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Orexigenic, anorexigenic, pro and pre-inflamatory factors: effects of a multidisciplinary program for weight reduction in obese adolescents

Grant number: 06/00684-3
Support type:Regular Research Grants
Duration: October 01, 2006 - September 30, 2008
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Ana Raimunda Dâmaso
Grantee:Ana Raimunda Dâmaso
Home Institution: Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil

Abstract

In the last years, adipose tissue has been identified as an endocrine organ that release innumerous peptide and non-peptide factors. New researches have been developed with the aim to investigate the relationship between these molecular and hormonal mechanisms to central nervous system, to better clarify the regulation of food intake and energy expenditure. Other important factor is that some of these cytokines released by adipose tissue, the TNF-alpha and IL-6, are vasoatives peptides that may contribute to endothelial activation coming to a pro inflammatory state. In this way, the aim of the present study is to assess the profile and change in these orexigenic, anorexigenic, pro and anti inflammatory factors in answer to a multidisciplinary program (nutrition, physical activity, psychological and clinical monitoring) to reduce body mass in obese adolescents after 24 weeks of intervention. (AU)

Scientific publications (26)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CORGOSINHO, FLAVIA CAMPOS; ACKEL-D'ELIA, CAROLINA; TUFIK, SERGIO; DAMASO, ANA RAIMUNDA; DE PIANO, ALINE; SANCHES, PRISCILA DE LIMA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; SILVA, PATRICIA LEAO; CARNIER, JUNE; TOCK, LIAN; ANDERSEN, MONICA LEVY; MOREIRA, GUSTAVO ANTONIO; PRADELLA-HALLINAN, MARCIA; OYAMA, LILA MISSAE; DE MELLO, MARCO TULIO. Beneficial Effects of a Multifaceted 1-Year Lifestyle Intervention on Metabolic Abnormalities in Obese Adolescents With and Without Sleep-Disordered Breathing. METABOLIC SYNDROME AND RELATED DISORDERS, v. 13, n. 3, p. 110-118, APR 1 2015. Web of Science Citations: 5.
CAMPOS, RAQUEL M. S.; DE MELLO, MARCO T.; TOCK, LIAN; SILVA, PATRICIA L.; MASQUIO, DEBORAH C. L.; DE PIANO, ALINE; SANCHES, PRISCILA L.; CARNIER, JUNE; CORGOSINHO, FLAVIA C.; FOSCHINI, DENIS; TUFIK, SERGIO; DAMASO, ANA R. Aerobic Plus Resistance Training Improves Bone Metabolism and Inflammation in Adolescents who Are Obese. JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, v. 28, n. 3, p. 758-766, MAR 2014. Web of Science Citations: 20.
ACKEL-D'ELIA, C.; CARNIER, J.; BUENO, JR., C. R.; CAMPOS, R. M. S.; SANCHES, P. L.; CLEMENTE, A. P. G.; TUFIK, S.; DE MELLO, M. T.; DAMASO, A. R. Effects of Different Physical Exercises on Leptin Concentration in Obese Adolescents. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 35, n. 2, p. 164-171, FEB 2014. Web of Science Citations: 18.
DAMASO, ANA RAIMUNDA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; CARANTI, DANIELLE ARISA; DE PIANO, ALINE; FISBERG, MAURO; FOSCHINI, DENIS; SANCHES, PRISCILA DE LIMA; TOCK, LIAN; LEDERMAN, HENRIQUE MANOEL; TUFIK, SERGIO; DE MELLO, MARCO TULIO. Aerobic plus resistance training was more effective in improving the visceral adiposity, metabolic profile and inflammatory markers than aerobic training in obese adolescents. JOURNAL OF SPORTS SCIENCES, v. 32, n. 15, p. 1435-1445, 2014. Web of Science Citations: 31.
DAMASO, ANA RAIMUNDA; DE PIANO, ALINE; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; CORGOSINHO, FLAVIA CAMPOS; SIEGFRIED, WOLFGANG; CARANTI, DANIELLE ARISA; LANDI MASQUIO, DEBORAH CRISTINA; CARNIER, JUNE; SANCHES, PRISCILA DE LIMA; DA SILVA, PATRICIA LEAO; OLLER NASCIMENTO, CLAUDIA MARIA; OYAMA, LILA MISSAE; AGUILERA DANTAS, ALEXANDRE DAMASO; DE MELLO, MARCO TULIO; TUFIK, SERGIO; TOCK, LIAN. Multidisciplinary Approach to the Treatment of Obese Adolescents: Effects on Cardiovascular Risk Factors, Inflammatory Profile, and Neuroendocrine Regulation of Energy Balance. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2013. Web of Science Citations: 23.
