN; JOHANSSON, MATTIAS; GABORIEAU, VALERIE; LANDI, MARIA TERESA; CHRISTIANI, DAVID C.; CAPORASO, NEIL C.; BOJESEN, STIG E.; et al. Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers. PLOS GENETICS, v. 17, n. 3, MAR 2021. (10/51168-0, 04/12054-9)

MAIA, LUCAS DE LIMA; PETERLE, GABRIELA TONINI; DOS SANTOS, MARCELO; TRIVILIN, LEONARDO OLIVEIRA; MENDES, SUZANNY OLIVEIRA; DE OLIVEIRA, MAYARA MOTA; DOS SANTOS, JOAQUIM GASPARINI; STUR, ELAINE; AGOSTINI, LIDIANE PIGNATON; MONTEIRO DA SILVA COUTO, CINTHIA VIDAL; et al. JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma. PLoS One, v. 13, n. 3, MAR 28 2018. (04/12054-9)

SHETE, SANJAY; LIU, HONGLIANG; WANG, JIAN; YU, ROBERT; STURGIS, ERICH M.; LI, GUOJUN; DAHLSTROM, KRISTINA R.; LIU, ZHENSHENG; AMOS, CHRISTOPHER I.; WEI, QINGYI. A Genome-Wide Association Study Identifies Two Novel Susceptible Regions for Squamous Cell Carcinoma of the Head and Neck. Cancer Research, v. 80, n. 12, p. 2451-2460, JUN 15 2020. (04/12054-9, 10/51168-0)

ARCHANJO, ANDERSON BARROS; EVANGELISTA MONTEIRO DE ASSIS, ARICIA LEONE; DE OLIVEIRA, MAYARA MOTA; MENDES, SUZANNY OLIVEIRA; BORCOI, ALINE RIBEIRO; MAIA, LUCAS DE LIMA; DE SOUZA, RAFAEL PEREIRA; DE CICCO, RAFAEL; SAITO, KELLY CRISTINA; KIMURA, EDNA TERUKO; et al. Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival. SCIENTIFIC REPORTS, v. 10, n. 1, JUN 25 2020. (04/12054-9, 10/51168-0)

BRAVI, FRANCESCA; LEE, YUAN-CHIN AMY; HASHIBE, MIA; BOFFETTA, PAOLO; CONWAY, DAVID I.; FERRARONI, MONICA; LA VECCHIA, CARLO; EDEFONTI, VALERIA; INVESTIGATORS, INHANCE CONSORTIUM. Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer. ORAL DISEASES, v. 27, n. 1, JUL 2020. (10/51168-0, 04/12054-9)