Immune cellular response and parasitological charge in the experimental infection in Balb/c mice inoculated with Leishmania chagasi and submitted at immunosuppression

• Grant number: 06/03517-0
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2006
• End date: September 30, 2008
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
• Principal Investigator: Helio Langoni
• Grantee: Helio Langoni
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Visceral Leishmaniasis is one zooanthroponosis caused by a flagellum protozoan of Leishmania Leishmania donovani genus complex, worldwide distributed and in Brazil the specie involved is Leishmania chagasi, the vector is Lutzomyia longipalpis and the main reservoir is the dog. The great concern of the health professionals are the imunesuppressive patients as in AIDS cases, organs transplant, neoplasias, corticosteroid therapy, among others factors. Those become susceptible to a lot of infections, mainly by protozoans. The knowledgement about the immunologic behavior in the situation is the extrem importance and thus we intended to study the correlated aspects of the parasitic load in spleen, liver and immunopatology, according to citocine production in murine model using infected BALB/c mice with Leishmania chagasi, after that immunessupressing them and contrasting it to the result between groups. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

JL HOFFMANN; JG MACHADO; FC GAIO; LA DIAS-MELICIO; H LANGONI. Experimental infection with Leishmania chagasi in immunosuppressed Balb/c mice: cytokines and parasite burdens. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 15, n. 3, p. 391-410, 2009-00-00. (06/03517-0)