DA SILVA, PATRICIA LEAO; DE MELLO, MARCO TULIO; CHEIK, NADIA CARLA; SANCHES, PRISCILA LIMA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; CARNIER, JUNE; INOUE, DANIELA; DO NASCIMENTO, CLAUDIA M. O.; OYAMA, LILA M.; TOCK, LIAN; TUFIK, SERGIO; DAMASO, ANA R. Reduction in the Leptin Concentration as a Predictor of Improvement in Lung Function in Obese Adolescents. Obesity Facts, v. 5, n. 6, p. 806-820, DEC 2012. Web of Science Citations: 13.
DE PIANO, ALINE; DE MELLO, MARCO T.; SANCHES, PRISCILA DE L.; DA SILVA, PATRICIA L.; CAMPOS, RAQUEL M. S.; CARNIER, JUNE; CORGOSINHO, FLAVIA; FOSCHINI, DENIS; MASQUIO, DEBORAH L.; TOCK, LIAN; OYAMA, LILA M.; DA PENHA OLLER DO NASCIMENTO, CLAUDIA MARIA; TUFIK, SERGIO; DAMASO, ANA R. Long-term effects of aerobic plus resistance training on the adipokines and neuropeptides in nonalcoholic fatty liver disease obese adolescents. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, v. 24, n. 11, p. 1313-1324, NOV 2012. Web of Science Citations: 40.
SANCHES, PRISCILA DE LIMA; DE MELLO, MARCO TULIO; HELFESTEIN FONSECA, FRANCISCO ANTONIO; ELIAS, NATALIA; DE PIANO, ALINE; CARNIER, JUNE; TOCK, LIAN; OYAMA, LILA MISSAE; TUFIK, SERGIO; DAMASO, ANA. Insulin Resistance Can Impair Reduction on Carotid Intima-Media Thickness in Obese Adolescents. Arquivos Brasileiros de Cardiologia, v. 99, n. 4, p. 892-897, OCT 2012. Web of Science Citations: 7.
ZIMBERG, IONA ZALCMAN; DAMASO, ANA; DEL RE, MARIANA; CARNEIRO, ALINE MILLANI; SOUZA, HELTON DE SA; DE LIRA, FABIO SANTOS; TUFIK, SERGIO; DE MELLO, MARCO TULIO. Short sleep duration and obesity: mechanisms and future perspectives. Cell Biochemistry and Function, v. 30, n. 6, p. 524-529, AUG 2012. Web of Science Citations: 33.
DA SILVA, PATRICIA LEAO; DE MELLO, MARCO TULIO; CHEIK, NADIA CARLA; SANCHES, PRISCILA LIMA; DE PIANO, ALINE; CORGOSINHO, FLAVIA CAMPOS; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; CARNIER, JUNE; INOUE, DANIELA; DO NASCIMENTO, CLAUDIA M. O.; OYAMA, LILA M.; TOCK, LIAN; TUFIK, SERGIO; DAMASO, ANA R. The Role of Pro-inflammatory and Anti-inflammatory Adipokines on Exercise-Induced Bronchospasm in Obese Adolescents Undergoing Treatment. Respiratory Care, v. 57, n. 4, p. 572-582, APR 2012. Web of Science Citations: 13.
CAMPOS, RAQUEL M. S.; LAZARETTI-CASTRO, MARISE; DE MELLO, MARCO TULIO; TOCK, LIAN; SILVA, PATRICIA L.; CORGOSINHO, FLAVIA C.; CARNIER, JUNE; DE PIANO, ALINE; SANCHES, PRISCILA L.; MASQUIO, DEBORAH C. L.; TUFIK, SERGIO; DAMASO, ANA R. Influence of visceral and subcutaneous fat in bone mineral density of obese adolescents. Arquivos Brasileiros de Endocrinologia e Metabologia, v. 56, n. 1, p. 12-18, FEB 2012. Web of Science Citations: 18.
CARNIER, JUNE; SANCHES, PRISCILA DE LIMA; DA SILVA, PATRICIA LEAO; DE PIANO, ALINE; TOCK, LIAN; CAMPOS, RAQUEL M. S.; CORGOSINHO, FLAVIA C.; CORREA, FABIOLA ALVISE; MASQUIO, DEBORAH; OLLER DO NASCIMENTO, CLAUDIA MARIA; OYAMA, LILA MISSAE; ERNANDES, REGINA H.; DE MELLO, MARCO TULIO; TUFIK, SERGIO; DAMASO, ANA R. Obese adolescents with eating disorders: Analysis of metabolic and inflammatory states. Physiology & Behavior, v. 105, n. 2, p. 175-180, JAN 18 2012. Web of Science Citations: 9.
DA SILVA, PATRICIA LEAO; DE MELLO, MARCO TULIO; CHEIK, NADIA CARLA; SANCHES, PRISCILA LIMA; CORREIA, FABIOLA ALVISE; DE PIANO, ALINE; CORGOSINHO, FLAVIA CAMPOS; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; DO NASCIMENTO, CLAUDIA M. O.; OYAMA, LILA M.; TOCK, LIAN; TUFIK, SERGIO; DAMASO, ANA R. Interdisciplinary therapy improves biomarkers profile and lung function in asthmatic obese adolescents. PEDIATRIC PULMONOLOGY, v. 47, n. 1, p. 8-17, JAN 2012. Web of Science Citations: 29.
PRADO, WAGNER L.; OYAMA, LILA M.; LOFRANO-PRADO, MARA C.; DE PIANO, ALINE; STELLA, SERGIO G.; NASCIMENTO, CLAUDIA M. O.; CARNIER, JUNE; CARANTI, DANIELLE A.; TOCK, LIAN; TUFIK, SERGIO; DE MELLO, MARCO TULIO; DAMASO, ANA R. Alterations in Downstream Mediators Involved in Central Control of Eating Behavior in Obese Adolescents Submitted to a Multidisciplinary Therapy. JOURNAL OF ADOLESCENT HEALTH, v. 49, n. 3, p. 300-305, SEP 2011. Web of Science Citations: 5.
DAMASO, ANA R.; DE PIANO, ALINE; SANCHES, PRISCILA L.; CORGOSINHO, FLAVIA; TOCK, LIAN; OYAMA, LILA M.; TOCK, LUCIANA; OLLER DO NASCIMENTO, CLAUDIA M.; TUFIK, SERGIO; DE MELLO, MARCO TULIO. Hyperleptinemia in obese adolescents deregulates neuropeptides during weight loss. Peptides, v. 32, n. 7, p. 1384-1391, JUL 2011. Web of Science Citations: 28.
DE MELLO, MARCO TULIO; DE PIANO, ALINE; CARNIER, JUNE; SANCHES, PRISCILA DE LIMA; CORREA, FABIOLA ALVISE; TOCK, LIAN; ERNANDES, REGINA M. Y.; TUFIK, SERGIO; DAMASO, ANA R. Long-Term Effects of Aerobic Plus Resistance Training on the Metabolic Syndrome and Adiponectinemia in Obese Adolescents. JOURNAL OF CLINICAL HYPERTENSION, v. 13, n. 5, p. 343-350, MAY 2011. Web of Science Citations: 35.
LIRA, FABIO SANTOS; ROSA, JOSE CESAR; DOS SANTOS, RONALDO VAGNER; VENANCIO, DANIEL PAULINO; CARNIER, JUNE; SANCHES, PRISCILA DE LIMA; OLLER DO NASCIMENTO, CLAUDIA MARIA; DE PIANO, ALINE; TOCK, LIAN; TUFIK, SERGIO; DE MELLO, MARCO TULIO; DAMASO, ANA R.; OYAMA, LILA MISSAE. Visceral fat decreased by long-term interdisciplinary lifestyle therapy correlated positively with interleukin-6 and tumor necrosis factor-alpha and negatively with adiponectin levels in obese adolescents. METABOLISM-CLINICAL AND EXPERIMENTAL, v. 60, n. 3, p. 359-365, MAR 2011. Web of Science Citations: 35.
SANCHES, PRISCILA DE LIMA; DE MELLO, MARCO TULIO; ELIAS, NATALIA; HELFENSTEIN FONSECA, FRANCISCO ANTONIO; DE PIANO, ALINE; CARNIER, JUNE; OYAMA, LILA MISSAE; TOCK, LIAN; TUFIK, SERGIO; DAMASO, ANA RAIMUNDA. Improvement in HOMA-IR is an independent predictor of reduced carotid intima-media thickness in obese adolescents participating in an interdisciplinary weight-loss program. HYPERTENSION RESEARCH, v. 34, n. 2, p. 232-238, FEB 2011. Web of Science Citations: 27.
OYAMA, LILA MISSAE; OLLER DO NASCIMENTO, CLAUDIA MARIA; CARNIER, JUNE; DE PIANO, ALINE; TOCK, LIAN; SANCHES, PRISCILA DE LIMA; CORREA GOMES, FABIOLA ALVISE; TUFIK, SERGIO; DE MELLO, MARCO TULIO; DAMASO, ANA R. The role of anorexigenic and orexigenic neuropeptides and peripheral signals on quartiles of weight loss in obese adolescents. Neuropeptides, v. 44, n. 6, p. 467-474, DEC 2010. Web of Science Citations: 22.
