Research Grants 08/10937-1 - Pneumologia, Embolia pulmonar - BV FAPESP
Advanced search
Start date
Betweenand

Beneficial effects associated with matrix metalloproteinases inhibition as coadjuvant to inotropic therapy dring acute pulmonary embolism

Abstract

Acute pulmonary embolism is a critical condition that is associated with high mortality rates and high morbidity. This condition results from the migration of emboli to the lungs, thus obstructiong pulmonary blood flow and increasing pulmonary arterial pressure and pulmonary vascular resistance. Many ohter factors conctribute to the pulmonary hypertension. These factors include vasoactive factors and hypoxic pulmonary vasoconstriction. Death results from acute pulmonary embolism when right ventricule failure supevines, which is associated with right ventricular contractile dysfunction. Recent results have implicated matrix metalloproteinases in the pathophysiology of acute pulmonary embolism. These enzymes may be activated in the right ventricule and degrade contractile proteins. In this project, we will examine whether matrix metalloproteinases inhibition with doxycycline produces beneficial effects through protection of myocardial cells from protein degradation. Moreover, we will examine whether inotropic drugs produce improved effects on myocardial function when MMPs are inhibited during acute pulmonary embolism. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Please report errors in scientific publications list using this form.
X

Report errors in this page


Error details: