| Grant number: | 10/00552-5 |
| Support Opportunities: | Regular Research Grants |
| Start date: | July 01, 2010 |
| End date: | December 31, 2011 |
| Field of knowledge: | Health Sciences - Medicine - Surgery |
| Principal Investigator: | Rogério Saad Hossne |
| Grantee: | Rogério Saad Hossne |
| Host Institution: | Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
| Associated researchers: | Adriana Beatriz Barretto |
Abstract
Endometriosis is a gynecological pathology where endometrial tissue is found outside the uterus. Estimates indicate that at least 25% of all women between 30 and 40 years old can present this disease. The clinical picture includes asymptomatic and symptomatic forms. The main signs and symptoms are: changes in menstrual cycle, recurrent chronic pelvic pain, and fertility disorders. Its prevalence can reach 60% when considering a more specific population of women with pelvic pain or infertility. The best treatment is surgery, firstly by removing the endometriosis foci, secondly because it has the highest resolution indices. Even so, recurrence indices are high reaching levels around 47%.Recent trials have studied new treatment options in the pharmacological area aimed at reducing the number of invasive procedures, impeding endometriotic invasion, improve evolution prognosis, and reducing recurrence indices.However, testing treatment with new medications requires the use of experimental models before clinical tests on humans. These tests are suitable for investigating the mechanisms responsible for peritoneal lesion development.They are also suitable for evaluating the effects of treatments such as the use of immunomodulator and anti-inflammatory drugs, the focus of this study. Choosing the intraperitoneal route for this study was interesting, because, as well as a reported lack of damage to peritoneal integrity, it may also reduce the occurrence of associated systemic side effects.Considering experimental data already obtained from earlier studies in our laboratory with aspirin, that it is widely used, and its pharmacological effects and risks are already well known, we believe it suitable for use in this proposal.The objective of this study is to evaluate the effects of acetylsalicylic acid (aspirin) solution in peritoneal implants on autologous endometrium in mature rabbits as a basis for a therapeutic method for treating endometriosis.Based on a project design sample size calculated with the statistician; on previous results; and with the aim of evaluating the acute and late effects of the solution on peritoneal endometriosis foci in rabbits, animals will be sacrificed after 24 hours and 10 days of treatment using four experimental groups: Group 1 - (10 animals) Treated with physiological solution (controls) and sacrificed after 24 hours treatment. Group 2 - (10 animals) Treated with aspirin solution and sacrificed after 24 hours treatment. Group 3 - (10 animals) Treated with physiological solution (controls) and sacrificed after 10 days treatment. Group 4 - (10 animals) Treated with aspirin solution and sacrificed after 10 days treatmentResults will be evaluated by studying size (width and length) and anatomopathology of lesions. (AU)
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