Dependence of the alcohol: study of possible reduction of compulsion for the association of naltrexone with polyunsatureted fatty acid (PUFAs)

• Grant number: 06/01641-6
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2006
• End date: July 31, 2008
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: José Carlos Fernandes Galduroz
• Grantee: José Carlos Fernandes Galduroz
• Host Institution: Departamento de Psicobiologia. Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The study naltrexone in alcohol dependents searchs to verify the influence of the association of acid the fatty polyunsaturateds (PUFAS. Naltrexone has shown to be an important substance in the reduction of the craving for the alcohol. The association of the PUFAS with naltrexone searchs to normalize offers of these acid ones that in alcoholics probably they are diminished by the deficiency in the absorption beyond the bad nutrition. These acid ones are the lipidics components of the cellular membranes. The modified permeability of the neuronals membranes is one of the theories of the effect of the alcohol on the central nervous system. (AU)