DE PIANO, ALINE; TOCK, LIAN; CARNIER, JUNE; FOSCHINI, DENIS; SANCHES, PRISCILA DE LIMA; CORREA, FABIOLA ALVISE; OYAMA, LILA MISSAE; OLLER DO NASCIMENTO, CLAUDIA MARIA; LEDERMAN, HENRIQUE MANOEL; ERNANDES, REGINA; DE MELLO, MARCO TULIO; TUFIK, SERGIO; DAMASO, ANA. The role of nutritional profile in the orexigenic neuropeptide secretion in nonalcoholic fatty liver disease obese adolescents. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, v. 22, n. 5, p. 557-563, MAY 2010. Web of Science Citations: 15.
DE PIANO, ALINE; TOCK, LIAN; CARNIER, JUNE; OYAMA, LILA M.; OLLER DO NASCIMENTO, CLAUDIA M.; MARTINZ, ANIELLA C.; FOSCHINI, DENIS; SANCHES, PRISCILA L.; ERNANDES, REGINA M. Y.; DE MELLO, MARCO TULIO; TUFIK, SERGIO; DAMASO, ANA R. Negative correlation between neuropeptide Y/agouti-related protein concentration and adiponectinemia in nonalcoholic fatty liver disease obese adolescents submitted to a long-term interdisciplinary therapy. METABOLISM-CLINICAL AND EXPERIMENTAL, v. 59, n. 5, p. 613-619, MAY 2010. Web of Science Citations: 16.
FOSCHINI, DENIS; ARAUJO, RONALDO C.; BACURAU, REURY F. P.; DE PIANO, ALINE; DE ALMEIDA, SANDRO S.; CARNIER, JUNE; ROSA, THIAGO D. S.; DE MELLO, MARCO T.; TUFIK, SERGIO; DAMASO, ANA R. Treatment of Obese Adolescents: The Influence of Periodization Models and ACE Genotype. OBESITY, v. 18, n. 4, p. 766-772, APR 2010. Web of Science Citations: 44.
DO PRADO, WAGNER LUIZ; DE PIANO, ALINE; LAZARETTI-CASTRO, MARISE; DE MELLO, MARCO TULLIO; STELLA, SERGIO GARCIA; TUFIK, SERGIO; OLLER DO NASCIMENTO, CLAUDIA MARIA; OYAMA, LILA MISSAE; LOFRANO, MARA CRISTINA; TOCK, LIAN; CARANTI, DANIELLE ARISA; DAMASO, ANA RAIMUNDA. Relationship between bone mineral density, leptin and insulin concentration in Brazilian obese adolescents. JOURNAL OF BONE AND MINERAL METABOLISM, v. 27, n. 5, p. 613-619, SEP 2009. Web of Science Citations: 33.
FOSCHINI, DENIS; DOS SANTOS, RONALDO V. T.; PRADO, WAGNER L.; DE PIANO, ALINE; LOFRANO, MARA C.; MARTINS, ANIELA C.; CARNIER, JUNE; CARANTI, DANIELLE A.; SANCHES, PRISCILA DE L.; TOCK, LIAN; DE MELLO, MARCO T.; TUFIK, SERGIO; DAMASO, ANA R. Platelet and leptin in obese adolescents. Jornal de Pediatria, v. 84, n. 6, p. 516-521, NOV-DEC 2008. Web of Science Citations: 11.
RICARDO EGUCHI; NADIA CARLA CHEIK; LILA MISSAE OYAMA; CLAUDIA MARIA OLLER DO NASCIMENTO; MARCO TÚLIO DE MELLO; SERGIO TUFIK; ANA DÂMASO. Efeitos do exercício crônico sobre a concentração circulante da leptina e grelina em ratos com obesidade induzida por dieta. Revista Brasileira de Medicina do Esporte, v. 14, n. 3, p. 182-187, Jun. 2008.
CARNIER‚ J.; LOFRANO‚ M.C.; PRADO‚ W.L.; CARANTI‚ D.A.; DE PIANO‚ A.; TOCK‚ L.; DO NASCIMENTO‚ C.M.O.; OYAMA‚ L.M.; MELLO‚ M.T.; TUFIK‚ S.; OTHERS. Hormonal alteration in obese adolescents with eating disorder: effects of multidisciplinary therapy. Hormone Research in Paediatrics, v. 70, n. 2, p. 79-84, 2008.

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